A5088791694- Analytical Chemistry and Chromatography
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Mass Spectrometry Techniques and Applications
- Mitochondrial Function and Pathology
- Forensic Toxicology and Drug Analysis
- Airway Management and Intubation Techniques
- COVID-19 and healthcare impacts
- Enhanced Recovery After Surgery
- Alzheimer's disease research and treatments
- Drug Transport and Resistance Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Advanced Proteomics Techniques and Applications
- Microbial Metabolic Engineering and Bioproduction
- Metabolomics and Mass Spectrometry Studies
- Sirtuins and Resveratrol in Medicine
- Plant Toxicity and Pharmacological Properties
- Ultrasound in Clinical Applications
- Medical Malpractice and Liability Issues
- Cardiovascular Health and Disease Prevention
- Trauma and Emergency Care Studies
- Clostridium difficile and Clostridium perfringens research
- Genetic Neurodegenerative Diseases
- Delphi Technique in Research
- Microscopic Colitis
Shimadzu (Japan)
2024
Shimadzu (United Kingdom)
2021-2024
Institut de Virologie
2021
Stryker (United States)
2018-2020
Western Michigan University
2018-2020
University of Leeds
2017-2019
Bristol Royal Hospital for Children
2016-2018
Mayo Clinic in Florida
2016
In Alzheimer's disease (AD), the accumulation and deposition of amyloid-β (Aβ) peptides in brain is a central event. Aβ cleaved from amyloid precursor protein (APP) by β-secretase γ-secretase mainly neurons. Although mutations inAPP,PS1, orPS2cause early-onset familial AD,ABCA7encoding ATP-binding cassette transporter A7 one susceptibility genes for late-onset AD (LOAD), which itsloss-of-functionvariants increase risk. ABCA7 homologous to major lipid ABCA1 highly expressed neurons microglia...
Summary In 2011, the Fourth National Audit Project ( NAP 4) reported high rates of airway complications in adult intensive care units (ICUs), including death or brain injury, and recommended preparation for difficulty, immediately available difficult equipment routine use waveform capnography monitoring. More than 80% UK have subsequently changed practice. Undetected oesophageal intubation has recently been listed as a ‘Never Event’ practice, with mandated. We investigated whether NAP4...
The use of differential mobility spectrometry at low pressure coupled to liquid chromatography-mass (LC-vDMS-MS) was investigated for the analysis thirteen drugs abuse (DoA) including: cocaine, ecgonine methyl ester, cocaethylene, benzoylecgonine, norcocaine, tramadol, isomeric pairs metabolites; O-desmethyl-cis-tramadol and N-desmethyl-cis-tramadol, cannabinoids; Δ9-tetrahydrocannabinol, Δ9-tetrahydrocannabidiol, 11-hydroxy-Δ9-tetrahydrocannabinol, 11-nor-9carboxy-Δ9-tetrahydrocannabinol,...
Abstract The use of differential mobility spectrometry at low pressure coupled to liquid chromatography‐mass (LC‐vDMS‐MS) was investigated for the analysis 13 drugs abuse (DoA) including following: cocaine, ecgonine methyl ester, cocaethylene, benzoylecgonine, norcocaine, tramadol, isomeric pairs metabolites; O ‐desmethyl‐cis‐tramadol and N ‐desmethyl‐cis‐tramadol, cannabinoids: Δ 9 ‐tetrahydrocannabinol, ‐tetrahydrocannabidiol, 11‐hydroxy‐Δ 11‐nor‐9carboxy‐Δ ‐tetrahydrocannabinol...
The benefit of combining liquid chromatography (LC), supercritical fluid (SFC) and vacuum Differential Mobility Spectrometry - Mass (vDMS-MS) was investigated for the analysis fourteen diastereomeric pyrrolizidine alkaloids (PA); intermedine, echinatine, lycopsamine, indicine, intermedine-N-oxide, echinatine-N-oxide, indicine-N-oxide, lycopsamine-N-oxide, senecivernine, senecionine, jacobine, senecivernine-N-oxide, senecionine-N-oxide, retrorsine. mobile phase composition (15-100% MeOH ACN),...
Amyloid diseases represent a growing social and economic burden in the developed world. Understanding assembly pathway inhibition of amyloid formation is key to developing therapies treat these diseases. The neurodegenerative condition Machado–Joseph disease characterised by self-aggregation protein ataxin-3. Ataxin-3 consists globular N-terminal Josephin domain, which can aggregate into curvilinear protofibrils, an unstructured, dynamically disordered C-terminal domain containing three...
Fecal microbiota transplantation (FMT) re-emerged over the last decade, primarily in response to escalating problem of health-care-associated Clostridium difficile (CD) infection (CDI). Increasing virulence and antibiotic resistance CD prompted intensified efforts broaden therapeutic options for this emerging health threat. It is well established that homeostasis intestinal flora (or microbiota) critical human well-being. Introduction misuse various health-care related interventions,...
The effect of LC mobile phase composition and flow rate (2-50 µL/min) on mobility behavior in vacuum differential spectrometry (vDMS) was investigated for electrosprayed isobaric antidepressant drugs (AD); amitriptyline, maprotiline, venlafaxine; structurally related antidepressants nortriptyline, imipramine, desipramine. While at 2 µL/min, no difference compensation voltage observed with methanol acetonitrile, 50 acetonitrile used elution analytes enabled the selectivity separation to be...
Orbital frequency analyzer (OFA) is one of the electrostatic ion trap mass analysers for FTMS, which offers ultrahigh resolution and high charge capacity. In order to analyze multiply charged proteins other large biological particles by means detection spectrometry, a data processing algorithm was created suit image signal nonharmonic waveform nature. The capable detecting collisions between ions residual gas molecules, determine lifetime ions, evaluate values having above threshold. With...
<h3>Background and aims</h3> Human factors (HF) is the science of human performance within a given system.<sup>1</sup> It was adopted by healthcare from safety critical industries to improve patient safety. HF training recommended General Medical Council (GMC), World Health Organisation Royal Colleges.<sup>2 3</sup> Despite importance safety, there relative paucity research on how incorporate perspective existing reporting systems such as Datix. <h3>Aims</h3> To analyse contribution Datix...