A5023294594- Tannin, Tannase and Anticancer Activities
- Vitamin K Research Studies
- Circular RNAs in diseases
- Lipoproteins and Cardiovascular Health
- Multiple Myeloma Research and Treatments
- Peptidase Inhibition and Analysis
- Drug-Induced Hepatotoxicity and Protection
- Phytochemicals and Antioxidant Activities
- Biofuel production and bioconversion
- Bone health and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Vitamin D Research Studies
- Gut microbiota and health
- Uterine Myomas and Treatments
- MicroRNA in disease regulation
- Pharmacological Effects of Natural Compounds
- Phytochemical compounds biological activities
- Gout, Hyperuricemia, Uric Acid
- Oral Health Pathology and Treatment
- Oral microbiology and periodontitis research
- Curcumin's Biomedical Applications
- Phytochemical Studies and Bioactivities
- Case Reports on Hematomas
- Digestive system and related health
- Pharmacological Effects and Toxicity Studies
Medical University of Varna
2021-2024
University Hospital St. Marina
2024
One mechanism to regulate pathological vascular calcification (VC) is its active inhibition. Loss or inactivation of endogenic inhibitors a major inductor VC. Such are proteins rich in gamma-glutamyl residues (Gla-proteins), whose function strongly depends on vitamin K. The current narrative review focused discussing the role extrahepatic K-dependent Gla-proteins (osteocalcin, OC; matrix Gla-protein, MGP; Gla-rich protein, GRP) cardio-vascular pathology. possess several functionally forms...
Circular RNAs (circRNAs) are a group of special endogenous long non-coding which highly stable in the circulation, and, thus, more suitable as new biomarkers colorectal cancer (CRC). The aim our study was to explore plasma expression levels four circRNAs: has_circ_0001445, hsa_circ_0003028, hsa_circ_0007915 and hsa_circ_0008717 patients with CRC evaluate their associations clinicopathological characteristics clinical outcome patients. CircRNAs were extracted from patients’ obtained prior...
Abstract The present cross‐sectional clinical study aimed to examine the connection between statin exposure, coronary artery calcification (CAC), and vitamin K‐dependent proteins (VKDPs) in patients with cardiovascular (CV) conditions. Two groups of were studied: established CV disease (CVD) healthy at moderate risk for CVD (a control group). also split into users non‐users. following VKDPs measured plasma: uncarboxylated Matrix Gla‐protein (ucMGP), undercarboxylated (ucOC), carboxylated...
Dickkopf-1 (DKK-1) and sclerostin are essential Wnt/β-catenin pathway inhibitors, playing an important role in multiple myeloma bone disease (MBD). We aimed to examine the serum DKK-1 variations newly diagnosed (NDMM) patients at diagnosis course of therapy, including autologous stem cell transplantation (ASCT). This study included 41 NDMM-patients 33 controls. MBD was assessed by whole-body low-dose computed tomography. were assayed commercial ELISA kits. At diagnosis, revealed...
Abstract Paracetamol (PCM)-induced toxicity is a well-established pharmacological model. Cotinus coggygria medicinal plant rich in polyphenols, including the flavonoid fustin. The aim of present study was to evaluate effects fustin isolated from heartwood model PCM-induced liver damage. Male Wistar rats (n=48) were allocated four groups: Control, PCM, F5+PCM, F10+PCM. rodents treated daily orally for nine consecutive days as follows: groups F5+PCM and F10+PCM – with (suspended vehicle) at...
Abstract Trinitrobenzene sulfonic acid (TNBS)-induced colitis is a widely used animal model that mimics the signs and symptoms of inflammatory bowel disease. Fustin flavonoid found in Cotinus coggygria . The aim present study was to investigate effect fustin isolated from heartwood rat TNBS-induced colitis. In this experiment, 30 male Wistar rats were used, allocated three groups: Control, TNBS TNBS+F10. Colitis induced by rectal application TNBS. After induction colitis, at dose 10 mg/kg...
Abstract Gastric ulcer is a common health issue. Cotinus coggygria heartwood extracts rich in the flavonoids fustin and sulfuretin have shown protective effects rat model of indomethacin-induced gastric ulceration. Fustin itself has been ethanol-induced ulcer. In present study we aimed to reveal effect flavonoid isolated from was purified. The experiment performed on 30 male Wistar rats allocated three groups – Control, Indo F10. F10 group pretreated with (10 mg/kg b.w. for 7 days). Rats...
Background The disturbed pleiotropic functions of vitamin D are related to numerous chronic non-skeletal diseases. role insufficiency/deficiency in cardiovascular diseases (CVD) is controversial. Therefore, the aim was study status CVD patients and reveal possible relationships with risk factors. Methods This prospective includes 93 individuals devided into two groups - (n = 49) at for 44) served as controls. CVD-patients were stratified AF-group paroxysmal or persistent atrial fibrillation...
Abstract Objectives Plaque-induced gingivitis is one of the most widely distributed periodontal disorder during childhood. The control pathogenic potential plaque associated with oral hygiene status at individual, group, and population levels. We hypothesize that regular application complex hygiene-prophylaxis could beneficially modulate salivary amino acids profile in children different stage plaque-induced gingivitis. Therefore, we aimed to study acids’ relation certain clinical indicators...
The hallmark of multiple myeloma is related bone disease. Interactions between plasma cells (MPCs), stromal cells, and the marrow (BM) microenvironment play a critical role in pathogenesis MBD. Bone remodeling severely dysregulated with prevalence osteoclast activity. We aimed to assess circulating levels sRANKL, periostin, osteopontin as activators NDMM patients at diagnosis course treatment, correlations clinical laboratory data, evaluate their potential additional biomarkers for...
Cotinus coggygria Scop. is a medicinal plant, rich in tannins and flavonoids.The main flavonoid C. heartwood fustin.Studies have shown that extracts fustin exert anti-inflammatory action [1-2].Carrageenan-induced paw edema rats widely used model of acute inflammation.The aim the present study was to compare percent inhibition carrageenan-induced by 1/500 ethanol infusion from (EICCH) at doses 10 mg/kg 20 mg/kg.Two experiments were performed.In first experiment 16 male Wistar allocated two...
Abstract Objectives Matrix Gla protein (MGP) is a calcification inhibitor that plays role in preventing soft tissue and local mineralization of the vascular wall. The present study aimed to assess expression MGP Peripheral Blood Mononuclear Cells (PBMC) adult patients with CVD pathologies its association presence severity coronary artery calcium score (CACS) conventional risk factors. Methods was measured 87 individuals using real time qPCR. Subgrouping performed according etiologic...
Purpose: To assess the role of asymptomatic hyperuricemia for presence and severity coronary arterial calcium (CAC) in adults with different cardiovascular (CV) pathology its association conventional CV risk factors. Material/Methods: Adults (n=81) both genders were divided into controls: moderate- to high without known CVD; AF-group: CVD-patients paroxysmal or persistent atrial fibrillation sinus rhythm, HF–group: heart failure subjects preserved ejection fraction. A structured interview...