A5068879641- Advanced Condensed Matter Physics
- Physics of Superconductivity and Magnetism
- Magnetic and transport properties of perovskites and related materials
- Liver Disease Diagnosis and Treatment
- Nuclear materials and radiation effects
- Cellular transport and secretion
- Rare-earth and actinide compounds
- High-pressure geophysics and materials
- Cholesterol and Lipid Metabolism
- Magnetic properties of thin films
- Hepatitis C virus research
- Catalysis and Oxidation Reactions
- Cancer, Lipids, and Metabolism
- Multiferroics and related materials
- Glycosylation and Glycoproteins Research
- Liver Disease and Transplantation
- Metabolism, Diabetes, and Cancer
- Signaling Pathways in Disease
- Diet, Metabolism, and Disease
- Tea Polyphenols and Effects
- Pancreatic function and diabetes
- Birth, Development, and Health
- Transition Metal Oxide Nanomaterials
- Phytochemicals and Antioxidant Activities
- Medical Imaging Techniques and Applications
Hokkaido University
2025
Doshisha University
2008-2024
Toranomon Hospital
2020-2024
St. Marianna University School of Medicine
2014-2023
Kobe University
1993-2023
Aichi Science & Technology Foundation
2022
RIKEN
2011-2020
Research Organization of Information and Systems
2020
Kyushu University
2008-2019
Mitsubishi Electric (Japan)
2018
The low-density lipoprotein receptor-related protein (Lrp)-5 functions as a Wnt coreceptor. Here we show that mice with targeted disruption of Lrp5 develop low bone mass phenotype. In vivo and in vitro analyses indicate this phenotype becomes evident postnatally, demonstrate it is secondary to decreased osteoblast proliferation function Cbfa1-independent manner. expressed osteoblasts required for optimal signaling osteoblasts. addition, Lrp5-deficient display persistent embryonic eye...
Magnetic susceptibility, Cu NQR, and high-filed magnetization have been measured in polycrystalline $\mathrm{SrCu}{}_{2}(\mathrm{BO}{}_{3}{)}_{2}$ having a two-dimensional (2D) orthogonal network of dimers. This cuprate provides new class 2D spin-gap system $(\ensuremath{\Delta}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}30\mathrm{K})$ which the ground state can be solved ``exactly.'' Furthermore, magnetization, two plateaus corresponding to $\frac{1}{4}$ $\frac{1}{8}$ full moment...
We study the possibility of superconductivity in a trilayer Ruddlesden-Popper nickelate ${\mathrm{La}}_{4}{\mathrm{Ni}}_{3}{\mathrm{O}}_{10}$ under pressure both theoretically and experimentally, making comparison with recently discovered high ${T}_{c}$ superconductor ${\mathrm{La}}_{3}{\mathrm{Ni}}_{2}{\mathrm{O}}_{7}$, bilayer nickelate. Through DFT calculations, we find that structural phase transition from monoclinic to tetragonal takes place around 10--15 GPa. Using crystal structure,...
Glycosylphosphatidylinositol (GPI) anchoring of proteins is a posttranslational modification occurring in the endoplasmic reticulum (ER). After GPI attachment, are transported by coat protein complex II (COPII)-coated vesicles from ER. Because GPI-anchored (GPI-APs) localized lumen, they cannot interact with cytosolic COPII components directly. Receptors that link GPI-APs to thought be involved efficient packaging into vesicles; however, mechanisms GPI-AP sorting not well understood. Here we...
The MIRAGE guidelines are being developed in response to a critical need the glycobiology community clarify glycoanalytic results so that they more readily evaluated (in terms of their scope and depth) facilitate reproduction important laboratory. molecular biological complexity glycosylation process makes thorough reporting glycomics experiment highly challenging endeavor. resulting data specify identity quantity complex structures, precise features which sometimes inferred using prior...
Insulin and hepatocyte growth factor (HGF) induced morphologically different membrane rufflings in KB cells. Insulin-induced ruffling was inhibited by microinjection of rho GDI, an inhibitory GDP/GTP exchange regulator for both p21 rac small GTP-binding proteins, but not botulinum exoenzyme C3, known to selectively ADP-ribosylate impair its function. This GDI action prevented comicroinjection with guanosine 5'-(3-O-thio)triphosphate (GTP gamma S)-bound rac1 p21. In contrast, HGF-induced or...
Deposition of amyloid β (Aβ) in the brain is closely associated with Alzheimer disease (AD). Aβ generated from precursor protein (APP) by actions β- and γ-secretases. In addition to deposition parenchyma, cerebral vessel walls, termed angiopathy, observed more than 80% AD individuals. The mechanism for how accumulates blood vessels remains largely unknown. present study, we show that endothelial cells expressed APP770, a differently spliced APP mRNA isoform neuronal APP695, produced Aβ40...
Scope Glucagon‐like peptide‐1 (GLP‐1) is a type of incretin secreted from enteroendocrine L‐cells. Our previous studies demonstrated that curcumin (a yellow pigment turmeric) significantly increases the secretion GLP‐1 in L cell line (GLUTag cells). However, it not clear whether its action vivo directly enhances secretion, which then leads to reduction blood glucose levels via stimulation insulin secretion. In addition, molecular target curcumin‐induced has been clarified. Methods and...
Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from enteroendocrine L-cells. Although several nutrients induce GLP-1 secretion, there little evidence to suggest that non-nutritive compounds directly increase secretion. Here, we hypothesized anthocyanins secretion and thereby significantly contribute the prevention treatment of diabetes. Delphinidin 3-rutinoside (D3R) was shown in GLUTag L cells. The results suggested three hydroxyl or two methoxyl moieties on aromatic ring...
Rabphilin-3A is a downstream target molecule of Rab3A small GTP-binding protein and implicated in Ca2+-dependent neurotransmitter release. Here we have isolated rabphilin-3A-interacting from human brain cDNA library by the yeast two-hybrid method identified it to be α-actinin, known cross-link actin filaments into bundle. α-Actinin interacts with N-terminal region rabphilin-3A, which GTP-Rab3A interacts, this interaction stimulates activity α-actinin The rabphilin-3A inhibited guanosine...
Co nuclear-quadrupole-resonance (NQR) studies were performed in the recently discovered superconductor Na x CoO 2 · y H O to investigate physical properties superconducting (SC) and normal states. Two samples from same examined, a SC bilayer-hydrate sample with T c ∼4.7 K non-SC monolayer-hydrate sample. From measurement of nuclear-spin lattice relaxation rate 1/ 1 sample, it was found that coherence peak is absent just below proportional temperature far . These results, which are...
We previously studied fatty acid metabolism in the liver of nonalcoholic disease (NAFLD) and reported activation LXRalpha-SREBP-1c pathway hepatocytes. LXRalpha regulates cholesterol as well metabolism, its agonistic ligands are oxysterols. Moreover, there is some evidence that excess intake involved onset NAFLD. Therefore, this study, we examined expression metabolism-associated genes NAFLD by real-time PCR. Expression ACAT1 was up-regulated more noticeable non-obese rather than obese...
Administration of black-tea polyphenols (BTP) simultaneously reduced lymphatic recovery both (3)H-cholesterol and (14)C-trioleoylglycerol in rats that were cannulated the thoracic duct. BTP decreased vitro micellar solubility cholesterol a dose-dependent manner. When purified theaflavins, which are components BTP, used, theaflavin-monogallates (TFMGs), theaflavin-3-gallate (TF3G), theaflavin-3'-gallate (TF3'G) effective eliminating from bile salt micelles vitro. Theaflavin (TF)...
Administration of black-tea polyphenols (BTP) at 100 and 200 mg/kg body weight in rats suppressed postprandial hypertriacylglycerolemia a dose-dependent manner. BTP also lymphatic recovery (14)C-trioleoylglycerol that were cannulated the thoracic duct. dose-dependently inhibited activity pancreatic lipase vitro with an IC50 0.254 mg/mL. When purified theaflavins, which are components BTP, used, theaflavins galloyl moieties, but not those without moiety, lipase. Theaflavin-3,3'-digallate...
Abstract Glucagon‐like peptide‐1 ( GLP ‐1) is an incretin that secreted from enteroendocrine L‐cells. Dietary factor‐stimulation of endogenous ‐1 a promising strategy for increasing the action ‐1. Recent studies have shown berries rich in anthocyanins improve insulin sensitivity and reduce risk type 2 diabetes. Our previous study found anthocyanin delphinidin 3‐rutinoside (D3R) significantly increases secretion GLUT ag cells (enteroendocrine L cell line). Blackcurrants are contain high...
Predictive models for bacterial growth developed on the basis of experimental data obtained from culture media often yield different results observations in actual foods. Although this discrepancy may be due to differences compositional characteristics, food structure, and other factors, impacts behaviour have not yet been quantified modelled mathematically. This study first aimed quantify effects amino group concentrations kinetics Escherichia coli. A predictive model incorporating effect...
rho GDI is an inhibitory GDP/GTP exchange protein for the family. Recently, has been reported to interact with GTP-bound form of G25K and rac1 p21 inhibit their basal GTPase-activating (GAP)-stimulated GTPase activity. Here, we examined whether interacts rac inhibits GAP-stimulated activity, interacted both GDP- forms rhoA as estimated by measuring its ability a complex membrane-binding activity forms. The efficiency interaction was, however, about 10% that GDP-bound form. Moreover,...
Rabphilin-3A is a putative target protein for Rab3A, member of the small G superfamily that implicated in regulated secretion, particularly neurotransmitter release. contains at least two functionally different domains: N-terminal Rab3A-binding domain and C-terminal C2 domain, which interacts with both Ca2+ phospholipid. Because preferentially GTP-Rab3A rather than GDP-Rab3A, we have examined here whether affects GTPase activity Rab3A. its fragment, but not very weakly stimulated basal...
Aim: Recent studies have shown that lipid metabolic pathways are required for the entry, replication and secretion of hepatitis C virus (HCV). Although little is known about life cycle HCV in humans, activation cholesterol fatty acid biosynthesis may be critical proliferation. Methods: We assessed transcription levels genes essential liver samples obtained from patients with chronic determined their correlations. The serum low‐density lipoprotein (LDL) core antigen were also measured....
Many animal studies on improvement of lipid metabolism, using dietary components, fast the animals final day feeding. Although fasting has a significant impact its time-dependent influence is not fully understood. We examined effects several times metabolism. Rats fed with semisynthetic diet for 2 wk were killed after 0 (9:00 am), 6 (7:00 am-1:00 pm), 9 (0:00 am-9:00 and 13 h (8:00 pm-9:00 am) fasting. Compared to group, marked reduction liver weight hepatic triacylglycerol content was...
We study the possibility of superconductivity in a trilayer Ruddlesden-Popper nickelate La$_4$Ni$_3$O$_{10}$ under pressure both theoretically and experimentally, making comparison with recently discovered high $T_c$ superconductor La$_3$Ni$_2$O$_7$, bilayer nickelate. Through DFT calculations, we find that structural phase transition from monoclinic to tetragonal takes place around 20 GPa. Using crystal structure, investigate superconductivity, where combination fluctuation exchange...
The superconducting transition temperatures, $T_{\mathrm{c}}$, of La$_{4}$Ni$_{3}$O$_{10+\delta}$($\delta$ = 0.04 and -0.01) were determined under various pressures up to 124.9 GPa by electrical resistance measurements with a diamond anvil cell. $T_{\mathrm{c}}$ exhibits strong dependence on oxygen content within the pressure range approximately 20 80 GPa. At 48.0 GPa, La$_{4}$Ni$_{3}$O$_{10.04}$ peaks at 36 K, marking highest reported thus far.