A5041008078- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Advancements in Battery Materials
- Biochemical Acid Research Studies
- Advanced Battery Materials and Technologies
- Diet and metabolism studies
- Cancer-related gene regulation
- Cholesterol and Lipid Metabolism
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- Advanced battery technologies research
- Conducting polymers and applications
- Metabolism and Genetic Disorders
- Circular RNAs in diseases
- PI3K/AKT/mTOR signaling in cancer
- Metabolism, Diabetes, and Cancer
- Immune cells in cancer
- Amino Acid Enzymes and Metabolism
- Plant biochemistry and biosynthesis
- Natural Antidiabetic Agents Studies
- Advanced Glycation End Products research
- MicroRNA in disease regulation
Wuhan University
2022-2025
Xuzhou Medical College
2019-2024
Toxicologie, Pharmacologie et Signalisation Cellulaire
2023
Cell Signaling Technology (United States)
2023
Cancer Institute (WIA)
2020
Shanghai Jiao Tong University
2013-2019
Jiangsu University
2018
Xuzhou Cancer Hospital
2018
Abstract Background Increasing studies have shown that long noncoding RNAs (lncRNAs) are pivotal regulators participating in carcinogenic progression and tumor metastasis colorectal cancer (CRC). Although lncRNA intergenic RNA 460 (LINC00460) has been reported CRC, the role molecular mechanism of LINC00460 CRC still requires exploration. Methods The expression levels were analyzed by using a tissue microarray containing 498 tissues their corresponding non-tumor adjacent tissues. correlations...
Abstract Polyaniline is the most famous conducting polymer and also a promising organic cathode material for rechargeable batteries, however, it has demonstrated poor utilization of its theoretical capacity (294 mAh g −1 ) inferior cycling stability in previous studies. Herein, first time, fully reduced form, i.e., leucoemeraldine base (LB), studied as an alternative to commonly used emeraldine salt (ES EB). For three different forms, precise structures are carefully determined,...
Abstract Transketolase (TKT) which is an important metabolic enzyme in the pentose phosphate pathway (PPP) participates maintaining ribose 5-phosphate levels. TKT necessary for cell growth. However, we found that addition to this, can also affect tumor progression through other ways. Our previous study indicate could promote development of liver cancer by affecting bile acid metabolism. And this study, discovered expression was remarkably upregulated colorectal cancer, abnormal high...
Protein arginine methyltransferase 1 (PRMT1) is able to promote breast cancer cell proliferation. However, the detailed mechanisms of PRMT1-mediated proliferation are largely unknown. In this study, we reveal that methylation EZH2 at R342 site (meR342-EZH2) has a great effect on PRMT1-induced We also demonstrate meR342-EZH2 can accelerate in vitro and vivo. Further, show promotes cycle progression by repressing P16 P21 transcription expression. terms mechanism, illustrate facilitates binding...
Metabolic reprogramming is a hallmark of various cancers. Targeting metabolic processes very attractive treatment for cancer. Renal cell carcinoma (RCC) type disease, and the lipidomic profile RCC significantly altered compared with that healthy tissue. However, molecular mechanism underlying lipid metabolism regulation in not clear.The XF long-chain fatty acid oxidative stress test kits were used to assess dependence on acids mitochondrial function after knockdown TRIM21 cells. The effect...
Abstract De novo nucleotide biosynthesis is essential for maintaining cellular pools, the suppression of which leads to genome instability. The metabolic enzyme transketolase (TKT) in nonoxidative branch pentose phosphate pathway (PPP) regulates ribose 5-phosphate (R5P) levels and de biosynthesis. TKT required cell proliferation human liver cancer lines, yet role injury initiation remains be elucidated. In this study, we generated a liver-specific knockout mouse strain by crossing...
Colorectal cancer (CRC) remains the fourth most common cause of cancer-related mortality worldwide. We aimed to identify key molecules and signalling pathways mediating CRC growth metastasis. Polypyrimidine tract-binding protein 3 (PTBP3) is a member PTB family. A prooncogenic role for PTBP3 has also been discovered in several kinds tumors. However, expression biological functions are still unknown CRC. analysed levels using tissue microarray containing 568 tissues corresponding non-tumor...
Abstract The metastasis of non-small cell lung cancer (NSCLC) is the leading death cause NSCLC patients, which requires new biomarkers for precise diagnosis and treatment. Circular RNAs (circRNAs), novel noncoding RNA, participate in progression various cancers as microRNA or protein sponges. We revealed mechanism by circEPB41L2 (hsa_circ_0077837) blocks aerobic glycolysis, through modulating metabolism PTBP1 E3 ubiquitin ligase TRIP12. With ribosomal RNA-depleted RNA seq, 57 upregulated 327...
Transketolase (TKT), which is a metabolic enzyme in the nonoxidative phase of pentose phosphate pathway (PPP), plays an important role providing cancer cells with raw materials for macromolecular biosynthesis. The ectopic expression TKT hepatocellular carcinoma (HCC) was reported previously. However, initiation liver still obscure. In our previous study, we found that deficiency protects from DNA damage by increasing levels ribose 5-phosphate and nucleotides. What's more interesting reduced...
Obesity has recently become a prevalent health threat worldwide. Although emerging evidence suggested strong link between the pentose phosphate pathway (PPP) and obesity, role of transketolase (TKT), an enzyme in nonoxidative branch PPP that connects glycolysis, remains obscure adipose tissues. In this study, we specifically deleted TKT mouse adipocytes found no obvious phenotype upon normal diet feeding. However, adipocyte abrogation attenuated high-fat diet–induced reduced hepatic...
Abstract Sustainable and structurally designable organic cathode materials hold immense promise for rechargeable lithium batteries, yet the dissolution issue poses a significant challenge to their cycling stability. For small‐molecule (SMOCMs), extending π‐conjugated system is an effective method mitigate dissolution, however, remains huge if requiring high energy density affordable synthesis concurrently. Herein, novel quinone‐based SMOCM successfully synthesized though straightforward...
Organic cathode materials (OCMs) have tremendous potential to construct sustainable and highly efficient batteries beyond conventional Li-ion batteries. Thereinto, quinone/pyrazine hybrids show significant advantages in material availability, energy density, cycling stability. Herein, we propose a facile method synthesize hybrids, i.e., the condensation reaction between ortho-diamine bromoacetyl groups. Based on it, successfully synthesized three 1,4-diazaanthraquinone (DAAQ) dimers,...
// Xiao-Yun Zhang 1, * , Minle Li 2, Kai Sun Xiao-Jie Chen 1 Jian Meng 2 Lifang Wu Ping Xuemei Tong Wei-Wen Jiang Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Jiao University School Medicine, 200011, China Biochemistry and Molecular Cell Biology, Key Laboratory for Tumor Microenvironment Inflammation, 200025, These authors contributed equally to this work Correspondence to: Jiang, e-mail: wwjiang33@hotmail.com Tong, xuemeitong@shsmu.edu.cn Keywords: GRIM-19,...