A5071882751- Ion channel regulation and function
- Respiratory Support and Mechanisms
- Ion Transport and Channel Regulation
- Drug Transport and Resistance Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Biliary and Gastrointestinal Fistulas
- Pelvic floor disorders treatments
- Hip and Femur Fractures
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Colorectal Cancer Surgical Treatments
- Healthcare Systems and Practices
- Airway Management and Intubation Techniques
- Palliative Care and End-of-Life Issues
- Clinical practice guidelines implementation
- Occupational and environmental lung diseases
- Anorectal Disease Treatments and Outcomes
- Nosocomial Infections in ICU
- Hemodynamic Monitoring and Therapy
- Neuropeptides and Animal Physiology
- Gastrointestinal motility and disorders
- Neuroscience and Neuropharmacology Research
- Abdominal Trauma and Injuries
- Pancreatic function and diabetes
- Esophageal and GI Pathology
- Erythrocyte Function and Pathophysiology
Norfolk and Norwich University Hospital
2007-2025
The Dialogue
2016
Ipswich Hospital
2010
University of East Anglia
2007
Lynn University
2007
The University of Sydney
1986-1987
The capacity of the intestine to secrete fluid is dependent on basolateral Na + –K –2Cl − co‐transporter (NKCC1). Given that cAMP and Ca 2 signals promote sustained transient episodes secretion, respectively, this study investigated differential regulation functional NKCC1 membrane expression in native human colonic epithelium. Tissue sections crypts were obtained from sigmoid rectal biopsy tissue samples. Cellular location NKCC1, ‐ATPase, M3 muscarinic acetylcholine receptor (M 3 AChR)...
Abstract Traditional models of acute care have been changing to meet targets ambulance offload and ED decompression. This has led a step change in the number patients sent surgical SDEC without an increase pathology. The most precious resource on is availability Senior Decision Maker not sufficient aspiration that every patient early SDM input. Patients pathology are often harder manage for less experienced staff can endure over investigation unnecessary admission input SDM's. As corollary,...
Gallstone ileus is an uncommon cause of intestinal obstruction and occurs following the formation a cholecystoenteric fistula, permitting passage gallstones into gastrointestinal tract. Impaction gallstone in sigmoid colon rare usually at sites previous colonic disease. Definitive management can be challenging due to advanced age co-morbidity seen this group patients. We describe patient successfully managed with on-table endoscopy and, under local anaesthetic, left iliac fossa trephine loop...
The effects of substituting gluconate for extracellular Cl, and treatment with various ion transport blockers, on cytosol pH (pHi) secretion by the acetylcholine stimulated rat mandibular gland were studied in vitro. Gluconate replacement increased pHi from 7.12 +/- 0.02 to 7.27 0.04, caused secretory rate fall 75%, salivary HCO3 14 0.9 mmol/L 67 1.5 mmol/L. Furosemide (1 mmol/L), which blocks Na-K-2Cl symports Cl-HCO3 antiports, had similar those replacement, except that was reduced only...
The objective of the study is to demonstrate two methods measuring tracheal wall pressure (in vitro and in patients), with LoTrach (LVLP) cuff conventional high-volume low-pressure (HVLP) cuffs. (VTSL, Singapore) a new tube designed for use mechanical ventilation critically ill. has been shown prevent ubiquitous problem micro-aspiration secretions associated HVLP cuffs [1]. Aspiration prevention achieved by properties LoTrach's low-volume cuff, these have previously described [1,2]. It...
Luke Evans is a staff surgeon of General Surgery at Norfolk & Norwich University Hospital, Norwich, UK. Kate Manley research registrar Liz Rooney sister Surgical and Urology Outpatients The authors have disclosed that they no financial relationships related to this article. Short Communications enables clinicians trade practice tips, experiences, information, findings. Communication articles are peer reviewed, however, the goal allow free dialogue among journal readers.
Peritoneal mesothelioma is a rare intra-abdominal malignancy. Its aetiology has been thought to be due either inhalation or ingestion of asbestos particles. We present case peritoneal developing as result novel third route and the inoculation fibres into cavity by penetrating trauma direct transport. This report highlights important long term consequences abdominal need for vigilance in undertaking toilet.