A5103037730- Natural product bioactivities and synthesis
- RNA Research and Splicing
- Cardiomyopathy and Myosin Studies
- Malaria Research and Control
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Chromatography in Natural Products
- Cancer Treatment and Pharmacology
- Ginseng Biological Effects and Applications
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Plant chemical constituents analysis
- Cancer therapeutics and mechanisms
- Genomics, phytochemicals, and oxidative stress
- Nanoparticle-Based Drug Delivery
- Synthesis and biological activity
- Growth Hormone and Insulin-like Growth Factors
- Ziziphus Jujuba Studies and Applications
Ningxia Medical University
2025
Shanxi Medical University
2017-2019
Background Gastric cancer is the world’s leading tumor disease in terms of morbidity and mortality currently treated clinically with a comprehensive approach based on surgery. Studies have demonstrated antitumor effects neferine, but anti-cancer mechanism for gastric not yet clear. Methods The Pubchem Swiss TargetPrediction databases were searched to retrieve targets action neferine. Meanwhile, relevant gene expression data downloaded by means Gene Expression Omnibus(GEO) database screen...
Abstract It is urgent to develop new antimalarial drugs with good therapeutic effects address the emergence of drug resistance. Here, artelinic acid-choline derivative (AD) was synthesized by dehydration reaction and esterification reaction, aimed avoid resistance synergistic effect artemisinins choline derivative, which could compete for rate-limiting enzymes in phosphatidylcholine (PC) biosynthetic pathway. AD formulated into liposomes (ADLs) thin-film hydration method. Efficacy ADLs...
Docetaxel (DTX) solution has some serious adverse side effects. A redox-responsive DTX prodrug synthesized in our laboratory was used to prepare self-assembled nanoparticles (DSNPs) with the method of nanoprecipitation. This study aimed at optimizing formulation develop stable preparation for delivery DTX. Single-factor test evaluate effects concentration prodrug, stirring speed, types stabilizers and temperature on prescription process DSNPs. The particle size polydispersity index were...