A5007303067- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Obstructive Sleep Apnea Research
- Asthma and respiratory diseases
- Radiomics and Machine Learning in Medical Imaging
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cervical Cancer and HPV Research
- Airway Management and Intubation Techniques
- Neonatal Respiratory Health Research
- Kruppel-like factors research
- Atomic and Subatomic Physics Research
- Pulmonary Hypertension Research and Treatments
- COVID-19 diagnosis using AI
- Cystic Fibrosis Research Advances
- Voice and Speech Disorders
- Respiratory and Cough-Related Research
- Transplantation: Methods and Outcomes
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Respiratory viral infections research
University of Liège
2021-2025
Flemish Radio and Television Broadcasting Organisation
2025
Fluidda (Belgium)
2012-2021
Fluidda (United States)
2010-2019
Antwerp University Hospital
2006-2016
University of Antwerp
2006-2014
Removing the bias and variance of multicentre data has always been a challenge in large scale digital healthcare studies, which requires ability to integrate clinical features extracted from acquired by different scanners protocols improve stability robustness. Previous studies have described various computational approaches fuse single modality datasets. However, these surveys rarely focused on evaluation metrics lacked checklist for harmonisation studies. In this systematic review, we...
To compare the results obtained by using numerical flow simulations with of combined single photon emission computed tomography (SPECT) and (CT) to demonstrate importance correct boundary conditions for methods account large amount interpatient variability in airway geometry.This study was approved all relevant institutional review boards. All patients gave their signed informed consent. In this study, six mild asthma (three men; three women; overall mean age, 46 years ± 17 [standard...
Abstract Segmentation of anatomical structures is valuable in a variety tasks, including 3D visualization, surgical planning, and quantitative image analysis. Manual segmentation time-consuming deals with intra inter-observer variability. To develop deep-learning approach for the fully automated inner ear MRI, U-net was trained on 944 MRI scans manually segmented ears as reference standard. The model validated an independent, multicentric dataset consisting 177 from three different centers....
The aim of our study was to determine the potential role CT-based radiomics in predicting treatment response and survival patients with advanced NSCLC treated immune checkpoint inhibitors. We retrospectively included 188 PD-1/PD-L1 inhibitors from two independent centers. Radiomics analysis performed on pre-treatment contrast-enhanced CT. A delta-radiomics also conducted a subset 160 who underwent follow-up CT after 2 4 cycles. Linear random forest (RF) models were tested predict at 6 months...
In anticipation of potential future pandemics, we examined the challenges and opportunities presented by COVID-19 outbreak. This analysis highlights how artificial intelligence (AI) predictive models can support both patients clinicians in managing subsequent infectious diseases, legislators policymakers could these efforts, to bring learning healthcare system (LHS) from guidelines real-world implementation. report chronicles trajectory pandemic, emphasizing diverse data sets generated...
The intratracheal instillation of bleomycin in mice induces early damage to alveolar epithelial cells and development inflammation followed by fibrotic tissue changes represents the most widely used model pulmonary fibrosis investigate human IPF. Histopathology is gold standard for assessing lung rodents, however it precludes repeated longitudinal measurements disease progression does not provide information on spatial temporal distribution damage. Here we investigated use Micro-CT technique...
The efficacy of inhaled corticosteroids (ICS) in moderately severe COPD patients remains unclear. At the same time, use extrafine particles is a topic ongoing research.This study assessed effect ICS steroid-naïve mild and reducing dose more previously using when switching to an particle BDP/F formulation (Foster Modulite technology, Chiesi Pharmaceutici, Parma, Italy).Novel functional respiratory imaging (FRI) methods, consisting multi-slice CT scans Computational Fluid Dynamics, were used...
Upper airway stimulation has been shown to be an effective treatment for some patients with obstructive sleep apnea. However, the mechanism by which hypoglossal nerve increases upper caliber is not clear. Therefore, objective of this study was identify action stimulation. We hypothesized that, stimulation, responders would show greater opening in retroglossal (base tongue) region, hyoid movement toward mandible, and anterior motion posterior, inferior region tongue compared nonresponders....
The coronavirus disease 2019 (COVID-19) outbreak has reached pandemic status. Drastic measures of social distancing are enforced in society and healthcare systems being pushed to beyond their limits. To help the fight against this threat on human health, a fully automated AI framework was developed extract radiomics features from volumetric chest computed tomography (CT) exams. detection model dataset 1381 patients (181 COVID-19 plus 1200 non COVID control patients). A second, independent...
Sarcoidosis and lymphoma often share common features on <sup>18</sup>F-FDG PET/CT, such as intense hypermetabolic lesions of lymph nodes multiple organs. We aimed at developing validating radiomics signatures to differentiate sarcoidosis from Hodgkin (HL) diffuse large B-cell (DLBCL) lymphoma. <b>Methods:</b> retrospectively collected 420 patients (169 sarcoidosis, 140 HL 111 DLBCL) who underwent a pretreatment PET/CT the University Hospital Liege. The studies were randomly distributed 4...
Context: Asthma affects 20 million Americans resulting in an economic burden of approximately $18 billion the US alone (Allergies and Foundation 2000; National Center for Environmental Health (NCEH) 1999). Research studies based on differences patient-specific airway morphology asthma associated effect deposition inhaled aerosols are currently not available literature. Therefore, role morphological variations such as upper (extrathoracic) occlusion is well documented.Objective: Functional...
Inhaled formulations using extrafine particles of long-acting β2-agonists and corticosteroids were developed to optimize asthma treatment. Findings that these combinations reach treat smaller airways more effectively are predominantly based on general non-specific outcomes with little information regional characteristics.This study aims assess long-term effects beclomethasone/formoterol small asthmatic patients novel functional imaging methods.Twenty-four stable subdivided into three groups...
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification of chronic obstructive pulmonary disease (COPD) does not always match with other clinical descriptors such as exacerbation frequency and quality life, indicating that forced expiratory volume in 1 s (FEV ) is a perfect descriptor the disease. aim this study was to find out whether changes airway geometry after inhalation most commonly used therapy severe COPD can more adequately be described an image-based...
Background: Salbutamol and ipratropium bromide improve lung function in patients with chronic obstructive pulmonary disease (COPD). However, their bronchodilating effect has not yet been compared the central distal airways. Functional imaging using computational fluid dynamics offers possibility of making such a comparison. The objective this study was to assess effects salbutamol on geometry dynamics-based resistance Methods: Five Global Initiative for Chronic Obstructive Lung Disease Stage...
Introduction: Noninvasive ventilation (NIV) is a well-established treatment for acute-on-chronic respiratory failure in hypercapnic COPD patients. Less known about the effects of long-term with NIV patients and factors that may predict response terms improved oxygenation lowered CO 2 retention. Methods: In this study, we randomized 15 to routine pharmacological (n = 5, age 66 [standard deviation ± 6] years, FEV 1 30.5 [±5.1] %pred, PaO 65 [±6] mmHg, PaCO 52.4 [±6.0] mmHg) or (using Synchrony...
Background Pseudomonas aeruginosa (Pa) infection is an important contributor to the progression of cystic fibrosis (CF) lung disease. The cornerstone treatment for Pa use inhaled antibiotics. However, there substantial disease heterogeneity within and between patients that likely impacts deposition patterns Therefore, this may result in airways below minimal inhibitory concentration agent. Very little known about antibiotic concentrations small airways, particular effect structural...