A5086086911- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Thermoregulation and physiological responses
- Exercise and Physiological Responses
- Hydrogen's biological and therapeutic effects
- Climate Change and Health Impacts
- Cardiovascular Function and Risk Factors
- Endoplasmic Reticulum Stress and Disease
- Heart Failure Treatment and Management
- Heat shock proteins research
- Diabetes Treatment and Management
University of Ottawa
2020-2022
Autophagy is essential to maintaining cellular homeostasis in all eukaryotic cells and tolerance of acute stressors such as starvation, heat, recovery after exercise. Limited information exists regarding the exercise intensity-dependent autophagic response humans, it unknown how environmental heat stress may modulate this response. Therefore, we evaluated autophagy accompanying pathways [the heat-shock (HSR), apoptosis, inflammation] peripheral blood mononuclear (PBMCs) from 10 young men...
When exposed to stress caused by elevated internal body temperatures, proteins become denatured or misfolded, leading toxic protein aggregation. To protect the cell under heat stress, misfolded are tagged refolded shock (HSP). Under conditions of extreme process autophagy has previously been shown human cells, but exact temperatures at which autophagic activation occurs is largely unknown. Further, interplay HSP and responses as a function increasing levels hyperthermia have yet be examined....
Recent evidence has revealed a complex interplay between circulating inflammatory cytokines (e.g. TNF-α, IL-6) and susceptibility to heat illness, particularly in older adults who demonstrate dysregulation the response. Endothelial monocyte-activating polypeptide II (EMAP-II) is pro-inflammatory cytokine involved number of immune responses. However, EMAP-II response, as it relates exercise-heat stress not known. This may be important mediating response adults, are known at higher risk for...
Heat‐stress induced dehydration is associated with elevations in extracellular osmolality. To counteract the resultant osmotic stress, cells employ several stress response systems including heat shock protein (HSP) and autophagy pathways. HSPs refold damaged proteins, whereas acts to degrade cellular components, thereby promoting survival. Accumulating evidence indicates a coordinated between HSP systems, whereby both are activated under conditions of stress. However, it remains unknown...
Autophagy is a vital cellular mechanism that maintains normal function during acute stressors, including exercise and heat stress, by degrading recycling damaged or dysfunctional constituents, thereby enabling processes to survive the stress insult. Despite implications of being potent stimulus autophagy, relationship between intensity activation autophagy remains unclear in humans. Further, while associated with exacerbated when performed heat, it unknown if this corresponding change...