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A5007545092
Research Areas
- Telomeres, Telomerase, and Senescence
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
The Wistar Institute
2019
Telomerase, a unique reverse transcriptase that specifically extends the ends of linear chromosomes, is up-regulated in vast majority cancer cells. Here, we show an indole nucleotide analog, 5-methylcarboxyl-indolyl-2′-deoxyriboside 5′-triphosphate (5-MeCITP), functions as inhibitor telomerase activity. The crystal structure 5-MeCITP bound to Tribolium castaneum reveals atypical interaction, which nucleobase flipped active site. In this orientation, methoxy group out canonical site interact...
10.1371/journal.pbio.3000204
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PLoS Biology
2019-04-05
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