A5020610266- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Cardiovascular Function and Risk Factors
- Atmospheric Ozone and Climate
- Cardiac electrophysiology and arrhythmias
- Exercise and Physiological Responses
- Cardiac Ischemia and Reperfusion
- Nitric Oxide and Endothelin Effects
- Medicinal Plants and Neuroprotection
- Cardiovascular and exercise physiology
- Natural product bioactivities and synthesis
- Extracellular vesicles in disease
- Cardiomyopathy and Myosin Studies
- COVID-19 Clinical Research Studies
- Phytochemicals and Medicinal Plants
- Menopause: Health Impacts and Treatments
- Food Science and Nutritional Studies
- Pregnancy and preeclampsia studies
- Tryptophan and brain disorders
- Natural Antidiabetic Agents Studies
- Redox biology and oxidative stress
- Atmospheric and Environmental Gas Dynamics
- Heme Oxygenase-1 and Carbon Monoxide
- Long-Term Effects of COVID-19
- Synthesis of β-Lactam Compounds
University of Nebraska Medical Center
2023-2025
Jamia Hamdard
2018-2024
Institute of Medical Sciences
2018-2024
Indira Gandhi National Open University
2016-2019
Cognitive impairment (CGI) is common in patients with cardiovascular diseases, contributing to morbidity and mortality, especially among people over the age of 64. Cardiogenic dementia has been suggested characterize suffering from cognitive decline after heart disease. Clinical experimental evidence further suggest that 35%-65% myocardial ischemia are affected by CGI which include memory global deficits. Although increasing suggests neurological disorders, such as stroke underlying a...
Context. In about 2000, the south pole of Triton experienced an extreme summer solstice that occurs every ∼650 years, when subsolar latitude reached 50°S. Bracketing this epoch, a few occultations probed atmosphere in 1989, 1995, 1997, 2008, and 2017. A recent ground-based stellar occultation observed on 6 October 2022 provides new measurement atmospheric pressure Triton. This is presented here. Aims. The goal to constrain volatile transport models (VTMs) atmosphere. basically vapor...
Icariin, a major component of Epimedium species, was evaluated using isoproterenol (ISO)-induced cardiotoxicity in Wistar rats. Rats were treated with icariin at the doses 1, 5, and 10 mg kg −1 orally for 15 days. Afterward, rats administered ISO (85 , subcutaneous) on 14th 15th day to produce cardiac injury. Sildenafil (0.7 intraperitoneal) used as positive reference compare effects icariin. ISO-treated showed significant changes hemodynamic parameters. Elevated levels troponin T, nitric...
Abstract Sterile inflammation (SI) is an essential process in response to snakebite and injury. The venom induced pathophysiological sterile results into many harmful deleterious effects that ultimately leads death. available treatment for antiserum which does not provide enough protection against venom-induced changes like haemorrhage, necrosis, nephrotoxicity often develop hypersensitive reactions. In order overcome these hindrances, scientists around the globe are searching alternative...
The present study aimed to evaluate the therapeutic and prophylactic potential of Coriandrum sativum extract in isoproterenol-induced heart failure (HF) Wistar rats. Two weeks after isoproterenol administration, rats developed severe impairment left ventricular functions, reduced baroreflex sensitivity, significant alteration hemodynamic parameters lipid profile. HF also exhibited enhanced peroxidation increased expression endothelin receptors (ETA ETB). Therapeutic treatment with C....
Heart failure (HF) is a leading cause of hospitalization across the world and known to ill-health heavy economic losses. In present study, rat model isoproterenol (ISO, 85 mg/kg subcutaneously for two subsequent days) induced HF was developed. ISO induces by its direct effect, that is, rise in left ventricular end-diastolic pressure (mechanical) indirectly altering baroreflex (neural), electrocardiography (electrical), development oxidative stress hyperlipidemia (chemical). Fenofibrate,...
This study aims to explore the role of estrogen in providing cardioprotective benefits premenopausal women, examining how hormonal differences between sexes influence prevalence cardiovascular diseases (CVDs) women. Eighteen female Wistar rats were equally distributed into three treatment groups. Animals Group I (sham-operated) and II (ovariectomized [OVX]) received oral saline solution at a dose 2 mL/kg. III (OVX+E2) E2 µg/mL/kg after ovariectomy. Hemodynamic parameters baroreflex...
Context - Around the year 2000, Triton's south pole experienced an extreme summer solstice that occurs every about 650 years, when subsolar latitude reached 50{\deg}. Bracketing this epoch, a few occultations probed atmosphere in 1989, 1995, 1997, 2008 and 2017. A recent ground-based stellar occultation observed on 6 October 2022 provides new measurement of atmospheric pressure which is presented here. Aims- The goal to constrain Volatile Transport Models (VTMs) basically vapor equilibrium...
Introduction: Cardiovascular disease (CVD) is a leading cause of death worldwide. Excessive reactive oxygen species (ROS) in the vasculature has been suggested as one major players CVD. In addition, CVDs such peripheral arterial (PAD) have elevated oxidative stress (OS) damage, stemming from an imbalance between antioxidants and ROS both skeletal muscles. Although vascular disease, most common symptom PAD leg pain due to muscle ischemia OS damage. The Nuclear factor erythroid 2-related 2...
Introduction: Hypertension is a serious global public health issue. It complex disease with multiple factors contributing to its pathophysiology. One of these oxidative stress, which results from an imbalance between the production and elimination reactive oxygen species (ROS). Studies have shown that increased ROS in endothelial cells (EC) impairs vasodilatory capacity blood vessels contributes pressure elevation. However, modulation setting hypertension still not completely understood. To...
Abstract Heart failure is a syndrome, caused due to structural and functional cardiac abnormalities, characterized by changes in the hemodynamic neurohumoral mechanisms. It becoming major health burden worldwide. More effective therapies are desperately needed. Coriandrum sativum ( C. ), traditional spice crop has been known possess many biological medicinal properties. The present study was designed investigate cardioprotective efficacy of rat model isoproterenol induced heart failure....
Introduction: Excessive oxidant stress has been shown to mediate a variety of cardiovascular pathological conditions, including hypertension. The level reactive oxygen species (ROS) in tissues is regulated by the balance between production ROS and ability scavenge superoxide hydrogen peroxide myriad antioxidant enzymes small molecules. One most important regulators activity ubiquitous transcription factor Nuclear erythroid 2-related 2 (Nrf2). Nrf2 binds response elements multiple genes...
Introduction: Excessive oxidant stress has been shown to damage cardiac tissue and result in impaired function. Animals with chronic heart failure (CHF) exhibit lower levels of antioxidant enzymes many tissues including the heart, brain, skeletal muscle (SkM). Nrf2 is a ubiquitous master transcription factor that regulates proteins during enhanced oxidative stress. Earlier studies from this laboratory showed exercise training was cardioprotective following ischemia reperfusion injury mice....
Introduction: Endothelial dysfunction is considered a key contributor to vascular pathologies. It well-accepted that excessive reactive oxygen species and oxidative damage likely contribute endothelial dysfunction. The transcription factor nuclear erythroid 2-related 2 (Nrf2) the master regulator of endogenous antioxidant responses. Therefore, Nrf2 may be potential therapeutic target protect against However, roles cell (EC)-specific on function are not known. major objective this study was...
ABSTRACT Background: The information on the pathophysiology of infection in high-risk contacts SARS-CoV-2 is limited. Aims: aim present study was to assess various factors and their elucidation protection SARS- CoV-2 contacts. Settings Design: Cross-sectional descriptive clinical study. Materials Methods: A total 136 subjects were recruited including 100 36 control subjects. Out subjects, 44 found positive for RNA. Further, absolute blood counts T-cells (CD3+), T-helper cells (CD4+),...