A5041030981- CAR-T cell therapy research
- Nausea and vomiting management
- Colorectal Cancer Treatments and Studies
- Anesthesia and Pain Management
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Anesthesia and Sedative Agents
- Prostate Cancer Treatment and Research
- Economic and Financial Impacts of Cancer
- Pharmacological Effects and Toxicity Studies
- Pharmaceutical Practices and Patient Outcomes
- Renal cell carcinoma treatment
- Cutaneous lymphoproliferative disorders research
- Safe Handling of Antineoplastic Drugs
- Statistical Methods in Clinical Trials
- PARP inhibition in cancer therapy
- Medication Adherence and Compliance
- COVID-19 and healthcare impacts
- Pain Management and Opioid Use
- BRCA gene mutations in cancer
- Reflective Practices in Education
- Cancer Treatment and Pharmacology
- Viral-associated cancers and disorders
- Chemotherapy-related skin toxicity
- Pharmacogenetics and Drug Metabolism
University of Waterloo
2017-2024
Sunnybrook Health Science Centre
2017-2023
Health Sciences Centre
2019-2023
University of Toronto
2018-2019
Creative Commons
2018
In a global, phase III, open-label, noninferiority trial (REFLECT), lenvatinib demonstrated to sorafenib in overall survival and statistically significant increase progression-free patients with unresectable hepatocellular carcinoma (HCC). Recently, became the first agent more than 10 years receive approval as first-line therapy for HCC, along previously approved sorafenib. The objective of this study was determine comparative cost-effectiveness HCC.A state-transition model HCC developed...
Abstract Background Treatment options for patients with platinum-refractory, recurrent, metastatic head and neck squamous cell carcinoma (r/m HNSCC) are limited prognosis is poor. The recent CheckMate 141 clinical trial demonstrated that nivolumab, an anti-programmed death protein 1 monoclonal antibody, was efficacious in extending the median overall survival (OS) this patient population compared standard therapies. We conducted a cost-effectiveness analysis to determine whether nivolumab...
The development of chimeric antigen receptor (CAR) T cells has transformed oncology treatment, with the potential to cure certain cancers. Although shown be effective in selected populations and studies, CAR T-cell technology requires considerable health care resources, which may lead additional wait times access this type treatment future. objective our study was estimate impact increasing on therapy effectiveness compared standard chemotherapy for patients relapsed/refractory diffuse large...
Objective. To evaluate attitudes toward peer review of teaching and its impact on practices perceptions. Methods. The University Waterloo School Pharmacy implemented a peer-review process for program in 2015. Those reviewed were invited to complete an electronic survey that captured their teaching, review, changes practices, participate semi-structured follow-up interviews more in-depth discussion these issues. Results. Twenty-six (76%) instructors completed the survey. Instructors agreed...
Abstract: The world of oncology treatment is rapidly changing, and with the investigation into utilization molecular signaling pathways for cancer treatment, many new targeted small-molecule oral agents have been introduced as therapies, more drugs appearing every year. These agents, while generally considered less toxic overall than traditional chemotherapy, are not without adverse effects. authors undertook an extensive literature search to determine incidence, severity, management...
Aim: To investigate the factors associated with treatment selection and overall survival for first-line EGFR-tyrosine kinase inhibitors (EGFR-TKIs) therapy among patients non-small-cell lung cancer. Materials & methods: We conducted a retrospective cohort study of linked administrative health databases in Ontario, Canada. Results: A total 1011 received an EGFR-TKI as therapy. Treatment these treatments were affected by age, sex, geographical residency, comorbidities different sites...
A qualitative interview-based study summarized valuable perspectives from stakeholders that highlight some of the unique challenges to implementing a highly-personalized and expensive-to-deliver chimeric antigen receptor (CAR) T-cell therapy in Canada.
Background Chimeric antigen receptor (CAR) T-cell therapy is a novel cell for treating non-Hodgkin lymphoma. The development of CAR has transformed oncology treatment by offering potential cure. However, due to the high cost these therapies, and large number eligible patients, decision makers are faced with difficult funding decisions. Our objective was assess cost-effectiveness tisagenlecleucel adults relapsed/refractory diffuse B-cell lymphoma in Canada using updated survival data from...
Canadian clinical pharmacy key performance indicators (cpKPIs) have been developed for inpatient hospital practice but are not established ambulatory oncology. This study represents the first step in developing cpKPIs oncology.To describe current landscape of services oncology Canada and to identify perspectives related development implementation this setting.In national cross-sectional study, a web-based questionnaire was distributed pharmacists working settings. Potential participants who...
Cardiovascular complications can occur in oncology patients secondary to certain cancer therapies. Pharmacists are involved the care of who at risk or experiencing cardiotoxicity related their therapy. Our study aimed understand how pharmacists Canada these and explore experiences, perceptions, challenges.Canadian currently receiving treatments were invited participate a 30-min telephone interview using an guide. A combination inductive deductive reasoning was applied two coders...
Objective A prospective open-label randomized controlled trial to assess the role of a picture-based medication calendar on adherence antiemetic regimens for adult patients receiving chemotherapy and effect other taking behaviors as well patient satisfaction with tool. Methods Participants were randomly assigned 1:1 routine care or without calendar. Results Adherence, stratified by education (university postgraduate, p = 0.09; grade school, high school college 0.32), was non-significantly...
Introduction The coronavirus of 2019 pandemic has necessitated vast and rapid changes in the way oncology pharmacy services are delivered around world. Methods/aims An international survey pharmacists technicians was conducted via International Society Oncology Pharmacy Practitioners collaborating global organisations to determine impact that had on service delivery, practitioners practice. Results received 862 responses from 40 different countries September October 2020. majority...
Abstract Mantle cell lymphoma is a rare subtype of B-cell which carries with it poor prognosis and typically refractory to treatment. Autologous stem transplant (ASCT) has been shown improve survival, but not considered curative. There currently no specific preferred regimen treatment according current guidelines for patients who fail ASCT. We undertook systematic scoping review examine the existing literature in this setting. A total 3045 records were screened, yielding 40 full-text...
Monitor INR 3 days after initiation and then once weekly for 4 weeks, as becomes stable the interval may increased slowly.Figure 1.0.Anticoagulation management atrial fibrillation in a patient receiving abiraterone + prednisone.Abbreviations: CAD; coronary artery disease.ASA; acetylsalicylic acid.CHADS 2 ; congestive heart failure, hypertension, age >65, diabetes, prior stroke or transient attack.CrCl; creatinine clearance