A5076690111- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- 3D Printing in Biomedical Research
- Ocular Infections and Treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Silk-based biomaterials and applications
- Ocular Surface and Contact Lens
- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- Antimicrobial agents and applications
- Neuroscience and Neural Engineering
- Diet and metabolism studies
- Corneal Surgery and Treatments
- Muscle activation and electromyography studies
- Cardiomyopathy and Myosin Studies
- Muscle Physiology and Disorders
- Microbial Metabolic Engineering and Bioproduction
- Hemostasis and retained surgical items
- Tissue Engineering and Regenerative Medicine
- Antimicrobial Peptides and Activities
- Planarian Biology and Electrostimulation
- Natural Fiber Reinforced Composites
- Adipose Tissue and Metabolism
National University of Singapore
2018-2022
Singapore Eye Research Institute
2020
Organs-on-chips (OoCs) are systems containing engineered or natural miniature tissues grown inside microfluidic chips. To better mimic human physiology, the chips designed to control cell microenvironments and maintain tissue-specific functions. Combining advances in tissue engineering microfabrication, OoCs have gained interest as a next-generation experimental platform investigate pathophysiology effect of therapeutics body. There many examples there applications, making it difficult for...
Burn wounds are susceptible to microbial invasion from both resident and exogenous bacteria, which becomes a critical public health issue causes substantial economic burden. There is perceived demand produce new antimicrobial wound dressings that hinder bacterial colonization while accelerating the healing process hence would provide an improved standard of care for patients. Since ancient times, herbal extracts medicinally important plants have extensively been used treating burn injuries....
Different strategies to design antimicrobial contact lenses and lens cases.
Electrospun fibers have emerged as promising materials in the field of biomedicine, due to their superior physical and cell supportive properties. In particular, electrospun mats are being developed for advanced wound dressing applications. Such applications require firers possess excellent antimicrobial properties order inhibit potential microbial colonization from resident non-resident bacteria. this study, we Poly-ε-Caprolactone /gelatin hybrid composite loaded with natural herbal extract...
Effect of chondroitin sulphate incorporated PCL/gelatin as blends or core–shell composite nanofibres are compared in terms their biocompatibility for skin cells and wound healing porcine model partial thickness burns.
Introduction: In search for cross-linkers with multifunctional characteristics, the present work investigated utility of quaternary ammonium organosilane (QOS) as a potential cross-linker electrospun collagen nanofibers. We hypothesized that ions improve electrospinnability by reducing surface tension and confer antimicrobial properties, while formation siloxane after alkaline hydrolysis could cross-link stimulate cell proliferation. Materials methods: QOS nanofibers were incorporating...
Designing biocompatible nanofibrous mats capable of preventing microbial colonization from resident and nosocomial bacteria for an extended period remains unmet clinical need. In the present work, we designed antibiotic free durable antimicrobial nanofiber by taking advantage synergistic interactions between polydopamine (pDA) metal ions with varying degree properties (Ag+, Mg2+, Ca2+, Zn2+). Microscopic analysis showed successful pDA-mediated cross-linking gelatin nanofibers, which further...
The adipose tissue is a metabolically active endocrine organ with dynamic secretome that known to be implicated in metabolic disorders. Various studies have demonstrated detrimental downstream endocrinal effects of dysfunctional on other tissues, such as skeletal muscle and liver. In vitro 'Adipose-on-Chip' (AOC) models been developed an animal-alternative experimental platform mimic dysfunction diseases. However, existing AOCs not modeled both overtime lipid accumulation inflammation...