A5074975992- Cholesterol and Lipid Metabolism
- Cardiac Ischemia and Reperfusion
- Pericarditis and Cardiac Tamponade
- Bone Tissue Engineering Materials
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Tissue Engineering and Regenerative Medicine
- Bone health and osteoporosis research
- Mast cells and histamine
- Nigella sativa pharmacological applications
- Sperm and Testicular Function
- Drug-Induced Hepatotoxicity and Protection
- Cardiac Structural Anomalies and Repair
- Myasthenia Gravis and Thymoma
- Tumors and Oncological Cases
- Essential Oils and Antimicrobial Activity
- Anesthesia and Sedative Agents
- Vitamin C and Antioxidants Research
- Pharmacological Receptor Mechanisms and Effects
- Cardiac tumors and thrombi
- Genomics, phytochemicals, and oxidative stress
- Dental Implant Techniques and Outcomes
- Immunotherapy and Immune Responses
- Anesthesia and Neurotoxicity Research
- Liver Disease Diagnosis and Treatment
Cairo University
2012-2024
National Research Centre
2018
Myocardial infarction (MI) is a critical condition that can happen with high doses or rapid termination of beta blockers therapy. The study aimed to evaluate the potential anti-toxic value DAP against isoproterenol (ISO) - induced MI. Twenty-eight male Wistar rats were used for study. rodents assigned four groups ( n = 7) and treatments given 12 days as follows; Group 1 (control): administrated normal saline, 2 (DAP control): (10 mg/kg/day IP), 3 (ISO group): ISO (100 mg/kg, IP on 11th 12th...
Testicular torsion is an emergency, mainly in newborn and adolescent males, resulting testicular ischemia. The current study aimed to evaluate the effect of Idebenone (IDE) on torsion/detorsion (T/D) juvenile rats. Thirty-two rats were randomized into: (1) sham group: received operations with no other interventions; (2) IDE idebenone (100 mg/kg, i. p) without T/D; (3) T/D underwent for 2 h detorsion 4 h; (4) IDE+ 1 before T/D. malondialdehyde (MDA), total nitrite/nitrate (NOx), antioxidant...
BackgroundUlcerative colitis (UC) is a chronic inflammatory disease of large intestine. Overproduction free radicals, lowered antioxidant capacity and abnormal apoptosis are involved in pathogenesis. Nebivolol, β blocker with vasodilatory, antioxidant, anti-inflammatory effects, can play future role therapies for UC.Aim the studyThe purpose this study was to evaluate protective effect nebivolol against acetic acid (AA)-induced UC rats.MethodsMale wistar rats were pre-treated orally 5...
Abstract Aim Olive oil was used in the past as a remedy for many diseases due to its unlimited benefits health. This study carried out assess analgesic, anti‐pyretic and anti‐inflammatory activities of extra virgin olive ( EVOO ) at dose 8 mL /kg body weight compare it with ibuprofen IBU an individual drug therapy combination two different doses (therapeutic 100 mg/kg low 40 mg/kg), on animal models albino mice. Method A total 132 adult healthy male Swiss mice were this study. The analgesic...
BackgroundUlcerative colitis (UC) is a chronic inflammatory disease of large intestine. Overproduction free radicals, lowered antioxidant capacity and abnormal apoptosis are involved in pathogenesis. Nebivolol, β blocker with vasodilatory, antioxidant, anti-inflammatory effects, can play future role therapies for UC.Aim the studyThe purpose this study was to evaluate protective effect nebivolol against acetic acid (AA)-induced UC rats.MethodsMale wistar rats were pre-treated orally 5...
Ulcerative colitis is a serious premalignant condition with confusing multifactorial pathogenesis. It should warrant all attention by researchers, for exploration of new prophylactic or therapeutic drugs targeting its pathophysiology. The current study was conducted to the possible role tadalafil and potential actions in ulcerative rat model, induced acetic acid. Forty eight male Wistar albino rats were classified into 6 groups: control group, acid (AA)-ulcerated AA-ulcerated + (1...
Alendronate is a drug of choice in the treatment postmenopausal osteoporosis. Acid suppressive drugs are recently used combination with alendronate to protect against stomach ulceration and oesophagitis occurring as serious problems patients under this treatment. To study effect pantoprazole ranitidine on anti-resorptive rat model 64 female Wister albino rats were included (8 rats/group). Treated groups Ovariectomized bilaterally induce Rats treated orally (3 mg/kg/day), (20 combined or for...
Abstract Background People of Mediterranean descent are primarily affected by the autoinflammatory genetic condition known as familial fever (FMF). The disease is resistant to colchicine therapy in 10–20% patients. Numerous recent animal studies showed promising results extra virgin olive oil (EVOO) control inflammation. objective this study was assess effectiveness combining EVOO with treatment colchicine-resistant (CRFMF) Results Both frequency episodes and inflammatory indicators...
BackgroundMyocardial ischaemia/reperfusion (MI/R) may induce renal damage. Our aim was to investigate the effects of dexmedetomidine (DEX) administration at two different timings either before or after ischaemia on damage induced by MI/R.MethodsMI/R injury in a rat model. we ligated left anterior descending coronary artery for 30min (ischaemic period), then reperfusion occurred 2h (reperfusion period). A single dose DEX (100µg/kg) given intraperitoneally, myocardial 5min reperfusion. With...
Abstract Introduction Proper pathophysiologic diagnosis of constrictive pericarditis (CP) usually mandates utilization multiple diagnostic tools. We report a rare cause in 33-year-old female presenting with painful epigastric pulsations, easy fatigability, and lower limb edema 6 months duration. The patient had no past history trauma, cardiac surgery, or tuberculosis. Trans-thoracic echocardiography (figure 1, panels A, parasternal long-axis view, B, apical 4-chamber view) showed an...
Abstract Introduction Assessment of mitral regurgitation (MR) mechanism is not always easy and may require advanced imaging techniques. A 28-year-old male presented with significant MR three years following surgical valve repair for severe due to prolapse. During surgery, he underwent artificial chordal implantation on A2 scallop Gore-Tex posterior band annuloplasty. Early post-operative transthoracic echocardiography (TTE) showed mild moderate eccentric, posteriorly directed unknown...
AIM: The aim of the study was to effect recombinant human bone morphogenetic protein-7 (rhBMP-7) on osteoblast-like cells cultured implant.
 MATERIALS AND METHODS: osteo-1 cell line used in this experiment and derived from parietal tissue newborn albino rats. were incubated a humid atmosphere 95% air 5% carbon dioxide at 37°C. medium changed every 2 days. Four groups conducted as follows osteoclast-like (machined), implanted titanium (Ti) (modified), supplemented with BMP-7 (Machined +...
Aim: Was to study the effect of recombinant human bone morphogenetic protein-7 (rhBMP-7) on osteoblast-like cells cultured implant titanium discs.Methodology: The Osteo-1 cell line was used in this experiment and derived from parietal tissue newborn albino rats.The incubated a humid atmosphere 95% air 5% carbon dioxide at 37°C.The medium changed every 2 days.Four groups were conducted as follow Osteoclast like (Machined), Implanted Titanium (Modified), supplemented with BMP-7 (Machined+...