A5034290503- Ion Channels and Receptors
- Connexins and lens biology
- Immune cells in cancer
- Barrier Structure and Function Studies
- Ion channel regulation and function
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
Women and Children’s Health Research Institute
2023
University of Alberta
2023
Université de Montréal
2022-2023
Multiple sclerosis (MS) is an inflammatory disease characterized by myelin loss. While therapies exist to slow MS progression, no treatment currently exists for remyelination. Remyelination, linked reduced disability in MS, relies on microglia and monocyte-derived macrophages (MDMs). This study aims understand the role of during remyelination lineage tracing depleting them. Microglial reveals that both MDMs initially accumulate, but later dominate lesion. Microglia engulf equal amounts...
Abstract Pericytes are multifunctional cells of the vasculature that vital to brain homeostasis, yet many their fundamental physiological properties, such as Ca 2+ signaling pathways, remain unexplored. We performed pharmacological and ion substitution experiments investigate mechanisms underlying pericyte in acute cortical slices PDGFRβ-Cre::GCaMP6f mice. report mid-capillary signalling differs from ensheathing type pericytes it is largely independent L- T-type voltage-gated calcium...
Abstract Pericytes are multifunctional cells of the vasculature that vital to brain homeostasis, yet many their fundamental physiological properties remain unexplored. Ca 2+ is a ubiquitous second messenger across cell-types, where it mediates diverse functions such as contractility and gene transcription. It therefore important understand cellular mechanisms underlying signalling in capillary pericytes. Here, we performed pharmacological ion substitution experiments investigate pericyte...