A5022887083- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Virology and Viral Diseases
- COVID-19 diagnosis using AI
- COVID-19 epidemiological studies
- Earthquake Detection and Analysis
- Helicobacter pylori-related gastroenterology studies
- Bacteriophages and microbial interactions
- Bacillus and Francisella bacterial research
- Genomics and Phylogenetic Studies
- Hepatitis B Virus Studies
- SARS-CoV-2 detection and testing
- Phytoplasmas and Hemiptera pathogens
- Biochemical and Structural Characterization
- Viral Infections and Outbreaks Research
- Vibrio bacteria research studies
Ladoke Akintola University of Technology
2022-2023
This article is devoted to applying bioinformatics and immunoinformatics approaches for the development of a multi-epitope mRNA vaccine against spike glycoproteins circulating SARS-CoV-2 variants in selected African countries. The study’s relevance dictated by fact that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began its global threat at end 2019 since then has had devastating impact on whole world. Measures reduce threats from pandemic include social restrictions,...
At this present stage of COVID-19 re-emergence, designing an effective candidate vaccine for different variants SARS-CoV-2 is a study worthy consideration. This research used bioinformatics tools to design mRNA that captures all the circulating and lineages virus in its construct. Sequences these viruses were retrieved across six continents analyzed using screen preferable CD8+ T lymphocytes (CTL), CD4+ (HTL), B-cell epitopes. These epitopes vaccine. In addition, several other...
Introduction Infectious bursal disease (IBD), caused by the infectious Q8 virus (IBDV), is a highly contagious in young chickens, leading to immunosuppression with great economic importance. IBDV, non-enveloped bipartite dsRNA genome, infects bursa of Fabricius, causing severe gastrointestinal disease. Effective vaccines are urgently needed due limitations current oral vaccines, including degradation and low immunogenicity. This study designs evaluates multiepitope subunit vaccine using...
The discovery of a new SARS-CoV-2 virus strain in South Africa presents major public health threat, therefore contributing to increased infections and transmission rates during the second wave global pandemic. This study lays groundwork for development novel subunit vaccine candidate from circulating strains African provides an understanding molecular epidemiological trend strains. A total 475 whole-genome nucleotide sequences submitted between December 1, 2020 February 15, 2021 available at...
Messenger RNA (mRNA) vaccines emerged as a powerful tool in the fight against infections. Unlike traditional vaccines, this unique type of vaccine elicits robust and persistent innate humoral immune response with host cell-mediated pathogen gene expression antigen presentation.
Marburg virus is a highly virulent pathogen that causes hemorrhagic fever in humans and other primates, with no approved vaccines or treatments currently available. In this study, we designed potential mRNA vaccine candidate for using bioinformatics molecular modeling approach. We identified antigenic proteins VP24 glycoprotein predicted HTL, B cell, CTL epitopes these proteins. then selected proven antigenicity, non-allergenicity, non-toxicity linked them together to form construct...
Abstract The Mokola Virus belongs to the family Rhabdoviridae and is genotype 3 of Lyssavirus genera. A small number cases animal human encephalomyelitis, mainly scattered over sub-Saharan Africa, have been linked (MOKV). Currently there no vaccine protect against MOKV infection in people or animals. It has proven that rabies vaccination does not confer immunity infection, even though virus are related. Using immunoinformatics approaches, this study designed an mRNA can all five...
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Loiasis is caused by Loa loa, a vector-borne filarial parasitic worm endemic to Central and West Africa. It significant public health issue due its geographic overlap with Onchocerciasis Lymphatic Filariasis. has been reported that improper diagnosis of can complicate the treatment Filariasis, causing severe neurological reactions. Due this, there’s need for more sensitive method detect loa in humans.Hence, study aimed predict design novel, synthetic multi-epitope protein diagnosingLoiasis...
Abstract The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) has spread globally. Understanding transmission dynamics of SARS-CoV-2 contamination in environment is essential for infection control policies. This study aims to provide a phylodynamic analysis and distribution pattern from terms Source, clades, lineages, their location. Ninety (90) retrieved whole-genome sequences environmental sources GISAID were investigated determine...