A5000809648- Plant biochemistry and biosynthesis
- Bioactive Natural Diterpenoids Research
- Essential Oils and Antimicrobial Activity
- Plant and animal studies
- Sesquiterpenes and Asteraceae Studies
- Plant tissue culture and regeneration
- Ecology and Vegetation Dynamics Studies
- Genetic diversity and population structure
- Cassava research and cyanide
- Toxic Organic Pollutants Impact
- Interdisciplinary Research and Collaboration
- Allelopathy and phytotoxic interactions
- Plant-based Medicinal Research
- Sustainability and Climate Change Governance
- Plant chemical constituents analysis
- Research Data Management Practices
- Lichen and fungal ecology
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Radioactive contamination and transfer
- Genomics and Phylogenetic Studies
- Metabolomics and Mass Spectrometry Studies
Norwegian Institute of Marine Research
2021-2022
Natural History Museum Aarhus
2018-2020
University of Copenhagen
2017-2020
National Museum of Denmark
2017
Technical University of Denmark
2017
Coevolutionary theory suggests that an arms race between plants and herbivores yields increased plant specialized metabolite diversity the geographic mosaic of coevolution predicts coevolutionary interactions vary across scales. Consequently, is expected to be highest in hotspots, regions, which exhibit strong reciprocal selection on interacting species. Despite being well established theoretical frameworks, technical limitations have precluded rigorous hypothesis testing. Here we aim at...
Thapsigargin and nortrilobolide are sesquiterpene lactones found in the Mediterranean plant Thapsia garganica L. is a potent inhibitor of sarco/endoplasmic reticulum calcium ATPase pump, inducing apoptosis mammalian cells. This mechanism has been used to develop thapsigargin-based cancer drug first by GenSpera later Inspyr Therapeutics (Westlake Village, California). However, stable production thapsigargin not established.In vitro regeneration from leaf explants, shoot multiplication rooting...
The Mediterranean plant Thapsia garganica (dicot, Apiaceae), also known as deadly carrot, produces the highly toxic compound thapsigargin. This is a potent inhibitor of sarcoplasmic-endoplasmic reticulum Ca2+-ATPase calcium pump in mammals and industrial importance active moiety anticancer drug mipsagargin, currently clinical trials. Knowledge thapsigargin planta storage biosynthesis has been limited. Here, we present putative second step biosynthesis, by showing that cytochrome P450...
Although most point sources of persistent organic pollutants (POPs), including polycyclic aromatic hydrocarbons (PAHs), are at lower latitudes, the Arctic region is contaminated. In particular, PAHs now dominate POP body burden region's marine biota trophic levels. Greenlandic Inuits have elevated levels POPs in their blood compared to any other population, due consumption seal meat and mammals. PAHs, by-products incomplete combustion petroleum products, known carcinogens been shown affect...
Retracing pathways of historical species introductions is fundamental to understanding the factors involved in successful colonization and spread, centuries after a species’ establishment an introduced range. Numerous plants have been regions outside their native ranges both intentionally accidentally by European voyagers early colonists making transoceanic journeys; however, records are scarce document this. We use genotyping-by-sequencing genotype-likelihood methods on selfing, global...
The value of interdisciplinarity for solving complex coastal problems is widely recognized. Many early career researchers (ECRs) therefore actively seek this type collaboration through choice or necessity, professional development project funding. However, establishing and conducting interdisciplinary research collaborations as an ECR has many challenges. Here, we identify these challenges the lens ECRs working in different disciplines on a common ecosystem, Norwegian Skagerrak coast. most...
Abstract The genus Euphorbia is among the most diverse and species-rich plant genera on Earth, exhibiting a near-cosmopolitan distribution extraordinary chemical diversity, especially across highly toxic macro-and polycyclic diterpenoids. However, very little known about drivers evolutionary origins of diversity within . Here, we investigate 43 species to understand how geographic separation over time has impacted differentiation. We show that structurally diterpenoids are significantly...