Kevin Matheus Lima de Sarges
A5006213736- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- Long-Term Effects of COVID-19
- Vitamin C and Antioxidants Research
- Complement system in diseases
- Phagocytosis and Immune Regulation
- Inflammation biomarkers and pathways
- Medicinal Plants and Bioactive Compounds
- Immune Cell Function and Interaction
- Viral Infections and Vectors
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune and Inflammatory Disorders Research
- interferon and immune responses
Universidade Federal do Pará
2022-2025
The duration and severity of COVID-19 are related to age, comorbidities, cytokine synthesis. This study evaluated the impact these factors on patients with clinical presentations in a Brazilian cohort. A total 317 diagnosed were included; cases distributed according status as severe (n=91), moderate (n=56) mild (n=170). Of patients, 92 had acute at sample collection, 90 already recovered from without sequelae, 135 sequelae (long COVID syndrome). In group, form higher IL-6 levels (p=0.0260)....
Abstract The cGAS-STING pathway appears to contribute dysregulated inflammation during coronavirus disease 2019 (COVID-19); however, inflammatory factors related long COVID are still being investigated. In the present study, we evaluated association of cGAS and STING gene expression levels plasma IFN-α, TNF-α IL-6 with COVID-19 severity in acute infection COVID, based on analysis blood samples from 148 individuals, 87 61 post-COVID-19 period. Quantification was performed by real-time PCR,...
Interleukin-6 has been recognized as a major role player in COVID-19 severity, being an important regulator of the cytokine storm. Hence, evaluation influence polymorphisms key genes IL-6 pathway, namely IL6, IL6R, and IL6ST, may provide valuable prognostic/predictive markers for COVID-19. The present cross-sectional study genotyped three SNPs (rs1800795, rs2228145, rs7730934) at IL6. IL6R IL6ST genes, respectively, 227 patients (132 hospitalized 95 non-hospitalized). Genotype frequencies...
Introduction Mannose-binding lectin (MBL) promotes opsonization, favoring phagocytosis and activation of the complement system in response to different microorganisms, may influence synthesis inflammatory cytokines. This study investigated association MBL2 gene polymorphisms with plasma levels MBL cytokines COVID-19. Methods Blood samples from 385 individuals (208 acute COVID-19 117 post-COVID-19) were subjected real-time PCR genotyping. Plasma measurements performed by enzyme-linked...
The apoptotic molecule Fas and its ligand FasL are involved in the process of T-lymphocyte death, which may lead to lymphopenia, a characteristic severe coronavirus disease 2019 (COVID-19). In this study, we investigated influence polymorphisms FAS FASL genes, gene expression, plasma cytokine levels on COVID-19 severity long COVID occurrence. A total 116 individuals with 254 non-severe form were evaluated. post-COVID-19 period, samples from 196 67 people who did not have included. Genotyping...
Aiming to evaluate the role of ten functional polymorphisms in long COVID, involved major inflammatory, immune response and thrombophilia pathways, a cross-sectional sample composed 199 COVID (LC) patients cohort 79 COVID-19 whose follow-up by over six months did not reveal any evidence (NLC) were investigated detect genetic susceptibility COVID. Ten located thrombophilia-related genes genotyped real time PCR. In terms clinical outcomes, LC presented higher prevalence heart disease as...
The first case of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), in Brazil was diagnosed on February 26, 2020. Due to the important epidemiological impact COVID-19, present study aimed analyze specificity IgG antibody responses S1, S2 and N proteins SARS-CoV-2 different COVID-19 clinical profiles. This enrolled 136 individuals who were with or without based findings laboratory results classified as asymptomatic having mild, moderate disease....
Tumor necrosis factor (TNF) and interferon-gamma (IFNγ) are important inflammatory mediators in the development of cytokine storm syndrome (CSS). Single nucleotide polymorphisms (SNPs) regulate expression these cytokines, making host genetics a key prognosis COVID-19. In this study, we investigated associations TNF -308G/A IFNG +874T/A with We analyzed frequencies two control groups (CG: -308G/A, n = 497; +874T/A, 397), group patients COVID-19 (CoV, 222) among subgroups nonsevere (n 150)...
The IgG response against SARS-CoV-2 infection can persist for over six months (long response; LR). However, among 30% of those infected, the duration be as short three or less (short SR). present study assembled serological data on anti-SARS-CoV-2 two previous studies and integrated these results with plasmatic cytokine levels genetic profile 10 immune-relevant SNPs that were also previously published, along total IgG, IgA, IgM levels, allowing genetic, clinical, immunological,...
Abstract Interleukin-6 have been recognized as a major role player in COVID-19 severity, being an important regulator of cytokine storm. Hence, the evaluation influence polymorphisms key genes IL-6 pathway, namely IL6, IL6R and IL6ST , may provide valuable prognostic/predictive biomarkers on COVID-19. The present cross-sectional study genotyped three Single Nucleotide Polymorphisms - SNPs (rs1800795, rs2228145 rs7730934) at genes, respectively, 227 patients (132 hospitalized 95...