We describe how reactivity can be controlled in the solid state using molecules and self-assembled metal−organic complexes as templates. Being able to control bears relevance synthetic chemistry materials science. The former offers a promise synthesize that may impossible realize from liquid phase while also taking advantage of benefits conducting highly stereocontrolled reactions solvent-free environment (i.e., green chemistry). latter provides an opportunity modify bulk physical properties...

Cryptands, carcerands, polyoxometalates, and molecular capsules are cagelike hosts that complex guests through encapsulation. Following the discovery of a nanometer scale supramolecular shell-like spheroid, these other were structurally classified. Their frameworks may be catalogued according to principles solid geometry. This has led identification have not yet been synthesized or discovered (such as cuboctahedron shown; X=O, S) should lead design additional container assemblies.

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSupramolecular Control of Reactivity in the Solid State Using Linear Molecular Templates†Leonard R. MacGillivray, Jennifer L. Reid, and John A. RipmeesterView Author Information Steacie Institute for Sciences National Research Council Canada Ottawa, Ontario, Canada, K1A 0R6 Cite this: J. Am. Chem. Soc. 2000, 122, 32, 7817–7818Publication Date (Web):July 29, 2000Publication History Received10 April 2000Published online29 July inissue 1 August...

The synthesis and single crystal X-ray structures are reported of two interwoven cationic frameworks that based upon tetrahedral trigonal CuI ions; the resulting architectures diamondoid, [CuI(bipy)2(PF6)]∞(bipy = 4,4′-bipyridyl)1, honeycomb, [CuI)2(pz)3(SiF6)]∞(pz pyrazine)2, respectively.

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTDesign and Self-Assembly of Cavity-Containing Rectangular GridsLeonard R. MacGillivray, Ryan H. Groeneman, Jerry L. AtwoodView Author Information Department Chemistry University MissouriColumbia Columbia, Missouri 65211 Cite this: J. Am. Chem. Soc. 1998, 120, 11, 2676–2677Publication Date (Web):March 5, 1998Publication History Received15 October 1997Revised29 January 1998Published online5 March inissue 1...

Steps in supramolecular chemistry: Molecules the form of linear templates have been used to preorganize polyenes solid state through hydrogen-bonding interactions. The can then undergo [2+2] photocycloaddition reactions produce [3]- and [5]ladderanes gram quantities 100 % yield. (The picture shows obtained [5]ladderane.) An [n]ladderane1 is a molecule that consists n edge-sharing cyclobutane rings (where n≥2) define molecular equivalent macroscopic ladder.1 Ladderanes are considered...

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTCoordination-Driven Self-Assembly Directs a Single-Crystal-to-Single-Crystal Transformation that Exhibits Photocontrolled FluorescenceGiannis S. Papaefstathiou, Zhenming Zhong, Lei Geng, and Leonard R. MacGillivrayView Author Information Department of Chemistry Optical Science Technology Center, University Iowa, Iowa City, 52242 Cite this: J. Am. Chem. Soc. 2004, 126, 30, 9158–9159Publication Date (Web):July 9, 2004Publication History...

Reactions in crystals: Interactions between AgI ions are used to preorganize olefins for a regiocontrolled single-crystal-to-single-crystal (SCSC) [2+2] photodimerization that results quantitative conversion of finite dinuclear complex into one-dimensional coordination network (see scheme).

We report a method to enforce face-to-face stacking of the aromatic rings organic semiconductor molecules in solid state that employs bifunctional hydrogen-bond donors, form cocrystal formers, align building blocks.

This Perspective describes how chemists can control intermolecular [2 + 2] photodimerizations in the solid state using small molecules as linear templates. The templates assemble olefins into positions for reaction via hydrogen-bond-driven self-assembly. We attach functional groups to that complement hydrogen bond donor and acceptor of resulting cyclobutane-based products form stereospecifically, quantitatively, gram amounts. are used direct formation a [2.2]paracyclophane ladderanes....

Cocrystals are modular multicomponent solids with exceptional utility in synthetic chemistry and materials science. A variety of methods exist for the preparation cocrystals, yet, some promising cocrystal phases have proven to be intractable targets. We describe a strategy synthesis pharmaceutically relevant (caffeine)·(benzoic acid) (1), which persistently failed form using broad range established techniques. State-of-the-art crystal structure prediction were employed assess possible...

Chemical mechanics: Hydrogen-bond-driven self-assembly and mechanochemistry are used to facilitate supramolecular catalysis in the solid state. Mortar-and-pestle grinding proves be an efficient means achieve co-crystal formation turnover using a physical mixture composed of olefin catalytic amounts ditopic template (see scheme).

A ditopic halogen-bond acceptor organizes a diiodooctafluorostilbene for [2+2] photodimerization reaction to take place between two stilbene molecules in the solid state. The resultant cyclobutane product is functionalized with halogen atoms and undergoes self-assembly form channel-type host-guest compound that exhibits very rare of self-inclusion.

Ag(I) is used to form a π-stacked metal–organic solid that exhibits remarkably high electrical conductivity. The undergoes single-crystal-to-single-crystal [2+2] photodimerization generate 1D coordination polymer with over 40% higher complex represents the first example of an increase in conductivity resulting from photodimerization. Density states calculations show contribution ions valence band photodimerized solid, supporting

The DEAD (Asp-Glu-Ala-Asp)-box helicase 3 X-linked (DDX3X) protein participates in many aspects of mRNA metabolism and stress granule (SG) formation. DDX3X has also been associated with signal transduction cell cycle regulation that are important maintaining cellular homeostasis. Malfunctions have implicated multiple cancers, including brain cancer, leukemia, prostate head neck cancer. Recently, literature reported SG-associated cancer drug resistance, which correlates a negative disease...

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTPreparation and Reactivity of Nanocrystalline Cocrystals Formed via SonocrystallizationDejan-Krešimir Bučar Leonard R. MacGillivrayView Author Information Department Chemistry, University Iowa, Iowa City, 52242-1294 Cite this: J. Am. Chem. Soc. 2007, 129, 1, 32–33Publication Date (Web):December 15, 2006Publication History Received4 October 2006Published online15 December inissue 1 January...

The reaction between transition metal halides MX2 (where M = Co(II) and Ni(II)) in an aqueous solution containing disodium terephthalate along with pyridine-based ligands gives rise to one-dimensional coordination polymers. Both [M(terephthalate)(4-picoline)2(H2O)2]·2(4-picoline) (1) [M(terephthalate)(pyridine)2(H2O)2]·2(pyridine)·2(H2O) (2) have been isolated. These frameworks exhibit hydrogen bond donors running the backbone of each polymer, which inclusion chemistry framework pyridine...

Nach den Prinzipien der Geometrie Körper können Kryptanden, Carceranden, Polyoxometallate und molekulare Kapseln strukturell klassifiziert werden. Diese käfigartigen Wirtverbindungen komplexieren die Gäste durch Einkapseln. Entdeckung eines supramolekularen, Sphäroids im Nanometermaßstab wurden Gerüste dieses anderer Wirte katalogisiert. Dies bildete Grundlage für das Auffinden neuer Wirte, bislang noch nicht synthetisiert oder entdeckt worden sind (wie Bild gezeigte Kuboktaeder; X = O, S),...

Abstract The purpose of this review is to address fundamentals and applications single-crystal-to-single-crystal (SCSC) reactions, based on the [2 + 2] photodimerization. An overview SCSC photodimerizations, which comprise single- multi-component solids, will be given. We reveal that materials exhibit reactivity can considered have been achieved via either discovery or design. suggest if generally achieved, could provide new avenues control bulk physical properties solid-state materials.

Caffeine, a pharmaceutical model compound, generally forms cocrystals with carboxylic acids that involve an O−H···N hydrogen bond between the acid group of and caffeine imidazole moiety. Such solids are typically based on single heterosynthon. To examine facility introducing additional supramolecular heterosynthons to caffeine-carboxylic-acid cocrystal system, structural isomers aromatic (i.e., hydroxy- dihydroxybenzoic acids) hydrogen-bonding functional groups hydroxy group) were screened...