A5103105029- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Vector-Borne Animal Diseases
- Viral Infections and Vectors
- Genomic variations and chromosomal abnormalities
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Diet, Metabolism, and Disease
- Prenatal Screening and Diagnostics
- Peroxisome Proliferator-Activated Receptors
- Rabies epidemiology and control
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Alcohol Consumption and Health Effects
- Genetic Syndromes and Imprinting
- Hematopoietic Stem Cell Transplantation
- Diabetes and associated disorders
- Toxin Mechanisms and Immunotoxins
- Immune Response and Inflammation
- Congenital heart defects research
- T-cell and B-cell Immunology
- Cancer Mechanisms and Therapy
- T-cell and Retrovirus Studies
- Insect symbiosis and bacterial influences
Jeonbuk National University
2013-2019
Asan Medical Center
2014
University of Ulsan
2014
Ulsan College
2014
Toll-like receptor 7 (TLR7) signaling predominantly regulates production of type I interferons (IFNs), which has been suggested in clinical studies to be antifibrotic. However, the mechanistic role TLR7-type IFN axis liver fibrosis not elucidated. In present study, was induced wild-type (WT), TLR7-deficient, and IFN-α/β receptor-1 (IFNAR1)-deficient mice TLR7-mediated assessed cells isolated from these mice. TLR7-deficient IFNAR1-deficient were more susceptible than WT mice, indicating that...
Abstract Recently, a possible link between toll-like receptor 7 (TLR7) and liver disease was suggested, although it limited to fibrosis. Based on this report, we investigated whether TLR7 has pivotal role in non-alcoholic fatty (NAFLD). The signaling pathway, which is activated by imiquimod (TLR7 ligand) naturally, induced autophagy released insulin-like growth factor 1 (IGF-1) into medium from hepatocytes. Lipid accumulation unsaturated acid (UFA; arachidonic acid:oleic = 1:1) hepatocytes,...
Aim: Nicotine exerts a number of physiological effects. The purpose this study was to determine the effects nicotine on thioacetamide (TAA)-induced liver fibrosis in mice.Materials and methods: For vivo experiments, hepatic induced by TAA (0.25 g/kg, i.p.) three times week for 6 weeks. Mice treated groups were administered daily with distilled water (50 or 100 μg/mL) via gastrogavage throughout experimental period. vitro HepG2 (human cancer cell line) LX-2 stellate used oxidative stress...
Akabane virus (AKAV), an arthropod-transmitted bunyavirus, is a major cause of congenital abnormalities and encephalomyelitis in ruminants. In 2010, there was outbreak Korea fifteen AKAV strains, including AKAV-7, were isolated from cows. To identify the neuropathogenicity we performed experimental infection Six-month-old female Korean Holstein dairy cattle inoculated with AKAV-7 by various routes, intracerebral (IC), intrasubarachnoid space (IS), subcutaneous (SC) intravenous (IV); separate...
Hematopoiesis is a complex process requiring multiple regulators for hematopoietic stem/progenitor cells (HSPC) and differentiation to multi-lineage blood cells. TC1(C8orf4) implicated in cancers, hematological malignancies inflammatory activation. Here, we report that Tc1 regulates hematopoiesis mice. Myeloid lymphoid are increased markedly peripheral of Tc1–deleted mice compared wild type controls. Red small-sized but number. The bone marrow Tc1−/− normocellular histologically. However,...
Side stream cigarette smoke (SSCS) is known to be as harmful and hazardous human health active smoking. In this study, we investigated the relationship between exposure SSCS its stimulatory subacute effects on progression of non-alcoholic steatohepatitis (NASH). A methionine choline-deficient plus high fat (MCDHF) diet was administered C57BL/6 mice for 6 weeks. During first three weeks MCDHF feeding, each group exposed (0, 20, 40 μg/L) or fresh air 2 hrs per day 5 days week. Additional...
Conventional cytogenetic analysis using G-band karyotyping has been the method of choice for prenatal diagnosis, accurately detecting chromosomal abnormalities larger than 5 Mb. However, is inefficient submicroscopic deletions and duplications that are associated with malformations mental retardation. This study evaluated results multiplex ligation-dependent probe amplification (MLPA) P245 assay used diagnosis in cases unusual ultrasonographic findings or specifically where parents wanted to...
We describe a B-cell lymphoma of submandibular lymph node with metastasis to the lung and facial subcutaneous tissues in water deer ( Hydropotes inermis ). Neoplastic cells contained pleomorphic lymphocytes that were positive for CD79a, consistent lymphoma. PCR bovine leukemia virus was negative.
We describe coinfection with Hepatozoon sp. and canine distemper virus (CDV) in a yellow-throated marten ( Martes flavigula koreana). found cysts muscular tissue viral inclusion bodies the brain. sp., CDV was confirmed blood brain, respectively, by PCR.
Purpose: To evaluate the additive value of prenatal chromosomal microarray analysis (CMA) in assessing increased nuchal translucency (NT) (≥3.5 mm) with normal karyotype and possibility detecting clinically significant genomic imbalance, based on specific indications.Materials Methods: Invasive samples from 494 pregnancies NT ≥3.5 mm, obtained Research Center Fertility & Genetics Hamchoon Women's Clinic between January 2019 February 2020, were included this study CMA was performed addition...