A5029613883- Dutch Social and Cultural Studies
- Comparative and International Law Studies
- Criminal Law and Evidence
- Long-Term Effects of COVID-19
- Tryptophan and brain disorders
- COVID-19 Clinical Research Studies
- Stress Responses and Cortisol
- Lysosomal Storage Disorders Research
- Respiratory Support and Mechanisms
- SARS-CoV-2 detection and testing
- Intensive Care Unit Cognitive Disorders
- SARS-CoV-2 and COVID-19 Research
- Inhalation and Respiratory Drug Delivery
- Biosensors and Analytical Detection
- Glycosylation and Glycoproteins Research
- European and International Law Studies
- Glycogen Storage Diseases and Myoclonus
- Respiratory and Cough-Related Research
- Gastroesophageal reflux and treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Carbohydrate Chemistry and Synthesis
- Taxation and Legal Issues
- Corporate Governance and Law
- Legal Issues in South Africa
- Hormonal and reproductive studies
Université Libre de Bruxelles
2020-2025
Centre Hospitalier Universitaire de Saint-Pierre
2020-2025
Universitair Ziekenhuis Brussel
2021-2025
UCB Pharma (Belgium)
2021-2024
Erasmus MC
2009
Erasmus University Rotterdam
2009
Leiden University
1995-1999
Ziekenhuisnetwerk Antwerpen Stuivenberg
1999
Introduction: COVID-19 Ag Respi-Strip, an immunochromatographic (ICT) assay for the rapid detection of SARS-CoV-2 antigen on nasopharyngeal specimen, has been developed to identify positive patients allowing prompt clinical and quarantine decisions. In this original research article, we describe conception, analytical performances as well risk management implementing Respi-Strip in a diagnostic decision algorithm. Materials Methods: Development resulted ready-to-use ICT based membrane...
Abstract Lung function impairment persists in 55% of critical COVID-19 patients three months after ICU discharge. Patient lung function, exercise capacity, radiologic, and quality life data suggest is related to radiologic involvement at admission.
Abstract Objective To investigate the digestive enzymes and biomarkers in saliva of patients with laryngopharyngeal reflux (LPR) asymptomatic individuals. Study Design Prospective controlled study. Setting Multicenter Methods Patients LPR at hypopharyngeal‐esophageal impedance‐pH monitoring (HEMII‐pH) individuals were consecutively recruited from January 2020 to April 2023 2 University Hospitals. The (off PPIs) was collected measure pH, elastase, bile salts, cholesterol, gastric, pancreatic...
Direct-to-consumer testing (DTCT) refers to commercial laboratory tests initiated by laypersons without the involvement of healthcare professionals. As this market grows in size and variety products, a clear definition DTCT ground conceptualization their harms benefits is needed. We describe how three different modalities (home self-testing, self-sampled tests, direct access tests) present caveats traditional process ('brain-to-brain loop'), might differ between medical vs. non-medical...
Background Chemerin is an extracellular protein with chemotactic activities and its expression increased in various diseases such as metabolic syndrome inflammatory conditions. Its role lung pathology has not yet been extensively studied but both known pro- anti-inflammatory properties have observed. The aim of our study was to evaluate the involvement chemerin/ChemR23 system physiopathology COVID-19 a particular focus on prognostic value. Methods Blood samples from confirmed patients were...
Introduction: Since the first wave of COVID-19 in Europe, new diagnostic tools using antigen detection and rapid molecular techniques have been developed. Our objective was to elaborate a algorithm combining tests, automated dosing tests assess its performance under routine conditions. Methods: An analytical evaluation four one point-of-care test performed on samples sent our laboratory for SARS-CoV-2 reverse transcription PCR. We then established by approaching median viral loads target...
Abstract Objective To investigate the presence and clinical value of salivary elastase, pepsin, trypsin, cholesterol, bile salts in development laryngopharyngeal reflux disease‐related chronic cough (LPRD‐CC). Study Design Prospective controlled study. Setting University hospital Methods Patients with LPRD at 24‐hour hypopharyngeal‐esophageal multichannel intraluminal impedance‐pH monitoring were recruited from two European hospitals. Symptoms findings evaluated symptom score (RSS),...
Introduction: Despite improved management of patients with COVID-19, we still ignore whether pharmacologic treatments and respiratory support have modified outcomes for intensive care unit (ICU) surviving the three first consecutive waves (w) pandemic. The aim this study was to evaluate developments in ICU COVID-19 positively impacted functional outcomes, quality life (QoL), chest CT scan patterns at 3 months, according pandemic waves. Methods: We prospectively included all admitted two...
The recent isolation of the CLN3 gene involved in Batten disease (juvenile neuronal ceroid lipofuscinosis) creates possibilities for direct detection mutations which can confirm or indicate clinical diagnosis disease. We have designed a rapid and reliable allele specific PCR test major deletion, be used carrier diagnosis, presymptomatic prenatal diagnosis.
There is a trend towards decentralisation of laboratory tests by means Point-of-Care testing (POCT). Within hospitals, Belgian law requires POCT policy, coordinated the clinical laboratory. however no legal framework for performed outside hospital: reimbursement, compulsory quality monitoring and limits nor control on prices charged to patient. Uncontrolled use can have negative consequences individual public health.We propose that hospitals would only be reimbursed carried out within...
Abstract Haplotype analysis in a collaborative collection of 143 families with juvenile‐onset neuronal ceroid lipofuscinosis (JNCL) or Batten (Spielmeyer‐Vogt‐Sjögren) disease has permitted refined localization the gene, CLN3, which was assigned to chromosome 16 1989. Recombination events four maternal meioses delimit new flanking genetic markers for CLN3 localize gene interval 16p12.1‐11.2 between microsatellite D16S288 and D16S383. This narrows position region 2.1 cM, significant reduction...
In COVID-19 intensive care unit (ICU)-admitted patients, multi-organ acute complications lead to long-lasting sequelae. The aim of this study was assess 1) changes in chest CT, pulmonary function test (PFT), functional capacity (6-minute walking distance (6MWT)), and health-related quality life (HR-QoL) among ICU survivors at 3, 6, 12 months after discharge 2) predictors persistent impairment/ improvement 6MWT HR-QoL. were prospectively included. Outcomes included PFT, 6MWT, respiratory...