A5073802182- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Retinal Imaging and Analysis
- Spaceflight effects on biology
- Retinopathy of Prematurity Studies
- Corneal Surgery and Treatments
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Circadian rhythm and melatonin
- Spectroscopy Techniques in Biomedical and Chemical Research
- Optical Imaging and Spectroscopy Techniques
- Ocular and Laser Science Research
- Magnetic Properties and Applications
- Cell Image Analysis Techniques
- Retinal and Optic Conditions
- Neurogenesis and neuroplasticity mechanisms
- Optical Coherence Tomography Applications
- Microstructure and Mechanical Properties of Steels
- Retinoids in leukemia and cellular processes
- bioluminescence and chemiluminescence research
- Optical and Acousto-Optic Technologies
- Textile materials and evaluations
- Visual perception and processing mechanisms
- Birth, Development, and Health
Georgia Institute of Technology
2018-2023
Atlanta VA Health Care System
2020-2023
Emory University
2019-2023
The Wallace H. Coulter Department of Biomedical Engineering
2021-2023
Atlanta VA Medical Center
2021
Veterans Health Administration
2018
Experimental myopia in animal models suggests that bright light can influence refractive error and prevent myopia. Additionally, research indicates activation of rod pathways circadian rhythms may eye growth. In children, objective measures personal exposure, recorded by wearable sensors, have been used to examine the effects exposure on The effect time spent a broad range intensities childhood development is not known. This study aims evaluate dim myopia.We reanalyzed previously published...
Ocular all-trans retinoic acid (atRA) levels are influenced by visual cues, and exogenous atRA has been shown to increase eye size in chickens guinea pigs. However, it is not clear whether induces myopic axial elongation via scleral changes. Here, we test the hypothesis that will induce myopia alter biomechanics mouse.Male C57BL/6J mice were trained voluntarily ingest + vehicle (1% sugar, 25 mg/kg) (RA: n = 16 animals) or only (Ctrl: 14 animals). Refractive error (RE) ocular biometry...
Purpose: The sclera is believed to biomechanically influence eye size, facilitating the excessive axial elongation that occurs during myopigenesis. Here, we test hypothesis will be remodeled and exhibit altered biomechanics in mouse model of form-deprivation (FD) myopia, accompanied by retinoid concentrations, a potential signaling molecule involved process. Methods: Male C57 Bl/6J mice were subjected unilateral FD (n = 44 eyes), leaving contralateral untreated (contra; n 44). Refractive...
The effect of both compressive and tensile stresses up to 500lbf/in2 at various temperatures in the range 20–400°C on power loss, coercive force remanence two grades grain-oriented 3% silicon iron has been measured 50c/s. Increasing tension first reduces loss force, but tensions above a certain value are increased. degree improvement magnetic properties. obtained under depends grade material. stress causes rise monotonically; 400lbf/in2 gives an increase about 30% for better material 20%...
Purpose: Assessment of glaucomatous damage in animal models is facilitated by rapid and accurate quantification retinal ganglion cell (RGC) axonal loss morphologic change. However, manual assessment extremely time- labor-intensive. Here, we developed AxoNet 2.0, an automated deep learning (DL) tool that (i) counts normal-appearing RGC axons (ii) quantifies their morphometry from light micrographs. Methods: A DL algorithm was trained to segment the axoplasm myelin sheath using...
Measuring the biomechanical properties of mouse sclera is great interest: altered scleral are features many common ocular pathologies, and a powerful tool for studying genetic factors in disease, yet small size eye its thin make experimental measurements difficult. Here, poroelastic material model used to analyse data from unconfined compression testing both pig sclera, tensile modulus, compressive modulus permeability obtained at three levels strain. Values all were comparable previously...
Purpose: Scleral stiffening may protect against glaucomatous retinal ganglion cell (RGC) loss or dysfunction associated with ocular hypertension. Here, we assess the potential neuroprotective effects of two treatments designed to stiffen either entire posterior sclera only adjacent peripapillary in an experimental model glaucoma. Methods: Rat sclerae were stiffened vivo using genipin (crosslinking sclera) a regionally selective photosensitizer, methylene blue (stiffening juxtaperipapillary...
Purpose: A reference atlas of optic nerve (ON) retinal ganglion cell (RGC) axons could facilitate studies neuro-ophthalmic diseases by detecting subtle RGC axonal changes. Here we construct an for normotensive eyes in Brown Norway rats, widely used glaucoma research, and also develop/evaluate several novel metrics damage hypertensive eyes. Methods: Light micrographs entire ON cross-sections from were processed through a deep learning-based algorithm, AxoNet2.0, to determine morphological...
Abstract Measuring the biomechanical properties of mouse sclera is great interest, since altered scleral are features many common ocular pathologies, and a powerful species for studying genetic factors in disease. Here, poroelastic material model used to analyze data from unconfined compression testing both pig sclera, tensile modulus, compressive permeability obtained at three levels strain. Values all measured simultaneously by were comparable previously reported values tests specific each...
Myopia, or near-sightedness, is a common ocular condition in which the eye elongates excessively. Development of myopia associated with, and thought to be facilitated by, changes biomechanical properties sclera (the white part eye). We characterized scleral biomechanics mouse model using unconfirmed compression testing biphasic theory extract permeability, in- plane tensile modulus, through-plane compressive modulus. find that reduces in-plane modulus consistent with tissue remodeling. Such...