A5013622538- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Cardiac Health and Mental Health
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- Pharmacological Effects and Toxicity Studies
- Cardiomyopathy and Myosin Studies
- Neurological and metabolic disorders
- Obstructive Sleep Apnea Research
- Long-Term Effects of COVID-19
- Neuroscience of respiration and sleep
- Nutrition and Health in Aging
- Congenital Heart Disease Studies
- Diabetes Treatment and Management
- Metabolism and Genetic Disorders
- Blood Pressure and Hypertension Studies
- Cardiac Ischemia and Reperfusion
- Hepatitis C virus research
- Stress Responses and Cortisol
- Nitric Oxide and Endothelin Effects
- Cardiac Arrest and Resuscitation
- Osteoarthritis Treatment and Mechanisms
- Lipoproteins and Cardiovascular Health
University Hospital Leipzig
2023
Carl von Ossietzky Universität Oldenburg
2013-2022
Krankenhaus Nordwest
2022
Klinikum Oldenburg
2013-2015
Philipps University of Marburg
2010-2012
University of Göttingen
2002-2011
Medical University of Graz
2010
Universitätsmedizin Göttingen
2005
University of Bonn
1997-2003
Heart failure with normal ejection fraction (HFnEF) is an important clinical entity that remains incompletely understood. The novel biomarker growth differentiation factor 15 (GDF-15) elevated in systolic heart (HFrEF) and predictive of adverse outcome. We investigated the relevance GDF-15 plasma levels HFnEF.A subgroup patients from ongoing DIAST-CHF observational trial, a history chronic (CHF) or positive Framingham criteria at presentation, was selected. Patients were classified as having...
We tested the hypothesis that, in heart failure with normal ejection fraction (HFNEF), diastolic dysfunction is accentuated at increasing rates, and this contributes to impaired frequency-dependent augmentation of cardiac output. In 17 patients HFNEF (median age 69 years, 13 female) seven age-matched control patients, systolic function was analysed by pressure–volume loops baseline rate during atrial pacing 100 120 min−1. At baseline, relaxation prolonged end-diastolic left ventricular...
We investigated whether obstructive sleep apnoea (OSA) independently affects diastolic function in a primary care cohort of patients with cardiovascular risk factors. 378 study participants factors for dysfunction were prospectively included and polygraphy was performed all patients. Diastolic assessed by comprehensive echocardiography including tissue Doppler. Sleep classified according to apnoea/hypopnoea index (AHI) as none (AHI <5 events·h −1 ), mild ≤5 <15 ) or moderate-to-severe...
Atrial fibrillation (AF) is one of the most frequent causes stroke. Several randomized trials have shown that prolonged monitoring increases detection AF, but effect on reducing recurrent cardioembolism, ie, ischemic stroke and systemic embolism, remains unknown. We aim to evaluate whether a risk-adapted, intensified heart rhythm with consequent guideline conform treatment, which implies initiation oral anticoagulation (OAC), leads reduction cardioembolism.Find-AF 2 randomized, controlled,...
Background — Application of pyruvate was shown to improve contractile function in isolated animal myocardium and hemodynamics patients with congestive heart failure. We assessed the influence on systolic diastolic myocardial its subcellular mode action from end-stage failing human hearts. Methods Results In muscle strip preparations, concentration-dependent effects developed force (n=6), aequorin light emission reflecting intracellular Ca 2+ transients rapid cooling contractures sarcoplasmic...
Objective: Stretch induces functional and trophic effects in mammalian myocardium via various signal transduction pathways. We tested stretch on immediate slow force response (SFR) rabbit myocardium. Methods: Experiments were performed isolated right ventricular muscles from adult hearts (37 °C, 1 Hz stimulation rate, bicarbonate-buffer). Muscles rapidly stretched 88% of optimal length (L88) to near (L98) for analysis. The resulting increases twitch (first phase SFR, respectively) assessed...
Summary: Purpose: Treatment with carbamazepine (CBZ) is known to affect apolipoprotein B–containing lipoprotein concentrations in serum. However, little about the effects of anticonvulsant drugs (AEDs) on lipoprotein(a) [Lp(a)], although Lp(a) has been characterized as independent cardiovascular risk factor. We investigated prospectively effect CBZ concentration normolipidemic healthy adults. Methods: Twenty male volunteers were included study. levels determined before and 69 ± 19 days after...
Stretch induces immediate and delayed inotropic effects in mammalian myocardium via distinct mechanosensitive pathways, but these are poorly characterized human cardiac muscle. We tested the of stretch on force response failing myocardium. Experiments were performed muscle strips from 52 hearts (37 degrees C, 1 Hz, bicarbonate buffer). Muscles stretched 88% optimal length to 98% length. The resulting (ie, slow [SFR]) increases twitch assessed without after blockade sarcoplasmic reticulum...
Journal Article Stretch-dependent modulation of [Na+]i, [Ca2+]i, and pHi in rabbit myocardium–a mechanism for the slow force response Get access Claus Luers, Luers Department Cardiology Pneumology, University Goettingen, Robert-Koch-Str. 40, 37075 Germany Search other works by this author on: Oxford Academic PubMed Google Scholar Florian Fialka, Fialka Andreas Elgner, Elgner Danan Zhu, Zhu Jens Kockskämper, Kockskämper Dirk von Lewinski, Lewinski Burkert Pieske * *Corresponding author. Tel.:...
The diagnostic value of natriuretic peptides in asymptomatic patients at risk for diastolic or systolic HF is controversial. We tested (1) the prevalence preclinical LV dysfunction an at-risk cohort; (2) accuracy alone combination with clinical parameters predicting left ventricular dysfunction.542 primary care (mean age 63 +/- 11 years, 42% female) without prediagnosed HF, but factors dysfunction, underwent thorough cardiological workup, including echocardiography and analysis peptides.23...
It is currently unknown whether elevated cytokine levels in depression are confined to any specific subgroup of depressive patients. In this study, medical out-patients presenting with cardiovascular risk factors (N = 356) were assessed for both cognitive–affective and physical symptoms using the Hospital Anxiety Depression Scale (HADS) Maastricht questionnaire (MQ), respectively. study participants assigned highest (≥21) lowest (≤5) quartile MQ score, serum cytokines measured. We found...
Treatment with carbamazepine (CBZ) affects cholesterol concentrations, but little is known about the precise nature and underlying mechanisms of changes in lipoprotein metabolism. We investigated prospectively effects CBZ on lipid metabolism normolipemic adults. In 21 healthy males, noncholesterol sterol concentrations were measured before during treatment for 70 ± 18 days. Thirteen subjects underwent kinetic studies apolipoprotein-B (ApoB) use endogenous stable isotope labeling. Lipoprotein...
Left ventricular filling pressure (LVFP) is a marker for diastolic dysfunction and heart failure (HF) with preserved ejection fraction (pEF). The interaction between arterial stiffness (AS) elevated LVFP has not been sufficiently investigated. In 257 patients left (mean age: 66 years, 53% female, mean fraction: 61%) at least one cardiovascular risk factor (eg, hypertension diabetes) the development of HF or previous diagnosis HF, was estimated in accordance recommendations American Society...
Background We investigated the modifying role and prognostic importance of diastolic dysfunction ( DD ) in patients with heart failure systolic SD ). Hypothesis The echocardiographic evaluation function provides further information. Methods From German Competence Network Heart Failure, 1046 reduced left ventricular ejection fraction LVEF ; <50%) were echocardiographically studied followed for a median 5 years. was subdivided into nonsevere 36%–49%) severe ≤35%); (E/E′ <15) ≥15)....
Abstract Background The clinical phenotype dilated cardiomyopathy is assumed to be the endstage of a multifactorial aetiopathogenetic pathophysiology which includes not satisfactorily defined group patients with inflammatory cardiomyopathy. Methods Within German Competence Network Heart Failure heart failure due viral/inflammatory ( DCM i/v) and nonviral/noninflammatory ) aetiology were enrolled. After 1 year 237 (180 male/57 female) re‐examined including complete work‐up. association...
The hepatic metabolism of lidocaine (1 mg/kg intravenously) to its metabolite monoethylglycinexylidide (MEG-X) is the basis standard MEG-X test. To reduce lidocaine-induced side effects, we evaluated formation after 0.5 and 1 intravenously in subjects with normal (n = 5) severely impaired liver function 7) (study I). From this study, a low-dose test (MEG- X concentration 30 minutes 50 mg [MEG- 30min ] normalized results) was developed. Sensory effects from low dose were compared...
To assess heart failure therapies in diabetic patients with preserved as compared to impaired systolic ventricular function.3304 from 9 different studies were included (mean age 63 ± 14 years); out of these, 711 subjects had left ejection fraction (≥ 50%) and 994 the whole cohort suffered diabetes.The majority (>90%) reduced (SHF) diabetes treated an ACE inhibitor (ACEi) or angiotensin receptor blocker (ARB) beta-blockers. By contrast, (HFNEF) less likely receive these substance classes (p <...