A5084137976- Ocular Surface and Contact Lens
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Surfactants and Colloidal Systems
- Corneal Surgery and Treatments
- Advancements in Transdermal Drug Delivery
- Polymer Foaming and Composites
- Nanoparticle-Based Drug Delivery
- Retinal Diseases and Treatments
- Analytical chemistry methods development
- Polymer crystallization and properties
- Innovative Microfluidic and Catalytic Techniques Innovation
- Polymer Nanocomposites and Properties
- Analytical Chemistry and Chromatography
- Electrochemical Analysis and Applications
- Proteoglycans and glycosaminoglycans research
- Retinoids in leukemia and cellular processes
- Mental Health and Patient Involvement
- Retinal and Optic Conditions
- Ocular Disorders and Treatments
- Nasolacrimal Duct Obstruction Treatments
- Injection Molding Process and Properties
- Seed Germination and Physiology
- Additive Manufacturing and 3D Printing Technologies
- Retinal Development and Disorders
Waterford Institute of Technology
2016-2025
South East Technological University
2022-2025
The current treatment for the acquired retinal vasculopathies involves lifelong repeated intravitreal injections of either anti-vascular endothelial growth factor (VEGF) therapy or modulation inflammation with steroids. Consequently, any modification that decreases this burden patients and doctors alike would be a welcome intervention. To end, research aims to develop topically applied nanoparticulate system encapsulating corticosteroid extended drug release. Poly (lactic-co-glycolic acid)...
Dry eye disease (DED) or keratoconjunctivitis sicca is a chronic multifactorial disorder of the ocular surface caused by tear film dysfunction. Symptoms include dryness, irritation, discomfort and visual disturbance, standard treatment includes use lubricants topical steroids. Secondary inflammation plays prominent role in development propagation this debilitating condition. To address we have investigated pilot scale an innovative drug delivery system using dexamethasone-encapsulated...
Illustration of the preparation a twin nanoparticulate system.
Aims/Purpose: This study aims to improve bidirectional communication strategies between patients/public, preclinical researchers, and clinical experts address the lack of effective public patient involvement (PPI) in vision research, aiming refocus research on actual needs. Methods: An international team conducted multiple PPI activities, including a critical review ocular 1 , World‐café workshops, interviews, structured surveys, round‐table discussions. Dry Eye Disease's wide presentation...
Age-related macular degeneration and diabetic retinopathy are the main diseases that cause vision impairment. The standard treatment for this condition is intravitreal injection of anti-vascular endothelial growth factor agents, which several side effects to eye after injection. Topical administration would be a more effective method, but ocular layers act as barriers drug diffusion. In research, we presented preparation characterization poly(pseudo)rotaxanes (PPRs) containing...
Clinicians face numerous challenges when delivering medications to the eyes topically because of physiological barriers, that can inhibit complete dose from getting intended location. Due their small size, ability deliver drugs different polarities simultaneously, and biocompatibility, liposomes hold great promise for ocular drug delivery. This study aimed develop characterise a dual loaded liposome formulation encapsulating Bevacizumab (BEV) Dexamethasone (DEX) possessed physicochemical...
Nitrogen-fixing heterocystous cyanobacteria are used as biofertilizer inoculants for stimulating plant growth but can also alleviate stress by exometabolite secretion. However, only a small number of studies have focused on elucidating the identity said bioactives because wide array exuded compounds. Here, we root hair assay (RHA) rapid programmed cell death (PCD) screening tool characterizing bioactivity Nostoc muscorum conditioned medium (CM) Arabidopsis thaliana tolerance. We found that...
Polymeric self-assemblies formed by non-covalent interactions such as hydrophobic interactions, hydrogen bonding, π-π stacking, host-guest and electrostatic have been utilised widely exhibit controlled release of encapsulated drug. Beside carrier-carrier small molecule amphiphiles exhibiting carrier-drug recently an area interest for cancer drug delivery, most the anti-tumour drugs are aromatic conjugated structure. In present study PEG-coumarin (PC) conjugates forming self-assembled...
The reversed phase liquid chromatographic (RP-HPLC) separation of small molecules using a polystyrene-co-divinylbenzene (PS-co-DVB) polyHIPE stationary phases housed within 1.0 mm i.d. silcosteel columns is presented this study. A 90% PS-co-DVB was covalently attached to the walls column housing by prior wall modification with 3-(trimethoxysilyl) propyl methacrylate and could withstand operating backpressures in excess 200 bar at flow rate 1.2 mL/min. Permeability studies revealed that...
The naringenin (NAR)-impregnated hydrogel lenses (nesofilcon A material) were manufactured in this study with the feasibility to achieve controlled daily drug release. fabricated using a comparable commercial-standard process, utilizing injection molding and thermal curing approaches. NAR-loaded prepared by both direct entrapment 'soak release' methods. Their critical properties tested ISO standards commercial lenses. NAR was fully characterized studying its physical chemical stability...
When placed in the eye, contact lenses (CLs) disturb tear fluid and affect natural tribological behaviour of eye. The disruption mechanics between ocular tissues can increase frictional shear stress dryness, causing discomfort. Ultimately, continuous CLs wear trigger inflammation which is particularly critical for people suffering from dry In this work, a double strategy was followed to obtain therapeutic daily disposable eye: hydroxyethyl methacrylate (HEMA) based hydrogel coated with two...
The paper presents an in-depth analysis on the crystallization kinetics of Pebax–graphene composites when processed with and without supercritical fluid carbon dioxide (scCO2) assisted extrusion at various graphene loading concentrations. Crystallization behavior was understood using Avrami model for isothermal conditions Avrami, Ozawa, combined Avrami-Ozawa non-isothermal conditions. results from suggest that crystal structure transformed two-dimensional to three-dimensional scCO2. overall...
Conventional methods for screening stress-tolerant cereal varieties rely on expensive, labour-intensive field testing and molecular biology techniques. Here, we use the root hair assay (RHA) as a rapid tool to identify at early seedling stage. Wheat barley seedlings had stress applied, response quantified in terms of programmed cell death (PCD), viability necrosis. Heat shock experiments seven showed that winter spring could be partitioned into their two distinct seasonal groups based PCD...
This study details the formation and characterisation of a novel nicotinamide adenine dinucleotide (NAD+)-associated polymeric nanoparticle system. The development polyelectrolyte complex (PEC) composed two natural polyelectrolytes, hyaluronic acid poly(L-lysine), an evaluation its suitability for NAD+ ocular delivery, primarily based on physicochemical properties in vitro release profile under physiological flow rates, were key focus. Following optimisation formulation method conditions...
Wet age-related macular degeneration (wAMD) is a chronic inflammation-associated neurodegenerative disease affecting the posterior part of eye in aging population. Aging results reduced functionality cells and tissues, including retina. Initiators inflammatory pathologic state wAMD may be result accumulation inevitable metabolic injuries associated with maintenance tissue homeostasis from young age to over 50. Apart this, risk factors like smoking, genetic predisposition, failure repair that...
Medical tubing used in minimally invasive devices presents a number of design considerations depending on the material used, requirements (such as sufficient stiffness, flexibility and biocompatibility) processing conditions. Currently, manufacturing industries adopt co-extrusion systems to meet specifications, by using multilayer configuration leading higher cost per device increased complexity. This paper investigates mechanical performance nanocomposites supercritical carbon dioxide...