A5011928612- Sulfur-Based Synthesis Techniques
- Catalytic C–H Functionalization Methods
- Synthesis and biological activity
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Reactions
- Synthesis of heterocyclic compounds
- Multicomponent Synthesis of Heterocycles
- Synthesis of Organic Compounds
- Quinazolinone synthesis and applications
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Biochemical and Molecular Research
- Cyclopropane Reaction Mechanisms
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Organoselenium and organotellurium chemistry
- Fluorine in Organic Chemistry
- Catalytic Cross-Coupling Reactions
- Cancer therapeutics and mechanisms
- Neonatal Health and Biochemistry
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Reactivity of Heterocycles
- Synthesis and Biological Evaluation
- Chemical Synthesis and Analysis
The Charutar Vidya Mandal (CVM) University
2021-2022
Manubhai Patel Dental College and Hospital
2017-2021
Sardar Patel University
2016-2017
A novel series of compounds incorporating a fluoro substituted pyrazole nucleus clubbed with 1,3,4-oxadiazole scaffolds (<bold>7a–p</bold>) was synthesized in good yields (79–89%).
A combinatorial library of polyhydroquinoline scaffolds is successfully attempted by multicomponent cyclocondensation reaction.
Abstract A novel strategy for N‐chlorosuccinimide mediated direct sulfenylation of 1‐aryl pyrazolones using aryl thiols has been developed at room temperature. The protocol was found to be simple, efficient and transition metal‐free afford the target products in good excellent yields without further purification. prepared compounds were characterised by 1 H NMR, 13 C NMR IR spectroscopy. skeleton one synthesized well confirmed X‐ray single crystal diffraction (XRD) analysis as ORTEP diagram.
An efficient and simple method is reported for the cyanation on arylboronic acid using various simple/indole thiocyanates a new IL-PdCl4 catalyst. The cascade process involves coupling reaction without any additive to give wide range of cyanide derivatives. Cyanation acids underwent smoothly affording corresponding arylnitriles in good high yields.
Abstract A facile synthetic protocol has been established for the N ‐chlorosuccinimide (NCS) promoted direct C−H thiocyanation of 1‐aryl‐5‐pyrazolones via in situ‐ generated electrophilic thiocyanating agent at room temperature. The current features easy performance, mild conditions and short reaction time using readily available starting materials. DFT studies suggested that ionic process is likely to be involved this transformation yielding targeted product with most stable enaminone form...
Abstract A facile synthetic strategy has been established for the microwave‐assisted construction of two C−C bond via regioselective double arylation imidazo[1,2‐ a ]pyridines with 1,2‐diiodobenzene by employing Pd(OAc) 2 as catalyst. The current protocol exhibited simple, efficient and ligands free synthesis 1‐phenylbenzo[ ]imidazo[5,1,2‐ cd ]indolizine derivatives in good to excellent yields. This Pd‐catalyzed dual provided valuable tool discovery fluorescent materials.
A novel silica gel functionalized-SO3H as a heterogeneous catalyst was prepared and characterized by FT-IR, XRD, TGA elemental analysis. It has been studied for microwave-assisted solvent-free Pechmann condensation. The result revealed that 20% w/w bonded 3-mercapto propyl diethylene diamine N-sulfamic acid (SMPDDSA) found to be effective. 4-methyl coumarin derivatives were the only product obtained in good excellent yield (75–94%). present protocol accomplishes reaction much lesser time...
The construction of C-S bond is considered as an important protocol in organic transformations. An innovative strategy for CuI-catalyzed sulfenylation 1-aryl-3-alkyl-1H-pyrazol-5(4H)-ones have been developed using elemental sulfur the source. This procedure provides a useful and direct approach assembly wide range structurally diverse 4-sulfenyl pyrazolones with moderate to excellent yields from simple readily available starting materials. method might be potentially applicable large scale...
Abstract In this contribution, we provide a comprehensive overview on the C−H activation/functionalization reactions of 1‐aryl‐5‐pyrazolones, in particular, 1‐aryl‐3‐methyl‐1H‐pyrazol‐5(4H)‐ones (edaravones) and their N ‐methyl analogues i. e ., antipyrines covering literature since 2013 (the year first report). This review summarizes recent progress functionalization 1‐aryl‐5‐pyrazolones including edaravone antipyrine derivatives under transition‐metal‐catalyzed/free conditions discusses...
Abstract A simple and efficient strategy for N‐chlorosuccinimide mediated regioselective C−H sulfenylation halogenation of 4 H ‐pyrido[1,2‐ a ]pyrimidin‐4‐ones has been established at room temperature using aryl thiols phenyliodine(III) diacetate (PIDA) respectively. This methodology tolerated broad variety functional groups to obtain structurally diverse sulfenyl halogenated ‐pyrido[1,2‐a]pyrimidin‐4‐one derivatives under mild conditions. It delivered range products which can serve as the...
The synthesis of a novel tolylthiopyrazol bearing methyl group has been achieved by transition metal free N-chlorosuccinimide mediated direct sulfenylation 1-aryl pyrazolones at room temperature. product obtained was characterized spectroscopic techniques and finally confirmed X-ray diffraction studies. compound 1-(2-chlorophenyl)-3-methyl-4-(p-tolylthio)-1H-pyrazol-5-ol (m.f. C17H15N2OSCl) crystallizes in monoclinic crystal class space P21/c with cell parameters = 9.6479(5) Å, b 15.1233(8)...