A5101861555- Cancer, Hypoxia, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Melanoma and MAPK Pathways
- MicroRNA in disease regulation
- Medical Imaging Techniques and Applications
- Cutaneous Melanoma Detection and Management
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Bone Metabolism and Diseases
- Dermatology and Skin Diseases
- Skin Protection and Aging
- Prostate Cancer Treatment and Research
- Extracellular vesicles in disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Cells and Metastasis
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- TGF-β signaling in diseases
- Allergic Rhinitis and Sensitization
- Mast cells and histamine
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Circular RNAs in diseases
Case Western Reserve University
2017-2025
N.N. Alexandrov National Cancer Centre
2021
Krasnoyarsk State Medical University
2017-2019
The chondrogenic differentiation of mesenchymal stem cells (MSCs) is mediated by transcription factors and small noncoding RNAs such as microRNAs (miRNAs). Each miRNA initially transcribed a long transcript, which matures to produce -5p -3p strands. It widely believed that the mature functional from any given pre-miRNA, usually strand, functional, while opposing strand degraded. However, recent cartilage literature started show strands for few miRNAs. This study aimed at examining both two...
Summary MicroRNAs are involved in the control of tumour progression and metastatic cascade dynamics. However, role microRNAs distant organ reorganization at premetastatic stage is less clear, although process niche formation a crucial event according to modern concepts dissemination. The present study was investigate expression levels miR‐155, miR‐21, miR‐205 miR‐let7b, as well that their target genes, organs melanoma metastasis stage. both pro‐oncogenic miR‐155 suppressive were found be...
Abstract Background: Multiple myeloma (MM) is an incurable cancer of plasma cells. MM thrives in the bone marrow tumor microenvironment (TME) where several factors sustain growth and viability. TGF-β a multi-functional cytokine elaborated by cells (BM) TME. stimulates progression through promotion catabolic remodeling, IL-6 secretion Th17 T cell development, which act concert to induce osteolytic disease, immune suppression progression. Therefore, we evaluated anti-MM therapeutic potential...
Objective: The Melanoma Screening Day Campaign started in the Russian Federation 2006. In present study, we analyzed 2015-2016 survey questionnaire data acquired from screened individuals city of Krasnoyarsk eastern Siberia, which has a population one million, order to understand level awareness regarding melanoma/ skin cancer prevention and early diagnosis. Methods: Individuals were enrolled screening campaign by mass media advertising. Free whole-body examinations provided doctors,...
[11C]methionine ([11C]Met) was used for cancer imaging based on upregulated amino acid transport and protein synthesis in different tumor types. However, the short half-life of 11C decay limited further clinical development [11C]Met. Synthetic analog anti-1-amino-3-[18F]fluoro-cyclobutyl-1-carboxylic ([18F]FCABC) developed FDA-approved PET recurrent prostate cancer. This study investigated "repurposed" [18F]FACBC primary liver such as hepatocellular carcinoma (HCC) comparison with [11C]Met...
Prostate specific membrane antigen (PSMA)-targeted radioligand therapies represent a highly effective treatment for metastatic prostate cancer. However, high and sustain uptake of PSMA-ligands in the salivary glands led to dose limiting dry mouth (xerostomia), especially with α-emitters. The expression PSMA histologic analysis couldn't directly explain toxicity, suggesting potential off-target mediator uptake. In this study, we set out search possible non-PSMA protein(s) glands.
Acral lentiginous melanoma type is characterized by specific clinical and histologic features therefore it requires a special approach to diagnosis therapy. c-KIT oncogene mutations are frequent in this tumor accounting up 23% of all cases. The presence exons gene indicates therapy tyrosine kinase inhibitors. case acral with the analysis mutational status 11th exon that considered as one most significant sites, presented. functional role mentioned substitutes was not described previously...
МНОЖЕСТВЕННЫЙ МЕЛКООЧАГОВЫЙ ПЕРИПОРТАЛЬНЫЙ СТЕАТОЗ ПРИ СТАТИНОВОМ ГЕПАТИТЕ, МИМИКРИРУЮЩИЙ МЕТАСТАЗЫ В ПЕЧЕНИКолобанова Е
Tumor microenvironment is known to be an active participant of tumor development. functional cell community interacting with cancer cells and promoting proliferation, invasion metastasis cells. In the article features Ki-67 NFE2L2 expression levels in target organs melanoma premetastatic phase are investigated. Increased Ki-67expression lung tissue, liver kidneys decreased liverandkidneys can markers structural reorganization
191 Background: Castration-resistant prostate cancer occurs in part due to increased tumor tissue testosterone (T) and dihydrotestosterone (DHT) that sustain growth. T DHT are converted inactive T- DHT-glucuronide (T/DHT-G) by uridine 5'-diphospho-glucuronosyltransferase family genes (UGT2B15 UGT2B17) glucuronidation-competent cells excreted, but not glucuronidation-deficient cells. Thus, low glucuronidation activity enables tumors preserve androgens, which increases hormone treatment...
This review presents analysis of experimental models atopic dermatitis, psoriasis, skin symptoms autoimmune systemic connective tissue diseases, and blistering diseases. Presented in the are dermatitis which reproduce various stages types disease that allows investigation pathogenesis. Atopic can develop spontaneously Nc/Nga mice. There initiated by monoclonal IgE injection or epicutant sensitization under dermal barrier disfunction imitation. Genetically modified - transgenic knockout mice...