A5015688649- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Vagus Nerve Stimulation Research
- Neurological disorders and treatments
- Pain Management and Treatment
- Neuroscience and Neural Engineering
- Advanced Drug Delivery Systems
- Wireless Body Area Networks
- Optical Coherence Tomography Applications
- Electromagnetic Fields and Biological Effects
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Nerve injury and regeneration
- Pediatric Pain Management Techniques
- Ultrasound and Cavitation Phenomena
- Advanced Fluorescence Microscopy Techniques
- Advanced MRI Techniques and Applications
- Laser Material Processing Techniques
- Thermoregulation and physiological responses
- Body Image and Dysmorphia Studies
- Diamond and Carbon-based Materials Research
Wasatch Molecular (United States)
2025
University of Utah
2021-2024
Abstract Objective : Transcranial focused low-intensity ultrasound has the potential to noninvasively modulate confined regions deep inside human brain, which could provide a new tool for causal interrogation of circuit function in humans. However, it been unclear whether approach is potent enough behavior. Approach To test this, we applied brain thalamic target, ventral intermediate nucleus, three patients with essential tremor. Main results Brief, 15 s stimulations target at 10% duty cycle...
Severe forms of depression have been linked to hyperactivity the subcallosal cingulate cortex. The ability stimulate cortex or associated circuits noninvasively and directly would maximize number patients who could receive treatment. To this end, we developed an ultrasound-based device for effective noninvasive modulation deep brain circuits. Here describe application tool individual with treatment-resistant depression.
Abstract Transcranial focused ultrasound provides noninvasive and reversible approaches for precise personalized manipulations of brain circuits, with the potential to transform our understanding function treatments dysfunction. However, effective applications in humans have been limited by human head, which attenuates distorts severely unpredictably. This has led uncertain intensities delivered into brain. Here, we address this lingering barrier using a direct measurement approach that can...
Direct interventions into deep brain circuits constitute promising treatment modalities for chronic pain. Cingulotomy and stimulation targeting the anterior cingulate cortex have shown notable improvements in unpleasantness of pain, but these require surgeries. In this study, we developed an approach that can modulate affective hub entirely noninvasively, using low-intensity transcranial-focused ultrasound. Twenty patients with pain received two 40-minute active or sham protocols were...
Low-intensity focused ultrasound provides the means to noninvasively stimulate or release drugs in specified deep brain targets. However, successful clinical translations require hardware that maximizes acoustic transmission through skull, enables flexible electronic steering, and accurate reproducible targeting while minimizing use of MRI. We have developed a device addresses these practical requirements. The delivers temporal parietal skull windows, which minimize attenuation distortions...
Low-intensity ultrasound can stimulate excitable cells in a noninvasive and targeted manner, but which parameters are effective has remained elusive. This question been difficult to answer because differences transducers parameters-frequency particular-lead profound the stimulated tissue volumes. The objective of this study is control for these evaluate stimulating cells.Here, we human peripheral nervous system using single transducer operating range frequencies, matched volumes with an...
Transcranial focused ultrasound enables precise and non-invasive manipulations of deep brain circuits in humans, promising to provide safe effective treatments various neurological mental health conditions. Ultrasound targets can be used modulate neural activity directly or localize the release psychoactive drugs. However, these applications have been impeded by a key barrier—the human skull, which attenuates strongly unpredictably. To address this issue, we developed an ultrasound-based...
Abstract Objective Low-intensity ultrasound can stimulate excitable cells in a noninvasive and targeted manner, but which parameters are effective has remained elusive. This question been difficult to answer because differences transducers parameters—frequency particular—lead profound the stimulated tissue volumes. The objective of this study is control for these evaluate stimulating cells. Methods Here, we human peripheral nervous system using single transducer operating range frequencies,...
Abstract Transcranial ultrasound is emerging as a noninvasive tool for targeted treatments of brain disorders. has been used remotely mediated surgeries, transient opening the blood-brain barrier, local drug delivery, and neuromodulation. However, all applications have limited by severe attenuation phase distortion skull. Here, we characterized dependence aberrations on specific anatomical segments In particular, measured propagation properties throughout perimeter intact human skulls at 500...
Systems that emit electromagnetic or sonic waves for diagnostic interventional applications often have constraints on the size of their aperture, and thus produce an elongated focus in axial dimension. This extended depth limits imaging resolution spatial specificity delivered energy. Here, we developed a method substantially minimizes focus. The superimposes beams distinct frequencies space time to create constructive interference at target amplify deconstructive everywhere else, sharpening...