A5016815007- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
- Cancer, Stress, Anesthesia, and Immune Response
- Microtubule and mitosis dynamics
- Immune cells in cancer
- Cancer-related gene regulation
Ege University
2018-2021
Prostate cancer is one of the most common for men worldwide with advanced forms showing supernumerary or clustered centrosomes. Hematological and neurological expressed 1 (HN1) also known as Jupiter Microtubule Associated Homolog (JPT1) belongs to a small poorly understood family genes that are evolutionarily conserved across vertebrate species. The co-expression network HN1 from TCGA PRAD dataset indicates putative role in centrosome-related processes context prostate cancer. expression low...
The studies on the relationship between inflammation and cancer progression have been mostly carried out with monolayer cell cultures in vitro, which can be insufficient to mimic tumor tissue. Here, we established a three-dimensional (3D) culture model of inflammatory microenvironment for prostate cells better evaluate role carcinogenesis. Formation spheroids has achieved LNCaP, Du145, LNCaP-104r2 lines but not RWPE1 normal epithelial PC3 by using 3D Petri Dish®. We also showed that...