A5048741755- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Bacterial Identification and Susceptibility Testing
- Pharmaceutical Practices and Patient Outcomes
- Antimicrobial Resistance in Staphylococcus
- Immune Response and Inflammation
- Hemophilia Treatment and Research
- Platelet Disorders and Treatments
- Neutropenia and Cancer Infections
- Pharmaceutical studies and practices
- Pharmaceutical and Antibiotic Environmental Impacts
- Inhalation and Respiratory Drug Delivery
- Health Systems, Economic Evaluations, Quality of Life
- Antibiotic Use and Resistance
- Intensive Care Unit Cognitive Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Blood Coagulation and Thrombosis Mechanisms
- Analytical Methods in Pharmaceuticals
- Parkinson's Disease Mechanisms and Treatments
- Anesthesia and Sedative Agents
- Asthma and respiratory diseases
- Restless Legs Syndrome Research
- Nerve injury and regeneration
- Drug Transport and Resistance Mechanisms
Uppsala University
2016-2025
University of Florida
2017
Columbus Oncology and Hematology Associates
2017
Uppsala University Hospital
2006-2011
We investigated the effects of exendin-4 on neural stem/progenitor cells in subventricular zone adult rodent brain and its functional an animal model Parkinson's disease. Our results showed expression GLP-1 receptor mRNA or protein cultured isolated from this region. In vitro, increased number cells, expressing neuronal markers microtubule-associated 2, beta-III-tubulin, neuron-specific enolase. When was given intraperitoneally to naïve rodents together with bromodeoxyuridine, a marker for...
A pharmacokinetic-pharmacodynamic (PKPD) model that characterizes the full time course of in vitro time-kill curve experiments antibacterial drugs was here evaluated its capacity to predict previously determined PK/PD indices. Six (benzylpenicillin, cefuroxime, erythromycin, gentamicin, moxifloxacin, and vancomycin), representing a broad selection mechanisms action PK PD characteristics, were investigated. For each drug, dose fractionation study simulated, using wide range total daily doses...
Background The addition of oral entacapone to levodopa-carbidopa intestinal gel treatment leads less conversion levodopa 3-O-methyldopa, thereby increasing plasma concentration. objective this study was compare systemic exposure the newly developed levodopa-entacapone-carbidopa after a 20% dose reduction with usual in randomized crossover trial advanced Parkinson's disease patients. Methods In 48-hour study, 11 patients treated were sequence. Blood samples drawn at prespecified times, and...
Abstract Background The emergence of β-lactamase-producing bacteria limits the effectiveness β-lactam (BL) antibiotics, and combination with a β-lactamase inhibitor (BLI) aims to counteract this resistance. However, existing guidelines primarily focus on optimizing dosing BLs do not adequately address interaction between BLIs, leading uncertain pharmacokinetic/pharmacodynamic (PK/PD) targets potentially suboptimal strategies. Objectives To investigate optimal PK/PD strategies for avibactam...
Dosing of antibacterial agents is generally based on point estimates the effect, even though bacteria exposed to antibiotics show complex kinetic behaviors. The use whole time course observed effects would be more advantageous. aim present study was develop a semimechanistic pharmacokinetic (PK)/pharmacodynamic (PD) model characterizing events seen in bacterial system when it with different mechanisms action. Time-kill curve experiments were performed strain Streptococcus pyogenes wide range...
Gentamicin is commonly used in the management of neonatal infections. Development adaptive resistance typical for aminoglycosides and reduces antibacterial effect. There is, however, a lack understanding how this phenomenon influences effect different dosing schedules. The aim was to develop pharmacokinetic-pharmacodynamic (PKPD) model that describes time course bactericidal activity gentamicin its investigate schedules preterm term newborn infants based on developed model. In vitro...
Parkinson's disease is characterized by motor deficits caused loss of midbrain dopaminergic neurons. Neurotrophic factors and cell transplantation have partially restored function in models disease, but had limited effects humans. Here we show that intracerebroventricular administration platelet-derived growth factor-BB can offer an alternative strategy to restore disease; In animal nigrostriatal injury, a two weeks treatment with resulted long-lasting restoration striatal dopamine...
Aims This study aims to assess approaches handle interoccasion variability (IOV) in a model‐based therapeutic drug monitoring (TDM) context, using population pharmacokinetic model of coagulation factor VIII as example. Methods We assessed 5 TDM approaches: empirical Bayes estimates (EBEs) from including IOV, with individualized doses calculated based on individual parameters either (i) or (ii) excluding related IOV; and EBEs IOV by (iii) setting zero, (iv) summing variances interindividual...
Suboptimal use of medications is a leading cause health care-related harm. Medication reviews improve medication use, but evidence the possible benefit inpatient review for hard clinical outcomes after discharge scarce.To study effects hospital-based comprehensive (CMRs), including postdischarge follow-up older patients' care resources, compared with only and usual care.The Reviews Bridging Healthcare trial cluster randomized crossover that was conducted in 8 wards multiprofessional teams at...
Combination therapy can be a strategy to ensure effective bacterial killing when treating Pseudomonas aeruginosa, Gram-negative bacterium with high potential for developing resistance. The aim of this study was develop pharmacokinetic/pharmacodynamic (PK/PD) model that describes the in vitro time–kill curves colistin and meropenem alone combination one WT meropenem-resistant strain P. aeruginosa. In curve experiments were conducted aeruginosa (ATCC 27853) (MICs: 1 mg/L; mg/L) type (ARU552)...
In silico pharmacokinetic/pharmacodynamic (PK/PD) models can be developed based on data from in vitro time–kill experiments and provide valuable information to guide dosing of antibiotics. The aim was develop a mechanism-based model that describe Escherichia coli MG1655 WT six isogenic mutants exposed ciprofloxacin identify relationships may used simplify future characterizations similar setting. this study, we PK/PD describing killing kinetics for E. following exposure ciprofloxacin....
The purpose of this study was to develop a whole-body physiologically based pharmacokinetic (WB-PBPK) model for ciprofloxacin ICU patients, on only plasma concentration data. In next step, tissue and organ time profiles in patients were predicted using the developed model. WB-PBPK built non-linear mixed effects approach data from 102 adult intensive care unit patients. Tissue distribution coefficients (Kp) available literature used as informative priors. successfully characterized both...
ObjectivesThis study aimed to explore the interactions of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae.MethodsFive clinical isolates multidrug-resistant K. pneumoniae producing KPC-2, KPC-3, NDM-1, OXA-48 and VIM-1 carbapenemases were used. Polymyxin was tested alone amikacin, aztreonam, cefepime, chloramphenicol, ciprofloxacin, fosfomycin, linezolid, meropenem, minocycline, rifampicin, temocillin, thiamphenicol trimethoprim....