Atrial fibrillation (AF), an inflammatory process involving arrhythmia, is associated with severe morbidity and mortality commonly seen in patients diabetes mellitus (DM). The effect of metformin, the most used medication for DM, on AF has not been investigated. primary aim this study was to examine whether metformin prevented occurrence type 2 DM by analyzing a nationwide, population-based dynamic cohort. Additionally, we investigated tachycardia-induced myolysis oxidative stress atrial...

It is unclear whether the non–vitamin K antagonist oral anticoagulant agents rivaroxaban and dabigatran are superior to warfarin for efficacy safety outcomes in Asians with nonvalvular atrial fibrillation (NVAF). The aim of this study was compare risk thromboembolic events, bleeding, mortality associated versus NVAF. A nationwide retrospective cohort conducted consecutive patients NVAF taking (n = 3,916), 5,921), or 5,251) using data collected from Taiwan National Health Insurance Research...

Whether non-vitamin K antagonist oral anticoagulants (NOACs) are superior to warfarin among Asians with nonvalvular atrial fibrillation remains unclear.In this nationwide retrospective cohort study collected from Taiwan National Health Insurance Research Database, there were 5843, 20 079, 27 777, and 19 375 patients taking apixaban, dabigatran, rivaroxaban warfarin, respectively, June 1, 2012 December 31, 2016. Propensity-score weighting was used balance covariates across groups. Patients...

Background Liver cirrhotic patients with nonvalvular atrial fibrillation have been excluded from randomized clinical studies regarding oral anticoagulants for stroke prevention. Whether non–vitamin K antagonist ( NOAC s) are superior to warfarin these remains unclear. Methods and Results This nationwide retrospective cohort study, data collected the Taiwan National Health Insurance Research Database, enrolled 2428 liver taking apixaban (n=171), dabigatran (n=535), rivaroxaban (n=732), or...

Whether dabigatran is associated with different risks of cardiovascular, bleeding events, and mortality from warfarin in Asian patients nonvalvular atrial fibrillation remains unclear.We used the Taiwan National Health Insurance Research Database to obtain 9940 9913 taking warfarin, respectively, June 1, 2012, December 31, 2013, as dynamic cohort. Inverse probability treatment weighting using propensity scores was balance covariates across 2 study groups. Patients were followed up until...

Whether dabigatran is associated with a lower risk of acute kidney injury (AKI) in patients nonvalvular atrial fibrillation (NVAF) remains unknown. The authors compared the AKI Asians NVAF who were prescribed versus warfarin. analyzed enrolled Taiwan nationwide retrospective cohort study from June 1, 2012, to December 31, 2013. Dabigatran and warfarin taken by 7,702 7,885 without history chronic disease (CKD) 2,256 2,089 CKD, respectively. A propensity-score weighted method was used balance...

Infective endocarditis (IE) is an uncommon but potentially devastating disease. Recently published data have revealed a significant increase in the incidence of IE following restriction on indications for antibiotic prophylaxis as recommended by revised guidelines. This study aims to reexamine basic assumption behind rationale that dental procedures risk IE. Using Longitudinal Health Insurance Database Taiwan, we retrospectively analyzed total 739 patients hospitalized between 1999 and 2012....

Abstract Background The aim of the present study was to identify long-term major adverse cardiovascular events (MACE) in adult congenital heart disease (ConHD) patients Taiwan. Methods From National Health Insurance Research Database (1997-2010), (≥18 years) with ConHD were identified and compared non-ConHD control patients. primary end point incidence MACE. Cox proportional hazards models used compute hazard ratios as estimates for multivariate adjusted relative risks or without adjusting...

Whether dipeptidyl peptidase-4 inhibitor (DPP4i) is associated with a lower risk of new-onset atrial fibrillation (AF) in patients diabetes remains unclear. This study aimed to evaluate the AF use DPP4i among longitudinal cohort diabetes. Over 3-year period, 480,000 were analyzed utilizing Taiwan's National Health Insurance Research Database and 90,880 taking metformin as first-line therapy enrolled. Patients further divided into two groups: (1) users: those (2) non-DPP4i prescribed other...

The aim of the present study was to identify long-term major adverse cardiovascular events (MACE) in treated periodontitis patients Taiwan.From National Health Insurance Research Database (2001-2010), adult (≥ 18 years) with were identified. Comparison made between mild form and severe after propensity score matching. primary end point incidence MACE.A total 32,504 identified 2001 2010. After matching, 27,146 preserved for comparison, including 13,573 periodontitis. During follow-up, 728...

Background and Purpose: Data on clinical outcomes for nonvitamin K antagonist oral anticoagulant (NOACs) warfarin in patients with atrial fibrillation cancer are limited, active were excluded from randomized trials. We investigated the effectiveness safety NOACs versus among cancer. Methods: In this nationwide retrospective cohort study Taiwan National Health Insurance Research Database, we identified a total of 6274 1681 consecutive taking June 1, 2012, to December 31, 2017, respectively....

Recent studies have proven that initial renal dysfunction and worsening function during hospitalization can predict the clinical outcome of patients with acute myocardial infarction (AMI). There is limited study regarding kidney injury (AKI) by RIFLE classification (Risk failure, Injury to kidney, Failure function, Loss End-stage failure) assess AMI survivors.During a mean follow-up period 635.3 ± 204.9 days, 2-year mortality rate was 10.6% in 613 who survived discharge. Adjusted Cox...

Abstract Background Evidence of adverse clinical outcomes for non-vitamin K antagonist oral anticoagulant (NOACs) and warfarin in patients with atrial fibrillation (AF) diabetes mellitus are limited. We investigated the effectiveness, safety, major limb events NOACs versus among diabetic AF patients. Methods In this nationwide retrospective cohort study collected from Taiwan National Health Insurance Research Database, we identified a total 20,967 5812 consecutive taking June 1, 2012, to...

Abstract Background Whether sodium glucose co-transporter 2 inhibitors (SGLT2i) are associated with a lower risk of cardiovascular as well adverse limb events in patients type-2 diabetes mellitus (T2DM) and concomitant peripheral artery disease (PAD) is unclear. We aimed to evaluate the events, death use SGLT2i compared dipeptidyl peptidase-4 (DPP4i) among longitudinal national cohort T2DM. Methods In this nationwide retrospective study based on Taiwan National Health Insurance Research...

Background Myocardial infarction (MI) is a medical emergency resulting from coronary artery occlusion. Patients with acute MI often experience disturbed sleep and circadian rhythm. Most previous studies assessed the premorbid rhythm of patients their correlations cardiovascular disease. However, little known about post-MI impacts on prognosis. The use actigraphy different algorithms to evaluate after has potential for predicting outcomes preventing future disease progression. Objective We...

Aims The ratio of transmitral early filling velocity (E) to diastolic tissue (E′) is a key function parameter. strain rate (E′sr) has been proposed as substitute for E′ in the E/E′ better estimation left ventricular (LV) pressure. This study aims assess predictive value combined E/E′sr and global longitudinal (GLS) prognosis systolic heart failure (SHF). Methods results We retrospectively analysed 330 SHF patients with an LV ejection fraction (LVEF) ≤ 40%. Study end points were defined...

The present study aimed to assess the association between severity of chronic periodontitis and risk gastrointestinal (GI) cancers by investigating whether severe (CP), rather than mild CP, correlates with an increased total or individual GI cancers. Adults (≥18 years) CP were identified from a random sample 2 million insured patients in National Health Insurance Research Database (2001–2010). After propensity score matching, 25,485 individuals, each included for comparison. primary endpoint...

Patients with myocardial infarction (MI) can have disturbed sleep, but little is known about the efficacy of light therapy on sleep and prognosis patients MI. We conducted a randomized controlled study to investigate its efficacy. This preliminary included 34 They were into blue white groups during their stay in intensive care unit. 17 age gender matched healthy controls also enrolled. Actigraphy was used evaluate objective since enrollment. Delirium scales screen delirium. Lab work-up...

This retrospective claims database analysis compared two strategies of hypertension treatment in outpatient, emergency, and inpatient departments: a fixed‐dose combination ( FDC ) amlodipine/valsartan vs free combinations angiotensin receptor blockers ARB s) calcium channel CCB + group). After mean follow‐up 15.2 months, the group had significantly lower total healthcare costs US $1844 $2158; P <.001) hospitalization rates (14.57% 18.43%; <.001), higher proportion days covered (80.35%...