A5075194025- Bacterial Genetics and Biotechnology
- Bacteriophages and microbial interactions
- RNA and protein synthesis mechanisms
- Neurobiology and Insect Physiology Research
- Force Microscopy Techniques and Applications
- Probiotics and Fermented Foods
- Plant Molecular Biology Research
- Physiological and biochemical adaptations
- Genomics and Phylogenetic Studies
University of Münster
2021-2023
To reshape neuronal connectivity in adult stages, Drosophila sensory neurons prune their dendrites during metamorphosis using a genetic degeneration program that is induced by the steroid hormone ecdysone. Metamorphosis nonfeeding stage imposes metabolic constraints on development. We find AMP-activated protein kinase (AMPK), regulator of energy homeostasis, cell-autonomously required for dendrite pruning. AMPK activated ecdysone and promotes oxidative phosphorylation pyruvate usage, likely...
Antibiotic resistance of pathogenic bacteria needs to be urgently addressed by the development new antibacterial entities. Although prokaryotic cell wall comprises a valuable target for this purpose, novel wall-active antibiotics is mostly missing today. This mainly caused hindrances in assessment isolated enzymes co-dependent murein synthesis machineries, e.g., elongasome and divisome. We therefore present imaging methodologies evaluate inhibitors bacterial high-resolution atomic force...
Abstract Antibiotic resistance of pathogenic bacteria needs to be urgently addressed by the development new antibacterial entities. Although prokaryotic cell wall comprises a valuable target for this purpose, novel wall-active antibiotics is mostly missing today. This mainly caused hinderances in assessment isolated enzymes co-dependent murein synthesis machineries, e.g. elongasome and divisome. We therefore present imaging methodologies evaluate inhibitors bacterial high-resolution atomic...