A5065527235- Foot and Ankle Surgery
- Lower Extremity Biomechanics and Pathologies
- Tendon Structure and Treatment
- Bone Tumor Diagnosis and Treatments
- Oral and Maxillofacial Pathology
- Cerebral Palsy and Movement Disorders
- Diabetic Foot Ulcer Assessment and Management
- Sarcoma Diagnosis and Treatment
- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Scoliosis diagnosis and treatment
- Hip disorders and treatments
- Bone health and treatments
- Neurogenetic and Muscular Disorders Research
- Inflammatory mediators and NSAID effects
- Cytokine Signaling Pathways and Interactions
- Eicosanoids and Hypertension Pharmacology
- Bone health and osteoporosis research
- Nail Diseases and Treatments
- Connective tissue disorders research
- Balance, Gait, and Falls Prevention
- Muscle activation and electromyography studies
- Viral Infectious Diseases and Gene Expression in Insects
- Musculoskeletal synovial abnormalities and treatments
Maastricht University
2017-2024
Maastricht University Medical Centre
2012-2023
Isala
2022
University Medical Center Groningen
2022
University Medical Center
2004-2022
Orthopedic One
2014
Amsterdam UMC Location Vrije Universiteit Amsterdam
2004
University Hospital and Clinics
2004
University of Alabama at Birmingham
2004
Vrije Universiteit Amsterdam
2004
Abstract Purpose: The clinical course of osteosarcoma (OS) demands the development new therapeutic options. Conditionally replicative adenoviruses (CRAds) represent promising agents for treatment solid tumors, because CRAds have an intrinsic replication capacity that allows in situ amplification and extensive tumor infection through lateral spread. CRAd AdΔ24 has been developed to replicate selectively cells with a defective retinoblastoma (Rb) pathway. Because genetic alterations Rb pathway...
Arthrodesis of the first metatarsophalangeal (MTP1) joint is an intervention often used in patients with severe MTP1 osteoarthritis and relieves pain approximately 80% these patients. The kinematic effects compensatory mechanism foot for restoring a more normal gait pattern after this are unknown. aim study was to clarify mechanism, which it hypothesized that hindfoot forefoot would be responsible compensation arthrodesis joint.Gait properties were evaluated 10 feet 8 compared 21 12 healthy...
Background: Several operative interventions are available to alleviate pain in hallux rigidus, and the optimal technique is still a topic of debate among surgeons. Three these arthrodesis, cheilectomy, Keller’s arthroplasty. Currently, it unclear which intervention yields best long-term result. The aim this study was assess performed terms patient-reported outcome, scores, disease recurrence at follow-up. Methods: These data follow-up initial published 2006. In original study, 73 patients (n...
Purpose Dysplasia epiphysealis hemimelica (DEH) is a rare developmental disorder resulting in epiphyseal overgrowth. Based on histological appearance, it often described as an osteochondroma or osteochondroma-like lesion, although clinical differences exist between DEH and osteochondromas. The aim of this study was to test whether osteochondromas are histologically identical diseases. Methods Tissue samples two age- gender-matched cases with hereditary multiple exostoses were compared....
Background. The purpose of this study is to evaluate functional and radiological outcomes subtalar arthroereisis in the treatment symptomatic pediatric flexible flatfeet. Methods. A total 16 patients (26 feet) were treated with a Kalix II as motion blocker between 2009 2014. Calcaneal pitch (CP) Meary’s angle (MA) measured on radiographs preoperatively, directly postoperatively, at follow-up 47 ± 17 (range 19-79) months. Patient satisfaction surveys used assess outcome patient satisfaction....
Background: Worldwide a wide variation exists in duration of Pavlik harness treatment for infants up to 6 months with stable developmental dysplasia the hip (DDH). The purpose this study was evaluate whether shortening time first routine follow-up ultrasound after initiation would reduce and influenced radiologic outcome at 1 year age. Furthermore, predictors higher acetabular index (AI) age were investigated. Methods: A retrospective conducted DDH (Graf IIb IIc) diagnosed treated between...
Objective Despite the general awareness that cyclo-oxygenase-2 (COX-2) is crucial for endochondral ossification, role of COX-2 in skeletal development largely unknown. We hypothesized inhibition or genetic loss leads to impaired growth plate and consequently postnatal long bones. Design Skeletally immature (5 weeks old) B6;129S-Ptgs2 tm1Jed /J wildtype mice were treated 10 with celecoxib (daily oral administration mg/kg) placebo compared homozygous knockout ( n = 12 per group). Results...
Previous research showed that hallux rigidus (HR) affects foot and ankle kinematics during gait. It is unclear if HR lower limb as well. Does affect kinematics, so, gait deviation correlated with patient-reported outcome? This was a retrospective case-control study, including 15 patients healthy controls who underwent three-dimensional analysis by using the Plug-in Gait body model. The Profile Score (GPS), index score describing composed out of nine Variable Scores (GVS), intersegmental...
Multiple hereditary exostoses is an autosomal dominant inherited disease causing exostoses: growth on the bones of children.The mainly caused by mutated exostosin (EXT)-1 or EXT-2 genes.These mutations yield non-functional EXT-gene products.Lack functional proteins cause a defect in heparan sulphate synthesis and therefore proteoglycan modification cell signalling.It assumed that subset chondrocytes form exostoses, through differentiation process which only partially understood.The place...
Compensatory motion of foot joints in hallux rigidus (HR) are not fully known. This study aimed to clarify the kinematic compensation within and detect whether this affects plantar pressure distribution.Gait characteristics were assessed 16 patients (16 feet) with HR compared 15 healthy controls (30 three-dimensional gait analysis by using multi-segment Oxford Foot Model, measuring spatio-temporal parameters, joint kinematics pressure.HR subjects showed less flexion during midstance...
Abstract Restriction of physical growth and development is a known problem in patients with juvenile idiopathic arthritis (JIA). However, the effect medical treatment for JIA on skeletal affected children has not been properly investigated. We, therefore, hypothesize that naproxen methotrexate (MTX) affect endochondral ossification will lead to reduced development. Treatment ATDC5 cells, an vitro model ossification, or MTX resulted increased chondrogenic but decreased hypertrophic...
Ribosome biogenesis is integrated with many cellular processes including proliferation, differentiation and oncogenic events. Chondrogenic proliferation require a high translational capacity to facilitate cartilaginous extracellular matrix production. We here investigated the expression dynamics of factors involved in ribosome during vitro chondrogenic determined whether protein translation adapts different phases differentiation.SnoRNA ATDC5 was analyzed by RNA sequencing samples acquired...