A5084014715- Neonatal and fetal brain pathology
- EEG and Brain-Computer Interfaces
- Neonatal Respiratory Health Research
- Epilepsy research and treatment
- Non-Invasive Vital Sign Monitoring
- Neuroscience of respiration and sleep
- Blind Source Separation Techniques
- Infant Development and Preterm Care
- Cardiac Arrest and Resuscitation
- ECG Monitoring and Analysis
- Heart Rate Variability and Autonomic Control
- Traumatic Brain Injury and Neurovascular Disturbances
- Congenital Heart Disease Studies
- Metabolism and Genetic Disorders
- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Optical Imaging and Spectroscopy Techniques
- Anesthesia and Neurotoxicity Research
- Fetal and Pediatric Neurological Disorders
- Infant Health and Development
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Phonocardiography and Auscultation Techniques
- Healthcare Technology and Patient Monitoring
- Metabolomics and Mass Spectrometry Studies
Infant
2016-2025
University College Cork
2016-2025
Cork University Hospital
2014-2024
Semmelweis University
2024
Universitair Ziekenhuis Leuven
2022
KU Leuven
2022
Centre Hospitalier Universitaire Sainte-Justine
2022
Université de Montréal
2022
Science Foundation Ireland
2021
Committee on Publication Ethics
2021
Abstract The emerging concept of psychobiotics—live microorganisms with a potential mental health benefit—represents novel approach for the management stress-related conditions. majority studies have focused on animal models. Recent preclinical identified B. longum 1714 strain as putative psychobiotic an impact behaviors, physiology and cognitive performance. Whether such effects could be translated to healthy human volunteers remains unknown. We tested whether consumption affect stress...
Neonatal seizures are often subclinical, making accurate diagnosis difficult.To describe the clinical manifestations of electrographic recorded on continuous video-EEG, and to compare this description with recognition by experienced neonatal staff.Term infants, at risk seizures, were monitored 12-channel video-EEG from <6 hours birth for up 72 hours. All staff individual seizure charts. Video-EEG recordings subsequently analysed. The number, duration expression calculated (in seconds),...
The study presents a multi-channel patient-independent neonatal seizure detection system based on the Support Vector Machine (SVM) classifier.A machine learning algorithm is used as classifier to discriminate between and non-seizure EEG epochs. Two post-processing steps are proposed increase both temporal precision robustness of system. resulting validated large clinical dataset 267 h data from 17 full-term newborns with seizures.The performance using event-based metrics reported. showed...
We examined the evolution of electroencephalographic (EEG) changes after hypoxic injury.Continuous, multichannel, video-EEG was recorded for term infants with hypoxic-ischemic encephalopathy, from <6 hours to 72 delivery. One-hour segments at 6, 12, 24, and 48 age EEG were analyzed visually, neurologic outcome assessed 24 months.Forty-four completed neurodevelopmental follow-up. Of those, 20 (45%) had abnormal outcomes. The grade assigned correlated significantly outcome. abnormalities...
Background: Footnote Research training is essential in a modern undergraduate medical curriculum. Our evaluation aimed to (a) gauge students’ awareness of research activities, (b) compare perceptions their transferable and research-specific skills competencies, (c) determine motivation for (d) obtain personal views on doing research. Methods: Undergraduate students (N=317) completed questionnaire developed by the Centre Excellence Teaching Learning Applied Skills (CETL-AURS) at Reading...
Aim To examine the relationship between electrographic seizures and long‐term outcome in neonates with hypoxic–ischemic encephalopathy ( HIE ). Method Full‐term born Cork University Maternity Hospital from 2003 to 2006 (pre‐hypothermia era) 2009 2012 (hypothermia were included this observational study. All had early continuous electroencephalography monitoring. annotated. The total seizure burden hourly calculated. Outcome (normal/abnormal) was assessed at 24 48 months surviving using either...
Therapeutic hypothermia reduces risk of death and disability in infants with moderate to severe hypoxic ischemic encephalopathy (HIE). Randomized clinical trials therapeutic date have not included mild HIE because a perceived good prognosis.To test the hypothesis that children worse neurodevelopmental outcomes than their healthy peers.Analysis pooled data from 4 prospective cohort studies Cork, Ireland, Stockholm, Sweden, between January 2007 August 2015. The dates analysis were September...
To evaluate the effectiveness of phenobarbitone as an anticonvulsant in neonates.An observational study using video-EEG telemetry. Video-EEG was obtained before treatment started, for hour after given, two hours and again between 12 24 given. Patients were recruited from all babies who required (20-40 mg/kg intravenously over 20 minutes) suspected clinical seizures had EEG monitoring one up to initial dose. An seizure discharge defined a sudden repetitive stereotyped lasting at least 10...
Accurate diagnosis of neonatal seizures is critically important and often made clinically, without EEG (electroencephalography) monitoring. This observational study aimed to determine the accuracy interobserver reliability healthcare professionals in distinguishing clinically manifested from other movements, when presented with clinical histories digital video recordings only.Twenty paroxysmal movements term preterm infants were selected a video-EEG database. The categorized as seizure...
More than half of all infants with neonatal hypoxic ischemic encephalopathy (HIE) are graded as mild and do not meet current criteria for therapeutic hypothermia. These often enrolled in follow-up, hence our knowledge their long-term outcome is sparse. We wished to compare 5-year outcomes a group mild, moderate, severe HIE, both early EEG clinical assessment, none whom were treated hypothermia.Term HIE healthy comparison recruited at birth. Both groups had continuous recordings. Cognitive...
<h3>Objective</h3> To investigate any possible effect of cooling on seizure burden, the authors quantified recorded electrographic burden based multichannel video-EEG recordings in term neonates with hypoxic-ischaemic encephalopathy (HIE) who received and those did not. <h3>Study design</h3> Retrospective observational study. <h3>Patients</h3> Neonates >37 weeks gestation born between 2003 2010 two hospitals. <h3>Methods</h3> Off-line analysis prolonged continuous was performed...
Despite the availability of continuous conventional electroencephalography (cEEG), accurate diagnosis neonatal seizures is challenging in clinical practice. Algorithms for decision support recognition could improve detection. We aimed to assess diagnostic accuracy an automated seizure detection algorithm called Algorithm Neonatal Seizure Recognition (ANSeR).
Summary Purpose: Hypoxic ischemic encephalopathy (HIE) accounts for 60% of all neonatal seizures. There is emerging evidence that seizures cause additional injury to the developing brain has sustained hypoxic injury. Temporal evolution clinical seizure burden in HIE been characterized, with maximum (the period activity) being observed between 12 and 24 h age. The purpose our study was investigate distribution electrographic accumulated duration over a defined time period), following initial...
ObjectiveTo assess the impact of time to treatment first electrographic seizure on subsequent burden and describe overall management in a large neonatal cohort.Study designNewborns (36-44 weeks gestation) requiring electroencephalographic (EEG) monitoring recruited 2 multicenter European studies were included. Infants who received antiseizure medication exclusively after onset grouped based seizure: within 1 hour, between hours, hours. Outcomes measured burden, maximum status epilepticus,...
To determine whether restricting the use of inotrope after diagnosis low blood pressure (BP) in first 72 hours life affects survival without significant brain injury at 36 weeks postmenstrual age (PMA) infants born before 28 gestation.Double-blind, placebo-controlled randomised trial. Caregivers were masked to group assignment.10 sites across Europe and Canada.Infants gestation eligible if they had an invasive mean BP less than their gestational that persisted for ≥15 min a cerebral...