A5073667857- Influenza Virus Research Studies
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Reproductive tract infections research
- Urban and Rural Development Challenges
- Viral gastroenteritis research and epidemiology
- Housing, Finance, and Neoliberalism
- Glycosylation and Glycoproteins Research
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Urban Planning and Governance
- Coccidia and coccidiosis research
- Bacterial Genetics and Biotechnology
- Escherichia coli research studies
- Vibrio bacteria research studies
- Virology and Viral Diseases
- Migration, Aging, and Tourism Studies
- Cultural Heritage Management and Preservation
- Viral Infections and Vectors
- Salmonella and Campylobacter epidemiology
- interferon and immune responses
- Bacteriophages and microbial interactions
- Advanced Statistical Methods and Models
- Neonatal Respiratory Health Research
- Bacillus and Francisella bacterial research
Heriot-Watt University
2011-2024
Morriston Hospital
2023
Barts Health NHS Trust
2023
St Bartholomew's Hospital
2023
Aintree University Hospitals NHS Foundation Trust
2023
University of Liverpool
2023
University of Toronto
1984-2022
University of Technology Sydney
2022
The University of Sydney
2022
University of British Columbia
2022
Seventy-one "negative" randomized control trials were re-examined to determine if the investigators had studied large enough samples give a high probability (greater than 0.90) of detecting 25 per cent and 50 therapeutic improvement in response. Sixty-seven greater 10 risk missing true improvement, with same risk, could have missed improvement. Estimates 90 confidence intervals for each trial showed that 57 these trials, potential was possible, 34 Many therapies labeled as "no different from...
The CC chemokine eotaxin, identified in guinea pigs and also recently mice, may be a key element for the selective recruitment of eosinophils to certain inflamed tissues. Using partial mouse eotaxin CDNA probe, human gene was cloned found 61.8 63.2% identical at amino acid level pig eotaxin. Human protein strong specific eosinophil chemoattractant vitro an effective when injected into skin rhesus monkey. Radiolabeled used identify high affinity receptor on (0.52 nM Kd), expressed 4.8 x 10(4)...
In gram-negative bacterial pathogens, such as Pseudomonas aeruginosa and Yersinia pseudotuberculosis, cell-to-cell communication via the N-acylhomoserine lactone (AHL) signal molecules is involved in cell population density-dependent control of genes associated with virulence. This phenomenon, termed quorum sensing, relies upon accumulation AHLs to a threshold concentration at which target structural are activated. By using biosensors capable detecting range we observed that, cultures Y....
After growth of gonococci in the presence cytidine monophospho-N-acetyl-neuraminic acid (CMP-NANA), their 4.5-kD lipooligosaccharide (LOS) component was increased by approximately 400 daltons, whereas LOS strains lacking were unaffected. Expression mAb-defined epitopes on decreased grown CMP-NANA, and treatment with neuraminidase reversed this affect. Gonococci incubated human PMNs also had expression 4.5-kD+ epitopes. A detergent extract incorporated radiolabeled NANA LOS, suggesting a...
A low-M r factor which induces gonoccocal resistance to complement-mediated serum killing has been partially purified from lysates of mixed red and buffy coat cells human blood. The were dialysed against Tris buffer for 24 h at 25 °C with the diffusate being continuously recycled through a column QAE-Sephadex A25. After elution in an NaCl gradient, active fractions both desalted further on Sephadex G10. second fractionation A25 desalting G10 preceded purification by repeated high-pressure...
The virulent influenza virus clone 7a produced a greater level of apoptosis in MDCK cells compared with the attenuated strain A/Fiji. In both cases, could be partially blocked by treatment three anti-neuraminidase compounds [4-amino-(GR121158A) and 4-guanidino-(GG167; Zanamivir) 2,3-dehydro-N-acetylneuraminic acid 2,3-dehydro-2-deoxy-N-acetylneuraminic (DANA)] when they were given to during attachment/entry phase, but not subsequent this phase. contrast, GG167, which does enter cells, did...
The effect of suppression fever on viral levels in nasal washes ferrets infected with either two clones (7a, virulent; 64d, attenuated) the recombinant influenza virus A/Puerto Rico/8/34#x2013;A/England/939/69 (H3N2) was studied. febrile response reduced by shaving or treating them sodium salicylate, which had no noticeable inflammatory response. For both clones, significantly more shed whose suppressed, and decreased less rapidly than untreated those treatments were ineffective.