A5101918951- Enzyme Catalysis and Immobilization
- Cell death mechanisms and regulation
- Ionic liquids properties and applications
- Analytical Chemistry and Chromatography
- Electrochemical sensors and biosensors
- Cancer-related Molecular Pathways
- Biochemical Analysis and Sensing Techniques
- Virus-based gene therapy research
- Protein Kinase Regulation and GTPase Signaling
- Microbial Metabolic Engineering and Bioproduction
- Trace Elements in Health
- Neuroscience of respiration and sleep
- Regulation of Appetite and Obesity
- Chemical and Physical Properties in Aqueous Solutions
- Cancer, Lipids, and Metabolism
- Ion Transport and Channel Regulation
- Pharmaceutical and Antibiotic Environmental Impacts
- Ion channel regulation and function
- Animal Genetics and Reproduction
- Biodiesel Production and Applications
- Analytical chemistry methods development
- CRISPR and Genetic Engineering
- Supercapacitor Materials and Fabrication
- Cholesterol and Lipid Metabolism
- Lubricants and Their Additives
Universidade de Vigo
2020-2023
Experimental Medicine and Biology Institute
2013-2015
Consejo Nacional de Investigaciones Científicas y Técnicas
2013-2015
Arizona State University
2014
Fundación Ciencias Exactas y Naturales
2008
University of Buenos Aires
2008
Instituto de Investigaciones Biomédicas Sols-Morreale
2002
Significance Food intake and body weight regulation depend on a group of hypothalamic neurons that release satiety-induced neuropeptides known as melanocortins. Central melanocortins are encoded by the proopiomelanocortin gene ( Pomc ), mice humans carrying deleterious mutations in display hyperphagia severe obesity. Although importance these is well understood, genetic program establishes melanocortin maintains normal expression levels remains unknown. Here, we combined molecular...
Acid-sensing ion channels (ASIC) open in response to extracellular acidosis. ASIC1a, a particular subtype of these channels, has been described have postsynaptic distribution the brain, being involved not only ischemia and epilepsy, but also fear psychiatric pathologies. High-frequency stimulation skeletal motor nerve terminals (MNTs) can induce presynaptic pH changes combination with an acidification synaptic cleft, known contribute muscle fatigue. Here, we studied role ASIC1a on...
In this work, biocompatible ionic liquids based on aminoacids were employed as extractants to separate extremolipases from aqueous streams. First, the influence of aminoacid and dipeptide-based (cholinium glycinate, ChGly, cholinium glycylglycinate, ChGlygly) lipolytic activity a commercial lipase Candida antarctica (CaLB) in-house synthesized extremophilic lipases Thermus thermophilus HB27 (TtHB27L) Halomonas sp. LM1C (HL) was investigated. The combination thermophilic enzyme with ChGly...
The ongoing energy crisis has spurred increased research into sustainable and more competitive methods for producing biofuels, including biodiesel. In this context, the focus of current study is to underscore viability investing in a novel biocatalytic complex. This complex incorporates extremophilic lipases biocompatible ionic liquids with aim achieving exceptionally high conversions transesterification reactions without generating glycerol. Through meticulous screening process encompassing...
In the present work, ability of different sodium-based salts like Na2CO3, Na2HPO4, Na2SO4 and Na2SO3 to salt out aqueous solutions two biodegradable non-ionic surfactants (Tergitol 15S7 Tergitol 15S9) has been demonstrated. We have empirically characterized immiscibility regions models Merchuk Othmer-Tobias equations were employed for binodal tie-line data, respectively. The effect phase forming components on lipolytic activity in-house extremolipases (from Thermus thermophilus HB27...