Gokul Kalyanasundaram

ORCID: 0000-0003-0933-8537
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About
Contact & Profiles
Research Areas
  • Diversity and Career in Medicine
  • Hepatitis C virus research
  • Bone fractures and treatments
  • Medical Education and Admissions
  • Neurotransmitter Receptor Influence on Behavior
  • HIV/AIDS drug development and treatment
  • Viral Infections and Immunology Research
  • Neuroscience and Neuropharmacology Research
  • Anesthesia and Sedative Agents
  • Memory and Neural Mechanisms
  • Intensive Care Unit Cognitive Disorders
  • Dental Education, Practice, Research
  • Orthopaedic implants and arthroplasty
  • Gene expression and cancer classification
  • Immune cells in cancer
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Global Health Workforce Issues
  • Neuropeptides and Animal Physiology
  • Pelvic and Acetabular Injuries
  • Cell Image Analysis Techniques
  • Management of metastatic bone disease
  • Reconstructive Surgery and Microvascular Techniques
  • Single-cell and spatial transcriptomics
  • Orthopedic Surgery and Rehabilitation
  • Stress Responses and Cortisol

Albany Medical Center Hospital
2020-2025

University of Pennsylvania
2024

University of California, San Francisco
2022

Rensselaer Polytechnic Institute
2020

Sengkang General Hospital
2019

Microgliosis is a hallmark of many neurological diseases, including Alzheimer's disease, stroke, seizure, traumatic brain and spinal cord injuries, peripheral optic nerve injuries. Recent studies have shown that the newly self-renewed microglia specific functions. However, mechanism adult proliferation remains largely unclear. Here, with single-cell RNA sequencing, flow cytometry, immunohistochemistry, we demonstrate sciatic injury induced two distinct phases in mouse cord, each different...

10.1038/s41421-022-00377-3 article EN cc-by Cell Discovery 2022-04-12

Orthopaedic surgery has recruited fewer applicants from underrepresented in medicine (UIM) racial groups than many other specialties, and recent studies have shown that although UIM are competitive for orthopaedic surgery, they enter the specialty at lower rates. Although previous measured trends applicant, resident, or attending diversity isolation, these populations interdependent therefore should be analyzed together. It is unclear how among applicants, residents, faculty changed over...

10.1097/corr.0000000000002700 article EN Clinical Orthopaedics and Related Research 2023-05-23

Introduction A study was conducted to describe the sedation practices of intensive care units (ICUs) in Singapore terms drug use, depth and incidence delirium both early ( 48 hours) periods ICU admission. Methods prospective multicentre cohort on patients who were expected be sedated ventilated for over 24 hours seven ICUs (surgical ICU, n = 4; medical 3) four major public hospitals Singapore. Patients followed up 28 days or until discharge, with four-hourly monitoring daily assessment by...

10.11622/smedj.2019055 article EN Singapore Medical Journal 2019-06-14

The use of immunohistochemistry to quantify neural markers in various brain regions is a staple neuroscience research. Numerous programs exist automate quantification, but manual assignment interest (ROIs) within individual sections remains time consuming and can introduce interobserver variability. We have developed novel open source FIJI-based immunohistochemical data analysis pipeline, Atlas-Based Analysis (ABA). ABA uses landmark-based image warping adjust the experimental closely align...

10.1016/j.jneumeth.2020.108982 article EN cc-by-nc-nd Journal of Neuroscience Methods 2020-10-20

Abstract Data in both humans and preclinical animal models clearly indicate drug exposure during adolescence, when the “reward” circuitry of brain develops, increases risk substance use other mental health disorders later life. Human data that different neural behavioral sequelae can be observed early versus late adolescence. However, most studies with rodent examine a single adolescent age compared to mature adult age, often only males. Herein, we sought determine whether acute response...

10.1002/dev.22186 article EN cc-by Developmental Psychobiology 2021-08-22

Background: The coronavirus disease 2019 (COVID-19) pandemic has disrupted the American economy and healthcare system. aim of our observational retrospective cohort study was to evaluate short-term effect orthopaedic surgical volume at a large tertiary care center. We hypothesized slow resurgence in

10.21037/jhmhp-23-16 article EN cc-by-nc-nd Journal of Hospital Management and Health Policy 2023-06-01

This information may help guide education and recruitment efforts of fellowship directors societies. It also orthopaedic surgical residents considering oncology. The purpose this study was to characterize the demographics, education, professional activities, location practice all academic oncologists in United States. Academic affiliated with residency programs fifty states, Washington D. C., Puerto Rico were included. Demographics, data obtained from program faculty websites Doximity...

10.1016/j.jorep.2024.100436 article EN cc-by-nc-nd Journal of Orthopaedic Reports 2024-06-18

Orthopaedic surgery has struggled with low female representation, spurring new initiatives to recruit diverse applicants the field. We aimed characterize trends in gender diversity among orthopaedic applicants, residents, physician assistants, and faculty compare these all other surgical medical specialties. Data on of every specialty from 2016-2020 were obtained. Female representation increased between 2016 2020 14.7% 19.7%, residents 14.8% 16.0%, assistants 50.1% 52.3%, 18.2% 20.5%....

10.2106/jbjs.jopa.24.00017 article EN JBJS Journal of Orthopaedics for Physician Assistants 2024-07-01

Abstract Drug and alcohol use during adolescence is common, data in both humans preclinical animal models clearly indicate drug exposure increases the risk of substance other mental health disorders later life. Adolescence a period social, emotional, cognitive development, characterized by increased exploratory behavior, risk-taking, peer-centered social interactions. These are thought to be behavioral manifestations developmental plasticity ‘reward’ regions brain. Human that not unitary...

10.1101/2021.04.29.441958 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2021-04-30
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