A5043694592- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Reproductive tract infections research
- Pelvic floor disorders treatments
- Cell Adhesion Molecules Research
- Preterm Birth and Chorioamnionitis
- Microbial Metabolism and Applications
- Probiotics and Fermented Foods
- Antimicrobial Peptides and Activities
- Reproductive System and Pregnancy
- Urinary Tract Infections Management
- Biochemical and Structural Characterization
Virginia Commonwealth University
2008-2019
Abstract The incidence of preterm birth exceeds 10% worldwide. There are significant disparities in the frequency among populations within countries, and women African ancestry disproportionately bear burden risk United States. In present study, we report a community resource that includes ‘omics’ data from approximately 12,000 samples as part integrative Human Microbiome Project. Longitudinal analyses 16S ribosomal RNA, metagenomic, metatranscriptomic cytokine profiles 45 90 term controls...
Polysaccharide intercellular adhesin (PIA), also known as poly-N-acetyl-β-(1-6)-glucosamine (PIA/PNAG) is an important component of Staphylococcus aureus biofilms and contributes to resistance phagocytosis. The proteins IcaA, IcaD, IcaB, IcaC are encoded within the (ica) operon synthesize PIA/PNAG. We discovered a mechanism phase variation in PIA/PNAG expression that appears involve slipped-strand mispairing. process reversible RecA-independent, involves expansion contraction simple...
ABSTRACT The staphylococcal accessory regulator SarA and the alternative sigma factor σ B have been previously identified as positive regulators, IcaR a negative regulator, of icaADBC expression. Here, we show that in Staphylococcus aureus are also required for icaR expression does not significant effect on its own