A5001576774- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cellular Mechanics and Interactions
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- Neurofibromatosis and Schwannoma Cases
- Erythrocyte Function and Pathophysiology
- Cancer-related gene regulation
- Cancer therapeutics and mechanisms
- S100 Proteins and Annexins
- Photodynamic Therapy Research Studies
- Diet and metabolism studies
- Cardiac Structural Anomalies and Repair
- Peptidase Inhibition and Analysis
- Virus-based gene therapy research
- RNA Research and Splicing
- Signaling Pathways in Disease
- HVDC Systems and Fault Protection
- Clusterin in disease pathology
University of Gothenburg
2022-2024
Sahlgrenska University Hospital
2022-2024
Region Västra Götaland
2024
Centro de Investigación Biomédica en Red de Cáncer
2019-2023
Universitat de València
2019-2023
INCLIVA Health Research Institute
2019-2023
Instituto de Salud Carlos III
2020-2023
Hospital Universitari i Politècnic La Fe
2023
Universitat Politècnica de València
2023
Ministry of Economy, Industry and Competitiveness
2023
Neuroblastic tumours (NBTs) are paediatric solid derived from embryonic neural crest cells which harbour their own cancer stem (CSC). There is evidence indicating that CSC may be responsible for tumour progression, chemotherapy resistance and recurrence in NBTs. Oct4 a transcription factor plays key role mammal development cell fate regulation. The aim of the study to elucidate clinical significance NBTs.We studied expression 563 primary NBTs using digital image quantification. Chi-square...
Abstract Telomerase-negative tumors maintain telomere length by alternative lengthening of telomeres (ALT), but the underlying mechanism behind ALT remains poorly understood. A proportion aggressive neuroblastoma (NB), particularly relapsed tumors, are positive for (ALT+), suggesting that a better dissection could lead to novel therapeutic opportunities. TERRA, long non-coding RNA (lncRNA) derived from ends, localizes in R-loop-dependent manner and plays crucial role maintenance. Here we...
Insights into host-virus interactions during SARS-CoV-2 infection are needed to understand COVID-19 pathogenesis and may help guide the design of novel antiviral therapeutics. N6-Methyladenosine modification (m6A), one most abundant cellular RNA modifications, regulates key processes in metabolism stress response. Gene expression profiles observed postinfection with different variants show changes genes related catabolism, including m6A readers erasers. We found that causes a loss RNAs,...
Vitronectin is a multifunctional glycoprotein known in several human tumors for its adhesive role processes such as cell growth, angiogenesis and metastasis. In this study, we examined vitronectin expression neuroblastoma to investigate whether molecule takes part cell-cell or cell-extracellular matrix interactions that may confer mechanical properties promote tumor aggressiveness.We used immunohistochemistry image analysis tools characterize test prognostic value 91 patients. To better...
Abstract Three-dimensional (3D) bioprinted culture systems allow to accurately control microenvironment components and analyze their effects at cellular tissue levels. The main objective of this study was identify, quantify localize the physical-chemical communication signals between tumor cells surrounding biomaterial stiffness over time, defining how aggressiveness increases in SK-N-BE(2) neuroblastoma (NB) cell line. Biomimetic hydrogels with cells, methacrylated gelatin increasing...
Increased tissue stiffness is a common feature of malignant solid tumors, often associated with metastasis and poor patient outcomes. Vitronectin, as an extracellular matrix anchorage glycoprotein related to stiff matrix, present in particularly increased quantity specific distribution high-risk neuroblastoma. Furthermore, cells can sense transform the proprieties into chemical signals through mechanotransduction, genotypic changes are possible.
Tumors are complex networks of constantly interacting elements: tumor cells, stromal immune and stem blood/lympathic vessels, nerve fibers extracellular matrix components. These elements can influence their microenvironment through mechanical physical signals to promote cell growth. To get a better understanding biology, cooperation between multidisciplinary fields is needed. Diverse mathematic computations algorithms have been designed find prognostic targets enhance diagnostic assessment....
Patient-derived cancer 3D models are a promising tool that will revolutionize personalized therapy but require previous knowledge of optimal cell growth conditions and the most advantageous parameters to evaluate biomimetic relevance monitor efficacy. This study aims establish general guidelines on model characterization phenomena, focusing neuroblastoma. We generated gelatin-based scaffolds with different stiffness performed SK-N-BE(2) SH-SY5Y aggressive neuroblastoma cultures, also...
Digital pathology and artificial intelligence are promising emerging tools in precision oncology as they provide more robust reproducible analysis of histologic, morphologic topologic characteristics tumor cells the surrounding microenvironment. This study aims to develop digital image workflows for therapeutic assessment preclinical vivo models. For this purpose, we generated pipelines that enable automatic detection quantification vitronectin αvβ3 heterotopic high-risk neuroblastoma...
Abstract Neuroblastoma (NB) is the most common extracranial childhood cancer, caused by improper differentiation of developing trunk neural crest cells (tNCC) in sympathetic nervous system. The N 6 -methyladenosine (m A) epitranscriptomic modification controls post-transcriptional gene expression but mechanism which m A methyltransferase complex METTL3/METTL14/WTAP recruited to specific loci remains be fully characterized. We explored whether epitranscriptome could fine-tune regulation...
BackgroundThe vascular heterogeneity of glioblastomas (GB) remains an important area research, since tumor progression and patient prognosis are closely tied to this feature. With study, we aim identify gene expression profiles associated with MRI-defined vascularity investigate its relationship prognosis.MethodsThe study employed MRI parameters calculated DSC Perfusion Quantification ONCOhabitats glioma analysis software RNA-seq data from the TCGA-GBM project dataset. In our had a total 147...
Abstract Telomerase-negative tumors maintain telomere length by alternative lengthening of telomeres (ALT), but the underlying mechanism behind ALT remains poorly understood. A proportion aggressive neuroblastoma (NB), particularly relapsed tumors, are positive for (ALT+), suggesting that a better dissection could lead to novel therapeutic opportunities. TERRA, long non-coding RNA (lncRNA) derived from ends, localizes in R-loop-dependent manner and plays crucial role maintenance. Here we...
ABSTRACT Host-viral interactions during SARS-CoV-2 infection are needed to understand COVID-19 pathogenesis and may help guide the design of novel antiviral therapeutics. N 6 -methyladenosine modification (m A), one most abundant cellular RNA modifications, regulates key processes in metabolism a stress response. Gene expression profiles observed post-infection with different variants show changes genes related catabolism, including m A readers erasers. We found that caused loss RNAs,...
Abstract Tumor heterogeneity is a key hallmark and major cause of therapeutic resistance in glioblastoma (GBM) patients. To characterize this heterogeneity, the automatic method ONCOhabitats delineate four habitats within lesion using artificial intelligence analysis perfusion magnetic resonance imaging (MRI): high angiogenic tumor (HAT), low (LAT), infiltrated peripheral edema (IPE), vasogenic (VPE). BIOhabitats has been successfully implemented two Spanish hospitals, with purpose...
Background: The vascular heterogeneity of High-Grade Gliomas (HGG) remains an important area research, since tumor progression and patient prognosis are closely tied to this feature. With study, we aim identify gene expression profiles associated with MRI-defined vascularity investigate its relationship prognosis.Methods: study employed MRI parameters calculated DSC Perfusion Quantification ONCOhabitats glioma analysis software RNA-seq data from the TCGA-GBM project dataset. In our had a...
Abstract Background Increased tissue stiffness is a common feature of malignant solid tumors, often associated with metastasis and poor patient outcomes. Vitronectin, as an extracellular matrix anchorage glycoprotein related to stiff matrix, present in particularly increased quantity specific distribution high-risk neuroblastoma. Furthermore, cells can sense transform the proprieties into chemical signals through mechanotransduction, genotypic changes are possible. Methods We have applied...
Abstract Background: Increased tissue stiffness is a common feature of malignant solid tumors, often associated with metastasis and poor patient outcomes. Vitronectin, as an extracellular matrix anchorage glycoprotein related to stiff matrix, present in particularly increased quantity specific distribution high-risk neuroblastoma. Furthermore, cells can sense transform the proprieties into chemical signals through mechanotransduction, genotypic changes are possible. Methods: We applied high...