A5070812440- Renal cell carcinoma treatment
- Renal and related cancers
- Multiple and Secondary Primary Cancers
- Venous Thromboembolism Diagnosis and Management
- Bladder and Urothelial Cancer Treatments
- Cardiac tumors and thrombi
- Neuroblastoma Research and Treatments
- Medical Imaging and Pathology Studies
- Pediatric Urology and Nephrology Studies
- Prostate Cancer Treatment and Research
- Renal and Vascular Pathologies
- Vascular anomalies and interventions
- Prostate Cancer Diagnosis and Treatment
- Rocket and propulsion systems research
- Sarcoma Diagnosis and Treatment
- Combustion and Detonation Processes
- Testicular diseases and treatments
- Energetic Materials and Combustion
- Medical and Biological Sciences
- Neuroendocrine Tumor Research Advances
- Cancer Diagnosis and Treatment
- Genetic and Kidney Cyst Diseases
- Engineering Technology and Methodologies
- Hepatocellular Carcinoma Treatment and Prognosis
- Skin Protection and Aging
Ministry of Health of the Russian Federation
2019-2025
Ministry of Health
2024
Pirogov Russian National Research Medical University
2024
National Technical University "Kharkiv Polytechnic Institute"
2019
Hadassah Medical Center
2009-2018
Cancer Research Center
2014
Background. Patients with germ cell tumors (GCTs) and poor-prognosis demonstrate unsatisfactory oncological outcomes, a one-year progression-free survival (PFS) rate of approximately 50%. We hypothesized that switching the chemotherapy regimen to TIP (paclitaxel, ifosfamide (mesna), cisplatin) in cases unfavorable decline serum tumor markers (STMs) after first cycle BEP (bleomycin, etoposide, could improve treatment outcomes this subgroup patients. Materials Methods. A multicenter,...
Objective. To evaluate short-term and long-term results of nephrectomy, thrombectomy, circular inferior vena cava (IVC) resection in patients with renal cell carcinoma (RCC) advanced IVC tumor invasion. Materials methods . Medical data 49 RCC level II–IV venous thrombus wall invasion were analyzed. All the underwent (radical – 35 (71.0 %), cytoreductive, M+ cases 14 (28.6 %)). Circular infrarenal segment was performed 25 (51.0 %) patients; infrarenal, perirenal retrohepatic segments a...
Objective: to develop an effective and safe surgical technique for the treatment of patients with renal cell carcinoma invasive tumor venous thrombosis inferior vena cava (IVC). Materials methods. The study included 75 underwent at N.N. Blokhin Russian Cancer Research Center between 1995 2017. median age was 57 years (range: 32–72 years). All were diagnosed RCC levels II–IV; them, 55 (73.3 %) had complete IVC obstruction mature collaterals. Twenty- seven (26.0 regional, 37 (49.3 – distant...
Objective: to identify the predictors of perioperative complications and deaths in surgically treated patients with kidney cancer complicated by venous tumor thrombosis. Subjects methods. The investigation included data on 463 venous patients, median age was 57 years. male / female ratio 2.5:1. Perirenal, subhepatic, retrohepatic, supradiaphragmatic thrombi were diagnosed in 161 (34.8 %), 135 (29.2 82 (17.7 85 (18.3 %) patients, respectively. Regional distant metastases occurred 90 (19.4...
Objective: to identify independent risk factors affecting survival of patients with renal cell carcinoma (RCC) and tumor venous thrombosis who have undergone nephrectomy thrombectomy. Materials methods. This study included 768 RCC complicated by Median age was 58 years (range: 16-82 years); the male female ratio 2.3:1. The symptoms were identified in 232 (30.2 %); laboratory abnormalities at baseline observed 456 (59.3 %). Grade I II diagnosed %) 201 (26.2 patients, respectively; grade III...
Cancer of the renal pelvis, in particular squamous cell form, is an extremely rare neoplasm this localization. Chronic inflammation thought to be a risk factor for disease due presence stones collecting system. Having no specific clinical manifestations, tumor often incidental finding identified during examination patients other reasons. This article presents case carcinoma pelvis patient with long course urolithiasis and staghorn stones, complicated by kidney abscess diagnosed CT MRI.
Kidney cancer is the 3rd most common disease in oncological urology. In 4–10 % cases, tumor thrombus of inferior vena cava diagnosed. literature, single-digit number cases organ-preserving surgical treatment patients with kidney complicated by described. The article presents a rare clinical case synchronous bilateral morphologically different left renal vein, perirenal segment cava, pyeloureteral stone right ureter.
Aim. To perform comparative analysis of functional outcomes repeat kidney resection and radical nephrectomy in patients with local cancer recurrence after previous organ-sparing surgeries. Materials methods. Data on 64 who underwent surgical treatment at the Oncourology Department N.N. Blokhin National Medical Research Center Oncology between 2000 2022 due to nephron-sparing surgeries were retrospectively prospectively included study. Among these, 37 (57.8 %) (treatment group) 27 (42.2...
Purpose of the study: analysis our experience in performing robotic-assisted nephron-sparing surgeries using da robotic system. Material and Methods. The retrospective study included first 37 consecutive patients who underwent robot-assisted partial nephrectomy from May 2020 to december 2022. Results. To assess surgical outcomes undergoing nephrectomy, three parameters associated with trifecta achievement were analyzed. was assessed according standard criteria, whereas quadfecta, which...
Background. Combination therapy is the standard of care for intermediate and poor prognosis metastatic renal cell carcinoma. In IMDC prognostic classification, tumor stage histological type are not considered due to lack independent impact on overall survival. The CLEAR study demonstrated efficacy lenvatinib pembrolizumab combination in long-term treatment outcomes, including survival compared sunitinib. KEYNOTE-B61 high this patients with non-clear Aim. To evaluate burden histotypes....
The movement of a bubble in an air stream with the consideration heat exchange process between air, shell and heated inside was numerically investigated. Numerical modeling carried out Ansys Fluent software product. It assumed that injection takes place flow, which has speed 3 m/s, temperature is 293 K. calculation for diameters bubbles, were equal to mm 5 mm. thickness 1 μm. at time into initial filled bubble, exceeds surrounding first variant by 10 K second 30 velocity field flow occurs...
The article presents the results of an experimental study screening properties a bubble obscurant in infrared range radiation. Detection masking effect bubbles was carried out by qualitative and quantitative measurements. A Hikmicro LYNX HM-TS03-25XG/W-LH25 thermal imager used to qualitatively assess bubbles. Fluke TIR27 professional for appearance observation field leads change signature object. In area visual intersection two bubbles, more intense approach contrast background observed than...
Objective : to analyze the impact of surgical volume on functional results and cardiospecific survival rates in patients with clinically localized renal carcinoma. Subjects methods . Four hundred fifty-three pT1–3aN0M0 renal cell carcinoma normally functioning second kidney who had undergone radical nephrectomy (n = 226 (49.9 %)) or resection 227 (50.1 were selected for investigation. The patient groups different-volume operations matched gender, age, body mass index (BMI), side...
Objective : to evaluate the outcomes of thrombectomy performed using different surgical techniques in renal cell carcinoma (RCC) patients with extensive tumor venous thrombosis. Materials and methods . This study included 345 RCC thrombosis who underwent treatment. The median age was 57 years (range: 16—79 years); male-to-female ratio 1:1.9. Two hundred sixty (75.4 %) had their thrombus originating from right vein, 85 (24.6 — left vein. In 169 (49.0 %), spread retrohepatic inferior vena cava...
Objective: to assess advisability of nephrectomy, inferior vena cava (IVC) thrombectomy in renal cell carcinoma (RCC) with tumor venous thrombosis and pulmonary metastases. Materials methods. We analyzed medical data 112 consecutive RCC patients metastases undergone IVC at N.N. Blokhin Cancer Center from 1971 2014. Median age was 57 (19–77) years, a male-to-female ratio – 4.1:1. Tumor occurred all achieved levels III–IV 36 (32.1 %) cases. Ten (8.9 had solitary, 102 (91.1 multiple lung...
Objective : to assess safety of left renal vein (LRV) ligation during circular resection the inferior vena cava in right-side kidney carcinoma with tumor venous thrombosis. Materials and methods . We selected medical data 63 cell patients invasion undergone nephrectomy, thrombectomy, IVC LRV (Group 1; n = 29 (46.0 %)) or preservation outflow from contralateral 2; 34 (54.0 %)). Median age study participants was 56.0 + 8.8 years (range: 32—72 years); a male female ratio 1:1.9. Such parameters...
The laser decontamination method is based on the evaporation of oxide films under influence radiation. With mechanism, radiation should heat upper layer film to boiling point during pulse and evaporate it. It relevant because growing environmental requirements in world, which makes it possible create a compact, energy-efficient installation. Unlike existing units, detonation system will significantly affect quickly decontaminate radioactive surfaces due Detonation technologies are critical...
В настоящее время стандартным подходом к ведению больных диссеминированным раком почки является таргетная терапия. Паллиативная нефрэктомия по-прежнему остается общепринятым методом, применяющимся в лечении данной категории больных. Результаты двух рандомизированных исследований свидетельствуют об увеличении общей выживаемости оперированных пациентов, получавших лечение цитокинами, по сравнению с больными, которым назначалась только иммунотерапия. ретроспективных сериях получены данные о...