A5093132896- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Pneumonia and Respiratory Infections
- Immunodeficiency and Autoimmune Disorders
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Peptidase Inhibition and Analysis
- Escherichia coli research studies
- Proteoglycans and glycosaminoglycans research
- Hemoglobin structure and function
- Hemoglobinopathies and Related Disorders
- Neonatal Health and Biochemistry
- Chronic Obstructive Pulmonary Disease (COPD) Research
Humboldt-Universität zu Berlin
2024
Charité - Universitätsmedizin Berlin
2023-2024
Freie Universität Berlin
2024
The pulmonary epithelial glycocalyx is rich in glycosaminoglycans such as hyaluronan and heparan sulfate. Despite their presence, the importance of these bacterial lung infections remains elusive. To address this, we intranasally inoculated mice with
The pulmonary epithelial glycocalyx is rich in glycosaminoglycans such as hyaluronan and heparan sulfate. Despite their presence, the precise role of these bacterial lung infections remains elusive. To address this, we intranasally inoculated mice with Streptococcus pneumoniae presence or absence enzymes targeting sulfate, followed by characterization subsequent disease pathology, inflammation, barrier dysfunction. Enzymatic degradation sulfate exacerbated pneumonia mice, evidenced increased...
The pulmonary epithelial glycocalyx is rich in glycosaminoglycans such as hyaluronan and heparan sulfate. Despite their presence, the precise role of these bacterial lung infections remains elusive. To address this, we intranasally inoculated mice with Streptococcus pneumoniae presence or absence enzymes targeting sulfate, followed by characterization subsequent disease pathology, inflammation, barrier dysfunction. Enzymatic degradation sulfate exacerbated pneumonia mice, evidenced increased...
α-1,2-Fucosylierung, ein spezifisches Zuckermotiv am terminalen Ende von N- und O-Glykanen, ist für verschiedene Prozesse in Säugetieren, einschließlich der Synthese Blutgruppenantigenen, dem Mucin-Glykan Capping oder auch bei Interaktion zwischen Wirt Pathogen, großer Bedeutung (Schneider et al. 2017, Li 2018). Die Rolle fucosylierten Glykanen bakteriellen Pathogenese im Kontext respiratorischer Infektionen jedoch weitgehend unerforscht. Diese Arbeit zielt darauf ab, zu entschlüsseln, wie...
Community-acquired pneumonia remains a major contributor towards global communicable disease-mediated morbidity and mortality despite the availability of protective vaccines effective antibiotics. The glycocalyx is dense layer rich in glycoproteins, glycosaminoglycans proteoglycans, which also harbors variety sugars including fucose. Despite their abundance lungs, contribution fucosylated glycans bacterial pathogenesis largely unexplored. In this study we aim to understand role...