A5081727258- Synthesis and biological activity
- Click Chemistry and Applications
- Genetics, Bioinformatics, and Biomedical Research
- Medicinal Plants and Neuroprotection
- Analytical Chemistry and Chromatography
- Computational Drug Discovery Methods
- Enzyme function and inhibition
- Chemical Reactions and Mechanisms
- Pharmacological Effects and Assays
- Biochemical Analysis and Sensing Techniques
- Analytical Methods in Pharmaceuticals
- Plant biochemistry and biosynthesis
- Synthesis and Biological Evaluation
- Advanced Chemical Sensor Technologies
JSS Academy of Higher Education and Research
2016-2018
A series of 1,3,4-oxadiazoles were designed and subjected to molecular docking simulation onto the enzymes vitamin K epoxide reductase (PDB: <bold>3KP9</bold>) factor Xa <bold>1NFY</bold>) visualize their binding affinity towards said target proteins.
Introduction: The aim of study was to develop a simple, sensitive and precise gas chromatographic method for the analysis β-asaronein ethanolic, ethyl acetate, aqueous extracts from rhizomes Acorus calamus validate according current ICH guidelines. Followed by evaluation antimicrobial activity prepared in comparison with penicillin disc. Methods: β-asarone one chief active constituent calamus. extract further evaluated its against Streptococcus Mutants agar well diffusion method. GC used...
Objective: The present study aims at the development of a reversed phase ultra-fast liquid chromatography (RP-UFLC) method for measurement lipophilicity (log P) between n-octanol and water newly synthesized coumarin derivatives in our laboratory.Methods: compounds were dissolved methanol analyzed using XTerra RP18 column as stationary mixture (0.25% v/v octanol) buffer mobile with isocratic elution.Results: In this we concentrated on relationship reversed-phase retention parameters log P...
Objective: The importance of this research work is to design a library novel coumarin derivatives by docking evaluation the designed as squalene synthase inhibitor.Methods: three-dimensional structure molecules inhibitors was collected from Protein Data Bank. were docked onto enzymes that are inhibitor - 3WCM, 3WCJ, and 3Q2Z protein using SYBYL-X 2.1. Using standard protocol, subjected minimization protomol generation.Results: By method, we visualized possible binding also estimated...