Innovations in chronic disease management are growing rapidly as advancements technology broaden the scope of tools. Older adults less likely to be willing or able use patient portals smartphone apps for health-related tasks. The authors conducted a cross-sectional survey older (ages ≥50) with hypertension diabetes examine relationships between portal usage, interest health-tracking tools, and eHealth literacy, solicit practical solutions encourage adoption. Among 247 patients surveyed large...

Diabetic nephropathy (DN) is a complication of diabetes that increasing in prevalence China. Extracellular vesicles (EVs) carrying microRNAs (miRs) may represent useful tool the development therapies for DN. Here, we report EVs released by adipose-derived mesenchymal stem cells (ADSCs) during DN contain microRNA, miR-26a-5p, suppresses Using bioinformatic analyses, identified differentially expressed miRs from ADSCs and predicted downstream regulatory target genes. We isolated (MSCs) adipose...

Abstract Objective We assessed changes in the percentage of providers with positive perceptions electronic health record (EHR) benefit before and after transition from a local basic to commercial comprehensive EHR. Methods Changes EHR were captured via survey academic care (baseline) at 6–12 months (short term) 12–24 (long transition. analyzed 32 items for overall group by practice setting, provider age, specialty using separate multivariable-adjusted random effects logistic regression...

Organizational strategies for implementing eHealth tools influence patient and provider use of portal technology. This study examines whether the intensity bidirectional secure messaging is associated with improved clinical outcomes.This a retrospective cohort analysis 101 019 patients diabetes or hypertension (11 138 active users) who received primary care within Ochsner Health System between 2012 2014. Propensity score-adjusted multivariable fixed effects regression panel was used to...

Testicular torsion is an acute scrotal disorder requiring immediate emergency treatment. Ischemic injury and reperfusion are important causes of oxidative stress irreversible damage after testicular torsion. Although a large number literatures have discussed the treatment torsion, there currently lack systematic exploration historical evolution construction knowledge framework.The Web Science Core Collection was searched for studies on published between 2000 2022. The basic data literature...

Tuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis (Mtb) that affects millions of people worldwide. The majority individuals who are exposed to Mtb develop latent infections, in which immunological response antigens present but there no clinical evidence disease. Because currently available tests cannot differentiate at low risk from those highly susceptible developing active disease, considerable interest identification diagnostic biomarkers can...

Aims: Long non-coding RNA IRAIN (lncRNA IRAIN) plays a critical role in numerous malignancies. However, the function of lncRNA renal carcinoma (RC) remains enigmatic. The purpose this study is to characterize effects on RC progression. Methods: expression pattern and vascular endothelial growth factor A (VEGFA) tissues cells was characterized by RT-qPCR Western blot analysis. roles VEGFA progression were studied gain- or loss-of-function experiments. Bioinformatics data analysis used predict...

Objective We aimed to determine if fibroids in pregnancy, categorized by size, are associated with adverse obstetrical outcomes. Study Design Demographic, clinical, and delivery data were collected from charts of women singleton gestations who delivered at >20 weeks gestation identified routine anatomy scan their randomly selected age-matched controls. Largest fibroid diameter was used categorize small (≤5 cm) large (>5 cm). Results included 450 patients: 264 patients (174 small, 90...

Collaborative care models incorporating pharmacists have been shown to improve quality of for patients with hypertension and/or diabetes. Little is known about how integrate such services outside clinical trials. The authors implemented a 22-month observational study evaluate pharmacy collaborative and diabetes in safety net medical home that incorporated population risk stratification, decision support, medication dose adjustment protocols. Patients the group saw their primary provider...

ABSTRACT Background Clear cell renal carcinoma (ccRCC), the predominate histological type of (RCC), has been extensively studied, with poor prognosis as stage increases. Research findings consistently indicated that PI3K‐Akt pathway is commonly dysregulated across various cancer types, including ccRCC. Targeting held promise a potential therapeutic approach for treating Development and validation pathway‐related genes related biomarkers can enhance healthcare management patients Purpose This...

International guidelines advocate regular surveillance of patients following urothelial carcinoma (UC). A validated molecular diagnostic non-invasive urine test, Cxbladder Monitor, correctly identifies with a UC history who have low-probability recurrence. The present study assesses the clinical utility Monitor in reducing number and frequency urologic procedures ordered without missing detection recurrent UC.Data from 828 physician-patient assessments were generated 18 participant...

Autoimmune encephalitis (AE) is a newly recognized autoimmune disorders in which the targets are proteins or receptors involved synaptic transmission and neuronal excitability. α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) subtype of glutamate that mediates most fast excitatory neurotransmission brain. A 50-year-old woman presented with subacute onset memory loss behavioral changes. High levels serum (1:1000) CSF (1:32) antibodies against AMPAR GluR2 were detected....

The non-invasive Cxbladder urine test system has demonstrated clinical utility in ruling out urothelial carcinoma (UC) patients with asymptomatic microscopic hematuria (AMH), suggesting that the number of invasive diagnostic tests, including cystoscopy, used this patient population may be reduced by testing prior to conducting a full urological work-up. aim study was demonstrate enhanced communicating objective information on decisions made individual physicians AMH. Three hundred ninety-six...

The purpose of this study was to determine the incidences and rates progression varying degrees carotid stenosis that do not require intervention according Asymptomatic Carotid Atherosclerosis Study, European Surgery Trial, North American Symptomatic Endarterectomy from information, provide evidence-based recommendations for follow-up imaging.A retrospective review performed all ultrasound examinations at a single institution January 1995 through April 2015. Examinations following...

331 Background: Statins have been shown to possess antiproliferative activity in-vitro. Synergism with multiple drug combinations has of great interest in pancreatic cancer. We examined 2 in-vitro cell models for synergism using a combination fluvastatin and nab-paclitaxel. Methods: Pancreatic cancer lines Mia-Paca-2 (MP2) Su86 were cultivated seeded 25,000 cells/mL subsequently grown 96 well plates 24 hours. The cells then treated fixed concentration 9 rows, 8 receiving serial 1:2 dilutions...

This study aimed to explore the interaction and crosstalk between pathways in response destrin mutations.All from MINT database were downloaded, a protein-protein network was then constructed, investigated, particular, overlap of 2 significant pathway analysis results.As expected, results showed that regulation actin cytoskeleton mutations mice.Further indicated 28 crosstalked with regulating cytoskeleton.Importantly, 3 pathways, including pathway, cancer, B cell receptor signaling linked by...

INTRODUCTION: Obese women have an increased risk for failed induction of labor. We compare the effectiveness vaginal versus oral administration misoprostol induction. METHODS: A retrospective chart review was performed undergoing labor from November 2012 to June 2015. Included were viable, singleton pregnancies at 34 weeks gestation or beyond whose initial agent cervical ripening either 25 mcg administered vaginally 50 orally. Obesity defined as body mass index greater than equal 30. Primary...