A5048484408- Influenza Virus Research Studies
- Respiratory viral infections research
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Receptor Mechanisms and Signaling
- T-cell and B-cell Immunology
- Bacterial Infections and Vaccines
- Immune Response and Inflammation
- Protein Structure and Dynamics
Icahn School of Medicine at Mount Sinai
2017-2020
Abstract Background Influenza causes a substantial burden worldwide, and current seasonal influenza vaccine has suboptimal effectiveness. To develop better, more broadly protective vaccines, thorough understanding is needed of how antibodies that target the virus surface antigens, hemagglutinin (HA) (including head stalk regions) neuraminidase (NA), impact illness transmission. Methods We used case-ascertained, community-based study household transmission set in Managua, Nicaragua. Using...
Significance The development of a universal influenza vaccine is major public health need globally, and identifying the optimal formulation will be an important first step for developing such vaccine. Here we show that two-dose immunization humans with inactivated, AS03-adjuvanted H5N1 avian virus engaged both preexisting memory naive B cell compartments. Importantly, recruited cells after were directed against conserved epitopes within H5 HA stem region while responses second mostly...
Abstract The high variation of the influenza virus hemagglutinin (HA), particularly its immunodominant head epitopes, makes it necessary to reformulate seasonal vaccines every year. Novel that redirect immune response toward conserved epitopes HA stalk domain should afford broad and durable protection. Sequential immunization with chimeric HAs (cHAs) express same distinct exotic heads has been shown elicit levels broadly cross-reactive Abs. In current mouse studies, we tested this strategy...
Human influenza virus infections with avian subtype H7N9 viruses are a major public health concern and have encouraged the development of effective H7 prepandemic vaccines. In this study, baseline postvaccination serum samples individuals aged 18 years older who received recombinant hemagglutinin vaccine without an oil-in-water emulsion (SE) adjuvant were analyzed using panel serological assays. While only small proportion seroconverted to as measured by conventional hemagglutination...
Licensed influenza virus vaccines target the head domain of hemagglutinin (HA) glycoprotein which undergoes constant antigenic drift. The highly conserved HA stalk is an attractive to increase immunologic breadth required for universal vaccines. We tested hypothesis that immunization with a pandemic vaccine boosts pre-existing anti-stalk antibodies. used chimeric cH6/1, full length H2 and H18 antigens in ELISA measure antibodies recipients participating clinical trials A/H1N1, A/H5N1 A/H9N2...