A5044135900- Vitamin D Research Studies
- Electrolyte and hormonal disorders
- Hormonal Regulation and Hypertension
- Macrophage Migration Inhibitory Factor
- Vitamin C and Antioxidants Research
- Galectins and Cancer Biology
- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Adrenal Hormones and Disorders
- Autophagy in Disease and Therapy
Oulu University Hospital
2017-2025
University of Oulu
2017-2025
Low plasma level of 25-hydroxyvitamin D (25-OH-D), namely vitamin deficiency, is associated with obesity and weight loss improves 25-OH-D status. However, the mechanism behind obesity-induced deficiency remains unclear. Here, we report that suppresses expression cytochrome P450 (CYP) 2R1, main 25-hydroxylase, in both mice humans. In humans, induced by gastric bypass surgery increased CYP2R1 s.c. adipose tissue suggesting recovery after suppression. At same time, CYP27B1, 1α-hydroxylase, was...
Low 25-hydroxyvitamin D levels correlate with the prevalence of diabetes; however, mechanisms remain uncertain. Here, we show that nutritional deprivation–responsive regulate vitamin metabolism. Both fasting and diabetes suppressed hepatic cytochrome P450 (CYP) 2R1, main 25-hydroxylase responsible for first bioactivation step. Overexpression coactivator peroxisome proliferator–activated receptor γ 1-α (PGC-1α), induced physiologically by pathologically in diabetes, resulted dramatic...
LIM and Src homology 3 (SH3) protein 2 (LASP2) is a small focal adhesion first identified as splice variant of the nebulette gene (Nebl). As newest member nebulin family, regulation function LASP2 remain largely unknown. Our previous RNA-sequencing results Nebl one most highly induced genes in mouse liver response to activation pregnane X receptor (PXR). In this study, we investigated phenomenon further show that PXR induces Lasp2 instead Nebl, which partially use same exons. was found be...
Abstract Vitamin D deficiency [ie, low plasma 25-hydroxyvitamin (25-OH-D)] associates with the prevalence of metabolic diseases including type 1 diabetes; however, molecular mechanisms are incompletely understood. Recent studies have indicated that both fasting and suppress cytochrome P450 (CYP) 2R1, major hepatic vitamin 25-hydroxylase. We specifically studied effect a mouse model diabetes on regulation Cyp2r1 status. show streptozotocin-induced in mice suppresses expression liver. While...