A5100452740- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Analytical Chemistry and Chromatography
- Analytical chemistry methods development
- Mass Spectrometry Techniques and Applications
- Pharmacological Effects and Assays
- Antimicrobial Resistance in Staphylococcus
- Drug Transport and Resistance Mechanisms
- Pharmaceutical and Antibiotic Environmental Impacts
- Hormonal and reproductive studies
- Microbial Natural Products and Biosynthesis
- Pneumonia and Respiratory Infections
- Electrochemical sensors and biosensors
- Electrochemical Analysis and Applications
- Chromatography in Natural Products
- Natural Compound Pharmacology Studies
- Pesticide Residue Analysis and Safety
- Traditional Chinese Medicine Analysis
- Neurological and metabolic disorders
- Botulinum Toxin and Related Neurological Disorders
- Carbon and Quantum Dots Applications
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Advanced biosensing and bioanalysis techniques
- Plant-Microbe Interactions and Immunity
- Plant Disease Resistance and Genetics
Northeast Agricultural University
2020-2025
Zhejiang University of Technology
2025
Huzhou University
2025
Pharmaceutical Biotechnology (Czechia)
2025
Second People’s Hospital of Yibin
2024
Wuhan Polytechnic University
2023
Shanghai Customs College
2019-2023
Henan University of Science and Technology
2019-2022
Mayo Clinic Health System
2022
Chung Shan Medical University
2022
Bran is the major byproduct in wheat processing with low development and utilization rates. Polyphenols are a bioactive component bran beneficial to human health. In this study, polyphenols were extracted by four methods analyzed ultra-performance liquid chromatography-tandem mass spectrometry (UPLC‒MS). Among methods, alkaline hydrolysis method had highest polyphenol yield (4.38 ± 0.18 mg GAE/g DW). The antioxidant activity results revealed that obtained extraction showed lowest...
The pharmacokinetics and tissue distribution of enrofloxacin were determined in Yellow River carp (Cyprinus carpio haematopterus) reared at 20°C after single oral administration 10 mg·kg-1 body weight (BW). Plasma, bile, different samples, including liver, kidney, gill, gut, skin-muscle, collected predetermined times points. An HPLC method was developed to simultaneously determine the concentrations its metabolite, ciprofloxacin. However, ciprofloxacin only detectable some liver samples with...
Dementia has been gaining attention in aging societies and is estimated to affect 50 million adults globally 2020, 12% of the US population may develop a thyroid disorder their lifetime. There have limited studies investigating correlation between dementia Asian population. Our large nationwide population-based case-control study used Taiwanese National Health Insurance Research Database. A total 7,843 with newly diagnosed without history or neurodegenerative disease 2006 2013 were...
Gummy stem blight (GSB), which is caused by Stagonosporopsis cucurbitacearum, threatens pumpkin yields and agriculture. Effective, safe antifungal agents are urgently needed. In this study, fermentation broth supernatant of Streptomyces sp. NEAU-T55 demonstrated considerable activity against S. cucurbitacearum. Activity-guided isolation identified 2 new 14 known compounds, with (+)-methyl nonactate (10) determined as the main active ingredient. This compound exhibited strong (EC50 = 0.12 μg...
This review will focus specifically on the state of art novel sample pretreatment methods which have been combined with ICP-MS based hyphenated techniques for elemental speciation in biological samples.
This study aimed to determine whether the challenge from Escherichia coli (E. coli) lipopolysaccharide (LPS) affects pharmacokinetics of danofloxacin in broilers. Twenty 1-day-old Arbor Acres (AA) broilers were equally and randomly divided into 2 groups. When chickens 23, 25, 27, 29 days old, E. LPS (1 mL; 0.5 mg/kg body weight [BW]) sterile saline mL) intraperitoneally injected two After last injection, was given all by gavage at dose 5 BW. Then serum plasma samples each time point...
A novel method by hyphenating chip-based array ion-imprinted monolithic capillary microextraction with ICP-MS was proposed for the online analysis of trace Gd in biological samples.
Background:Simultaneous bilateral basal ganglia hemorrhage is an infrequent occurrence in medical literature.The etiology of intracerebral remains elusive, contrast to that unilateral hypertensive hemorrhage, resulting lack consensus among scholars.Importantly, patients with uremia and cerebral especially large hematoma volumes, exhibit a markedly elevated mortality rate.Patients can benefit from implementation positive efficacious therapeutic approaches. Case Report:We present clinical case...
Abstract The widespread abuse of anabolic androgenic steroids by healthy people leads to the risk major mood disorders and heart failure; thus, determination is vital. In this study, 17 in dietary supplements external drugs were identified, their concentration was determined. For purpose, polyaniline‐coated magnetic nanoparticles prepared then subjected solid‐phase extraction combined with high‐performance liquid chromatography–tandem mass spectrometry. experimental parameters studied...
This study aimed to determine the population pharmacokinetics of danofloxacin in healthy Yellow River carp (Cyprinus carpio Haematopterus) after single oral administration at 10 mg/kg body weight (BW). A sparse sampling was applied this and plasma samples were randomly collected from tail veins six 0.25, 0.5, 1, 2, 4, 6, 8, 12, 16, 24, 36, 48, 72, 96, 120 144 h administration. maximum four each carp. Then concentrations determined through an HPLC method. Danofloxacin could be quantified up...
Enrofloxacin (ENR) has been approved for the treatment of infections in aquaculture, but it may cause tissue residue. This research aimed to develop and validate a water temperature related PBPK model, including both ENR ciprofloxacin (CIP), rainbow trout, predict further their residue concentrations withdrawal periods at different temperatures. With published data, flow-limited model CIP sub-models was developed tissues plasma/serum after intravenous, oral, or immersion administration. A...
BACKGROUND:Linezolid (LZD) has been reported to combat several intractable infectious diseases, including multidrug-resistant infections and tuberculosis. Although quite a number of adverse effects LZD therapy have abundantly described so far, associated lactic acidosis thrombocytopenia rarely studied. We patient dying with complications. To the best our knowledge, this is first report focusing on complications in treating patients deadly abnormalities hemogram. CASE REPORT:A 50-year-old...
β-Blockers and β2-agonists are commonly prescribed for therapeutic treatments also administered to livestock, leading their presence in both environmental biological samples. Hence, the development of sensitive, rapid, reliable analytical methods determination β-blockers samples is important. In this study, MIL-101(Cr)-NH2 &GO-coated SiO2 /Fe3 O4 magnetic particles were prepared as sorbents solid-phase extraction then combined with high-performance liquid chromatography-tandem mass...
Cancer is a serious threat to human health. With the increasing resistance known drugs, it still urgent find new drugs or pro-drugs with anti-tumor effects. Natural products produced by microorganisms have played an important role in history of drug discovery, particularly anticancer and anti-infective areas. The plant rhizosphere ecosystem rich resource for discovery actinomycetes potential applications pharmaceutical science, especially Streptomyces. We screened Streptomyces-like strains...
Abstract The pharmacokinetic properties of amoxicillin (AMX) and clavulanic acid (CLV) were studied in healthy cats following single intravenous oral dosage 10 mg/kg AMX 2.5 CLV. drug concentrations plasma determined by a high‐performance liquid chromatographic – tandem mass spectrometry (LC‐MS‐MS) method validated for canine further subjected to noncompartmental analysis. After injection, no significant difference ( p > 0.05) was found the volume distribution these two compounds. In...