A5066476789- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular and exercise physiology
- Non-Invasive Vital Sign Monitoring
- Hemodynamic Monitoring and Therapy
- Nitric Oxide and Endothelin Effects
- Cardiovascular Function and Risk Factors
- Neurological Disease Mechanisms and Treatments
University of Delaware
2019-2025
Increased arterial wave reflections can increase left ventricular wasted pressure effort (WPE) and cardiovascular disease risk. Naturally menstruating women experience fluctuations in sex hormones with known cardioprotective effects. We sought to determine whether hormonal alter hemodynamics or reflections, thereby WPE, contribute differences. hypothesized that premenopausal would have favorable reflection changes reduced WPE during high- vs. low-hormone cycle phases compared men. tested 13...
Early return and increased magnitude of wave reflection augments pulsatile load, wastes left ventricular effort, is associated with cardiovascular events. Acute handgrip (HG) exercise increases surrogate measures such as augmentation index. However, index does not allow distinguishing between timing versus affected by factors other than per se. Wave separation analysis decomposes central pressure into relative contributions forward (Pf) backward (Pb) amplitudes to calculate (RM = Pb/Pf)...
Aging increases arterial stiffness and wave reflections that augment left ventricular wasted pressure effort (WPE). A single bout of exercise may be effective at acutely reducing WPE via reductions in reflections. In young adults (YA) acute aerobic decreases, whereas handgrip increases, Whether mitigates or exacerbates reflection healthy aging warrants further examination. The purpose this study was to determine if there are age-related differences during exercise. When compared with...
Following aerobic exercise, sustained vasodilation and concomitant reductions in total peripheral resistance (TPR) result a reduction blood pressure that is maintained for two or more hours. However, the time course postexercise changes reflected wave amplitude other indices of pulsatile load on left ventricle have not been thoroughly described. Therefore, we tested hypothesis reduced beyond an hour after cycling at 60% V̇o
Introduction: Aberrant vascular function contributes to the substantially high cardiovascular burden of chronic kidney disease (CKD). Mitochondrial derived oxidative stress is a potential therapeutic target ameliorate CKD related dysfunction. Hypothesis: We hypothesized that mitochondrial targeted antioxidant (MitoQ) would improve in Stage 3-5 patients without overt disease. Methods: In this controlled, double-blind trial, 18 (Mean±SEM: Age, 62±3 years; eGFR, 45±3 ml•min•1.73 2 ) were...
We have previously shown that wasted pressure effort (WPE), the needed to overcome effect of wave reflections during systole, is reduced following an acute bout aerobic exercise in young adults. Research has women a more favorable hemodynamic response after compared men. These differences may be due cardioprotective effects female sex hormones premenopausal are lost menopause. It not known if WPE differentially affected by men and whether age influences exercise. PURPOSE: This retrospective...
Increased wave reflection augments pulsatile load, wastes left ventricular effort, and is associated with cardiovascular events. Acute handgrip (HG) exercise increases central blood pressure surrogate measure of reflection, augmentation index. However, measures do not provide a comprehensive assessment load ventricular‐arterial interactions. Wave separation analysis can determine the relative contributions forward (Pf) backward (Pb) amplitudes magnitude (RM=Pb/Pf) as well timing apparent...
In the hours following moderate intensity aerobic exercise (AE), persistent dilation of arterial circulation supplying previously exercised muscle decreases total peripheral resistance (TPR) and contributes to post‐exercise hypotension. addition effect vasodilation on TPR, diameter tone vessels also influences central blood pressures via changes in amplitude forward (Pf) backward (Pb) pulse waves, as well apparent wave reflection return timing (i.e. reflected transit time, RWTT). Prior...
A significant proportion of patients with non-dialysis chronic kidney disease (CKD) present mild-to-moderate deficits in the cognitive domains executive function and episodic memory. Excess blood flow pulsatility is damaging to microvasculature high-flow, low-resistance organs like brain may contribute prevalent among CKD patients. We tested hypothesis that moderate-to-severe have excess along their carotid cerebral vasculature associated recruited 10 (age=68±8 yrs; estimated glomerular...