A5038352298- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and pharmacology of benzodiazepine derivatives
- Synthesis and Catalytic Reactions
- Coordination Chemistry and Organometallics
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Organic Chemistry Cycloaddition Reactions
- Organometallic Complex Synthesis and Catalysis
- Crystal structures of chemical compounds
- Cancer therapeutics and mechanisms
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Biochemical and Molecular Research
- Synthesis and biological activity
- Cancer Treatment and Pharmacology
- Fluorine in Organic Chemistry
- Multicomponent Synthesis of Heterocycles
- Chemical synthesis and pharmacological studies
- Advanced Synthetic Organic Chemistry
- Oxidative Organic Chemistry Reactions
- Synthesis and Characterization of Pyrroles
- Chemical Synthesis and Analysis
- Crystallography and molecular interactions
- Chemistry and Chemical Engineering
- Synthesis and Characterization of Heterocyclic Compounds
University of Warsaw
2023-2024
Peoples' Friendship University of Russia
2016-2024
Russian New University
2020-2024
Durham University
2021
ShanghaiTech University
2020
Riga Technical University
2020
A.E. Arbuzov Institute of Organic and Physical Chemistry
2020
A.E. Favorsky Irkutsk Institute of Chemistry
2020
Heinrich Heine University Düsseldorf
2019
The Z-alkene geometry is prevalent in various chemical compounds, including numerous building blocks, fine chemicals, and natural products. Unfortunately, established Mo, W, Ru Z-selective catalysts lose their selectivity at high temperatures required for industrial processes like reactive distillation, which limits synthetic applications. To address this issue, we develop a catalyst capable of providing Z-alkenes with under harsh conditions. Our research reveals dithiolate ligand that,...
A concise preparative IMDAV strategy for the synthesis of benzo-, carbocyclo-, and thienothiopheneisoindolecarboxylic acids, which display antifungal antibacterial activity, starting from readily available materials is proposed.
A series of 4,5-dibromo-2-(4-substituted phenyl)hexahydro-3a,6-epoxyisoindol-1(4H)-ones were synthesized by reaction the corresponding 2-(4-substituted phenyl)-2,3,7,7a-tetrahydro-3a,6-epoxyisoindol-1(6H)-ones with [(Me2NCOMe)2H]Br3 in dry chloroform under reflux for 3−5 h. In contrast to 4-F and 4-Cl substituents, one bromine atoms isoindole moiety behaves as a halogen bond donor formation intermolecular bonding 4-H, 4-Br 4-I analogues. Not only hydrogen bonds, but also Ha⋯Ha Ha⋯π types...
3-(Thien-2-yl)- and 3-(thien-3-yl)allylamines, readily accessible from the corresponding thienyl aldehydes, can interact with a broad range of anhydrides α,β-unsaturated acids chlorides (maleic, сitraconic, phenyl maleic anhydrides, сrotonyl сinnamyl chlorides, etc.) leading to formation thieno[2,3-f]isoindole core. Usually, reaction sequence involves three successive steps: acylation nitrogen atom initial allylamine, intramolecular Diels–Alder vinylarenе (IMDAV) reaction, final...
Diversely substituted, partially saturated benzo[f]isoindole-4-carboxylic acids were synthesized by a new three-component reaction (3CR) starting from cinnamic amines (3-arylallylamines), maleimides, and maleic anhydride. The process consists of N-acylation the anhydride, intramolecular [4 + 2] cycloaddition in vinylarenes (the IMDAV reaction), concluding Alder-ene between Diels-Alder intermediates maleimides. All steps proceed highly regio- stereoselective manner, furnishing five adjacent...
In the title compound, C 15 H Br 2 NO , two bridged tetrahydrofuran rings adopt envelope conformations with O atom as flap. The pyrrolidine ring also adopts an conformation spiro crystal, molecules are linked into dimers by pairs of C—H...O hydrogen bonds, thus generating R (18) rings. crystal packing is dominated H...H, Br...H, H...π and Br...π interactions. One atoms disordered over sites occupation ratio 0.833 (8):0.167 (8).
The title compound, C 24 H N 2 O 5 S, crystallizes with two independent molecules ( A and B ) in the asymmetric unit. In central ring systems of both molecules, tetrahydrofuran rings adopt envelope conformations, pyrrolidine a twisted-envelope conformation six-membered is boat conformation. , nine-membered groups attached to system are essentially planar (r.m.s. deviations 0.002 0.003 Å, respectively). They form dihedral angles 64.97 (9) 56.06 (10)°, respectively, phenyl rings. crystal,...
We have developed an effective two-step approach towards the synthesis of functionalized hexahydropyrano[3,4-c]pyrrole-1,6-diones from readily accessible 3-thienylsubstituted allylamines and maleic anhydride. This conversion begins with initial N-acylation anhydride, followed by intramolecular oxo-Diels–Alder reaction (IMODA), which is accompanied tautomerization step, ends formation saturated pyrano[3,4-c]pyrroles.
The title compounds C 24 H 21 NO 3 S, I , and 4 II are the products of IMDAV reaction between phenylmaleic anhydride thienyl(furyl)allylamines. Their molecular structures comprise fused tricyclic systems containing thiophene, cyclohexene pyrrolidine rings ( ) or furan, ). central in both adopt slightly twisted boat envelope conformations, respectively. dihedral angles basal plane ring thiophene (in furan 22.74 (16) 26.29 (5)°, nitrogen atom has practically planar environment [the sums bond...