A5026849591- Tendon Structure and Treatment
- 3D Printing in Biomedical Research
- Collagen: Extraction and Characterization
- Bone Tissue Engineering Materials
- Polymer Surface Interaction Studies
- Knee injuries and reconstruction techniques
- Graphene and Nanomaterials Applications
- Orthopedic Surgery and Rehabilitation
- Electrospun Nanofibers in Biomedical Applications
- Additive Manufacturing and 3D Printing Technologies
- Tissue Engineering and Regenerative Medicine
- Respiratory Support and Mechanisms
- Corrosion Behavior and Inhibition
- Cardiac Arrest and Resuscitation
- Click Chemistry and Applications
- Biocrusts and Microbial Ecology
- Silk-based biomaterials and applications
- Shoulder Injury and Treatment
- Engineering Technology and Methodologies
- Hydrogels: synthesis, properties, applications
- Orthodontics and Dentofacial Orthopedics
- Mechanical Circulatory Support Devices
Eindhoven University of Technology
2020-2022
Brigham and Women's Hospital
2013-2017
Harvard University
2013-2017
Universidad San Francisco de Quito
2016-2017
Universidad Internacional del Ecuador
2017
Innovation Research Center
2016
Harvard–MIT Division of Health Sciences and Technology
2013-2016
Massachusetts Institute of Technology
2013-2016
Harvard University Press
2013
Purdue University West Lafayette
2010-2012
We report the development of a nanoclay-rich bioactive hydrogel for bone regeneration therapy applications.
Collagen-based biomaterials are a viable option for tendon reconstruction and repair. However, the weak mechanical strength of collagen constructs is major limitation. We have previously reported novel methodology to form highly oriented electrochemically aligned (ELAC) threads with properties converging on those natural tendon. In this study, we assessed in vivo response rabbit patellar (PT) braided ELAC bioscaffolds. Rabbit PTs were incised longitudinally bioscaffold was inlaid one limb...
Abstract There are approximately 33 million injuries involving musculoskeletal tissues (including tendons and ligaments) every year in the United States. In certain cases ligaments damaged irreversibly require replacements that possess natural functional properties of these tissues. As a biomaterial, collagen has been key ingredient tissue engineering scaffolds. The application range would be greatly broadened if assembly process could better controlled to facilitate synthesis dense,...
A key step during the synthesis of collagen constructs is incubation monomeric in phosphate buffer saline (PBS) to promote fibrillogenesis network. Optimal PBS-treatment conditions for solutions induce gelation are well established literature. Recently, a report literature (Cheng et al 2008 Biomaterials 29 3278–88) showed novel method fabricate highly oriented electrochemically aligned (ELAC) threads which have orders magnitude greater packing density than gels. The optimal induction...
Approximately 1% of active individuals participating in sports rupture their anterior cruciate ligaments (ACL) every year, which is currently reconstructed using tendon autografts. Upon reconstruction, clinical issues concern are ACL graft rupture, persistent knee instability, limited return to sports, and early onset osteoarthritis (OA). This happens because autografts do not have the same compositional, structural, mechanical properties as a native ACL. To overcome these problems, we...
Approximately 90% of patients who suffer out-ofhospital cardiac arrest die [1]. Thus, when a cardiopulmonary resuscitation (CPR) maneuver is needed, rescuer fatigue problem because more than 2 minutes continuous CPR translates in defective delivery the technique [2]. This has two main components: first, lack access to trained professionals with adequate emergency medical equipment, and second, long delay receive immediate care [3]. After 7.8-magnitude earthquake Ecuador on April 2016, first...
Abstract Surface topography guides cell behavior and is a tool to endow biomaterials with bioactive properties. The large number of possible designs makes it challenging find the optimal surface structure induce specific response. TopoChip platform currently largest collection topographies 2176 in silico designed micro-topographies. Still, exploring only small part design space due boundary conditions algorithm engineering strategy. Inspired by diversity natural surfaces, we assessed what...
Our laboratory developed an electrochemical method which transforms collagen solutions to solid state material by densification and unidirectional alignment of molecules [1] based on the principles isoelectric focusing (IEF). Randomly oriented at onset migrate isoelectic plane when current is applied solution. However, driving forces behind phenomena are not fully understood.