Jessica Lee
A5101472258- Genetic diversity and population structure
- Wildlife Ecology and Conservation
- Genomics and Phylogenetic Studies
- Identification and Quantification in Food
- Genomic variations and chromosomal abnormalities
- RNA Research and Splicing
- Wildlife Conservation and Criminology Analyses
- RNA and protein synthesis mechanisms
- Genomics and Rare Diseases
- CRISPR and Genetic Engineering
- Chromosomal and Genetic Variations
- Genomics and Chromatin Dynamics
The rich diversity of morphology and behavior displayed across primate species provides an informative context in which to study the impact genomic on fundamental biological processes. Analysis that insight into long-standing questions evolutionary conservation biology is urgent given severe threats these are facing. Here, we present high-coverage whole-genome data from 233 representing 86% genera all 16 families. This dataset was used, together with fossil calibration, create a nuclear DNA...
Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding their clinical relevance remains largely incomplete. To systematically decipher the effects human variants, we obtained whole-genome data for 809 individuals from 233 primate species and identified 4.3 million common protein-altering variants with orthologs in humans. We show that these can be inferred to have nondeleterious humans based on presence at high allele...
Abstract Noncoding DNA is central to our understanding of human gene regulation and complex diseases 1,2 , measuring the evolutionary sequence constraint can establish functional relevance putative regulatory elements in genome 3–9 . Identifying genomic that have become constrained specifically primates has been hampered by faster evolution noncoding compared protein-coding 10 relatively short timescales separating primate species 11 previously limited availability whole-genome sequences 12...
ABSTRACT Accurate identification of evolutionarily significant units rare and threatened organisms provides a foundation for effective management conservation. Up to seven subspecies the critically endangered Yellow‐crested Cockatoo ( Cacatua sulphurea ) have been described, four which were commonly recognised pre‐2014. In absence genotypic data, C. delimitation has based on morphology, behaviour biogeography. To clarify genetic relationships shed light diversification this parrot radiation,...
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