A5101818464- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Plant-Microbe Interactions and Immunity
- Acute Lymphoblastic Leukemia research
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Genomics and Phylogenetic Studies
- Blood Coagulation and Thrombosis Mechanisms
- Probiotics and Fermented Foods
- Platelet Disorders and Treatments
- High Altitude and Hypoxia
- Hematopoietic Stem Cell Transplantation
- Cell Adhesion Molecules Research
- Hemoglobinopathies and Related Disorders
- Click Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Legume Nitrogen Fixing Symbiosis
- CAR-T cell therapy research
- Soft tissue tumor case studies
- Sarcoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- Cardiovascular and exercise physiology
- Gastrointestinal motility and disorders
Pudong New Area People's Hospital
2025
Beijing Drainage Group (China)
2025
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2024
Hunan University of Traditional Chinese Medicine
2018-2024
Chongqing Medical University
2020-2022
Kunming University of Science and Technology
2021
China Institute of Sport Science
2021
Southwest Hospital
2020
Southern Medical University
2015
Nanfang Hospital
2014-2015
Protease-activated receptors 1–3 (PAR1, PAR2, and PAR3) are members of a unique G protein-coupled receptor family. They characterized by tethered peptide ligand at the extracellular amino terminus that is generated minor proteolysis. A partial cDNA sequence fourth member this family (PAR4) was identified in an expressed tag database, full-length clone has been isolated from lymphoma Daudi cell library. The ORF codes for seven transmembrane domain protein 385 acids with 33% acid identity...
Cancer development is often associated with the lack of specific and efficient recognition tumor cells by immune system. Natural killer (NK) are lymphocytes innate system that participate in elimination tumors. We report identification a cell surface molecule binds NKp30, human receptor which triggers antitumor NK cytotoxicity cytokine secretion. This previously unannotated gene belongs to B7 family and, hence, was designated B7-H6. B7-H6 NKp30-mediated activation cells. not detected normal...
The low barometric pressure at high altitude causes lower arterial oxygen content among Tibetan highlanders, who maintain normal levels of use as indicated by basal and maximal consumption that are consistent with sea level predictions. This study tested the hypothesis Tibetans resident 4,200 m offset physiological hypoxia achieve delivery means higher blood flow enabled bioactive forms NO, main endothelial factor regulating vascular resistance. natural experimental design compared U.S....
Members of the CD28 family play important roles in regulating T-cell functions and share a common gene structure profile. We have identified VSTM3 as protein whose matches that other members. This (also known TIGIT WUCAM) has been previously shown to affect immune responses is expressed on NK cells, activated memory T Tregs. The nectin-family proteins CD155 CD112 serve counter-structures for VSTM3, also bind activating receptor CD226 cells cells. Hence, this group interacting forms network...
Cytokines that signal through Class II receptors form a distinct family includes the interferons and interleukin 10 (IL-10). Recent identification of several IL-10 homologs has defined cytokine subfamily AK155, IL-19, IL-20, IL-22, IL-24. Within this subfamily, IL-24 exhibit substantial sharing receptor complexes; all three are capable signaling IL-20RA/IL-20RB, IL-20 both can also use IL-22R/IL-20RB. However, biological effects these cytokines appear quite distinct: immune activity with...
IL-22 is an IL-10 homologue that binds to and signals through the class II cytokine receptor heterodimer IL-22RA1/CRF2-4. produced by T cells induces production of acute-phase reactants in vitro vivo, suggesting its involvement inflammation. Here we report identification a designated IL-22RA2 (IL-22 receptor-alpha 2) appears be naturally expressed soluble receptor. shares amino acid sequence homology with IL-22RA1 (also known as IL-22R, zcytor11, CRF2-9) physically adjacent IL-20Ralpha...
The activation of human platelets by thrombin is mediated primarily protease-activated receptors (PARs). PAR1 and PAR4 are present on activated the hexapeptides SFLLRN GYPGQV, respectively. To further characterize involvement in platelet activation, ability or GYPGQV to generate annexin V binding newly exposed phospholipids surface procoagulant activity has been examined. Exposure phosphatidylserine phosphatidylethanolamine platelets, as determined an increase binding, was strongly...
Triggering receptor expressed on myeloid cells (TREM)-1 is an orphan implicated in innate immune activation. Inhibition of TREM-1 reduces sepsis mouse models, suggesting a role for it responses triggered by bacteria. However, the absence identified ligand has hampered full understanding function. We complexes between peptidoglycan recognition protein 1 (PGLYRP1) and bacterially derived that constitute potent capable binding inducing known functions. Interestingly, multimerization PGLYRP1...
Members of the genus Bacillus are important plant growth-promoting rhizobacteria that serve as biocontrol agents. paralicheniformis MDJK30 is a PGPR isolated from peony rhizosphere and can suppress plant-pathogenic bacteria fungi. To further uncover genetic mechanism traits its closely related strains, we used comparative genomics to provide insights into diversity evolutionary relationship between B. licheniformis.A analysis based on 55 other previously reported strains was performed. The...
Objective: To explore the relationship between sleep quality and risk of all-cause mortality based on a large-scale prospective cohort elderly people aged 60 above in Shanghai community. Methods: In 2019, 17 948 community were recruited to participate Community Elderly Cohort. Baseline information members was collected through face-to-face questionnaires, during most recent month using Pittsburgh Sleep Quality Index (PSQI) scale. The association analyzed multifactorial Cox regression models....
Abstract Background: Dual PD-1 and CTLA-4 targeting immunotherapy shows enhanced therapeutic efficacy is approved across multiple advanced solid tumor indications. In recent clinical trials, combined treatment of anti-PD-(L)1 with anti-VEGF have also been shown to improve outcomes overcome resistance either drugs alone. Bispecific antibodies PD-(L)1/CTLA-4 PD-(L)1/VEGF synergistically potentiates antitumor activity in preclinical models, more recently, demonstrated tolerability. We developed...
Abstract T cell engagers (TCEs) have recent approvals and great potential in the treatment of various diseases such as cancer auto-immune diseases. The challenge TCE solid tumor is therapeutic window due to limited specific targets, CD3 arm requires fine tuning for targets indications. anti-CD3 used current TCEs are monoclonal based diversity epitope potency, which narrows full TCEs. VHHs being single domain, ideal bi- multi-specific molecule design engineering. We identified with diverse...
Bacillus paralicheniformis MDJK30 was isolated from the rhizosphere of a peony. It could control pathogen peony root rot. Here, we report complete genome sequence B. MDJK30. Eleven secondary metabolism gene clusters were predicted.
Cardiorespiratory fitness (CRF) is the core element of health-related physical evaluation. High pressure and low oxygen in Tibet (over 3,500 m above sea level) may negatively impact residents' CRF. The 20-m shuttle run test (20mSRT) most popular field-based assessment estimate CRF children adolescents worldwide. However, normative data for residing China's plateau region are unavailable, which prevents comparability among those living at high-altitudes around world.To measure Chinese aged...