A5001404768- Tendon Structure and Treatment
- Muscle metabolism and nutrition
- Urban Transport and Accessibility
- Skin Diseases and Diabetes
- Myofascial pain diagnosis and treatment
- Older Adults Driving Studies
- Transportation and Mobility Innovations
- Hormonal and reproductive studies
Michigan Medicine
2025
University of Michigan
2025
Michigan State University
2021
SUMMARY Tendinopathy is a tendon disorder that caused by the failure to self-repair and has many pathological characteristics such as disorganized ECM decreased cell viability. We have identified possible target combat these changes, AMPK, an energy stress sensor was shown maintain intracellular homeostasis. Through bulk RNA-sequencing of healthy tendinopathic tendons from humans we novel finding downregulation AMPK signaling in samples which suggests plays role Our studies utilizing...
Purpose/aim Some youth seek puberty suppression to prolong decision-making prior starting hormone therapy help align their physical sex characteristics with gender identity. During peripubertal growth, connective tissues such as tendon rapidly adapt applied mechanical loads (e.g. exercise) yet if and how adaptation is influenced by gender-affirming during growth remains unknown. The goal of this study was understand pubertal followed testosterone influences the structural functional...